Measurement of GABA and contaminants in gray and white matter in human brain in vivo

A preliminary study of discrimination between GABA and macromolecules (MMs) in human brain by proton double quantum filtering (DQF) at 3.0T in vivo is presented. GABA‐tuned and MM‐tuned DQ filters were designed with dual‐band 180° radiofrequency (RF) pulses that were tuned for selective refocusing o...

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Bibliographic Details
Published in:	Magnetic resonance in medicine Vol. 58; no. 1; pp. 27 - 33
Main Authors:	Choi, Changho, Bhardwaj, Paramjit P., Kalra, Sanjay, Casault, Colin A., Yasmin, Umme S., Allen, Peter S., Coupland, Nicholas J.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-07-2007
Subjects:	brain Brain Chemistry double-quantum filtering GABA gamma-Aminobutyric Acid - analysis gray and white matter Humans macromolecules Magnetic Resonance Spectroscopy - methods proton MRS
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Summary:	A preliminary study of discrimination between GABA and macromolecules (MMs) in human brain by proton double quantum filtering (DQF) at 3.0T in vivo is presented. GABA‐tuned and MM‐tuned DQ filters were designed with dual‐band 180° radiofrequency (RF) pulses that were tuned for selective refocusing of GABA (3.0 and 1.9 ppm) and putative MM resonances (3.0 and 1.7 ppm), respectively. GABA and putative MM signals were extracted from a combined analysis of the filtered mixture signals and the calculated editing yields. Unexpectedly, the GABA and putative MM signals exhibited a similar doublet linewidth at the optimized TE = 82 ms. Furthermore, substantial MM‐tuned DQF signal remained at TE = 148 ms, indicating the presence of a component other than MM. With water segmentation data, the GABA‐tuned and MM‐tuned DQF measures from the medial prefrontal and left frontal lobes were combined to give the concentrations of GABA and the additional component as 1.1 ± 0.1 and 0.8 ± 0.1 mM (mean ± SD, N = 3) for gray matter (GM) and 0.4 ± 0.1 and 0.7±0.1 mM (N = 3) for white matter (WM), respectively. Magn Reson Med 58:27–33, 2007. © 2007 Wiley‐Liss, Inc.
Bibliography:	ark:/67375/WNG-9RBGS0PN-Q ArticleID:MRM21275 Canadian Institutes for Health Research; Alberta Heritage Foundation for Medical Research istex:E12E64BF26428E1C5553D2FEC3182FCDCD983E89 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0740-3194 1522-2594
DOI:	10.1002/mrm.21275