Search Results - "Yashiroda, Hideki"

The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction by Koizumi, Shun, Irie, Taro, Hirayama, Shoshiro, Sakurai, Yasuyuki, Yashiroda, Hideki, Naguro, Isao, Ichijo, Hidenori, Hamazaki, Jun, Murata, Shigeo

“…In response to proteasome dysfunction, mammalian cells upregulate proteasome gene expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident…”
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Identification of minimum Rpn4-responsive elements in genes related to proteasome functions by Shirozu, Ryohei, Yashiroda, Hideki, Murata, Shigeo

“…•Rpn4 recognizes not only the typical nonamer PACE but a hexamer PACE-core sequence.•Many genes involved in proteasome function have PACE-cores and are induced…”
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Proteasome Impairment Induces Recovery of Mitochondrial Membrane Potential and an Alternative Pathway of Mitochondrial Fusion by Shirozu, Ryohei, Yashiroda, Hideki, Murata, Shigeo

“…Mitochondria are vital and highly dynamic organelles that continuously fuse and divide to maintain mitochondrial quality. Mitochondrial dysfunction impairs…”
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A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes by Hamazaki, Jun, Iemura, Shun-ichiro, Natsume, Tohru, Yashiroda, Hideki, Tanaka, Keiji, Murata, Shigeo

“…The 26S proteasome is a multisubunit protease responsible for regulated proteolysis in eukaryotic cells. It is composed of one catalytic 20S proteasome and two…”
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PAC1‐PAC2 proteasome assembly chaperone retains the core α4–α7 assembly intermediates in the cytoplasm by Wu, Wei, Sahara, Kazutaka, Hirayama, Shoshiro, Zhao, Xian, Watanabe, Ayaka, Hamazaki, Jun, Yashiroda, Hideki, Murata, Shigeo

“…The proteasome core particle (CP) is a cytoplasmic and nuclear protease complex and is comprised of two α‐rings and two β‐rings stacked in order of αββα. The…”
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The Molecular Mechanisms Governing the Assembly of the Immuno- and Thymoproteasomes in the Presence of Constitutive Proteasomes by Watanabe, Ayaka, Yashiroda, Hideki, Ishihara, Satoshi, Lo, Megan, Murata, Shigeo

“…The proteasome is a large protein complex responsible for proteolysis in cells. Though the proteasome is widely conserved in all eukaryotes, vertebrates…”
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The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation by Takehara, Yuka, Yashiroda, Hideki, Matsuo, Yoshitaka, Zhao, Xian, Kamigaki, Akane, Matsuzaki, Tetsuo, Kosako, Hidetaka, Inada, Toshifumi, Murata, Shigeo

“…Ubiquitination is a major post-translational modification of ribosomal proteins. The role of ubiquitination in the regulation of ribosome functions is still…”
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Sirt1-deficiency causes defective protein quality control by Tomita, Takuya, Hamazaki, Jun, Hirayama, Shoshiro, McBurney, Michael W., Yashiroda, Hideki, Murata, Shigeo

“…Protein quality control is an important mechanism to maintain cellular homeostasis. Damaged proteins have to be restored or eliminated by degradation, which is…”
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N-Terminal α7 Deletion of the Proteasome 20S Core Particle Substitutes for Yeast PI31 Function by Yashiroda, Hideki, Toda, Yousuke, Otsu, Saori, Takagi, Kenji, Mizushima, Tsunehiro, Murata, Shigeo

“…The proteasome core particle (CP) is a conserved protease complex that is formed by the stacking of two outer α-rings and two inner β-rings. The α-ring is a…”
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The mechanism for molecular assembly of the proteasome by Sahara, Kazutaka, Kogleck, Larissa, Yashiroda, Hideki, Murata, Shigeo

“…In eukaryotic cells, the ubiquitin proteasome system plays important roles in diverse cellular processes. The 26S proteasome is a large enzyme complex that…”
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In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals by Bai, Minghui, Zhao, Xian, Sahara, Kazutaka, Ohte, Yuki, Hirano, Yuko, Kaneko, Takeumi, Yashiroda, Hideki, Murata, Shigeo

“…The 26S proteasome is a key player in the degradation of ubiquitinated proteins, comprising a 20S core particle (CP) and a 19S regulatory particle (RP). The RP…”
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The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome by Isono, Erika, Nishihara, Kiyoshi, Saeki, Yasushi, Yashiroda, Hideki, Kamata, Naoko, Ge, Liying, Ueda, Takashi, Kikuchi, Yoshiko, Tanaka, Keiji, Nakano, Akihiko, Toh-e, Akio

“…The 26S proteasome consists of the 20S proteasome (core particle) and the 19S regulatory particle made of the base and lid substructures, and it is mainly…”
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Proteasomes and Molecular Chaperones : Cellular Machinery Responsible for Folding and Destruction of Unfolded Proteins by Imai, Jun, Yashiroda, Hideki, Maruya, Mikako, Yahara, Ichiro, Tanaka, Keiji

“…Molecular chaperones recognize proteins of non-native structure, prevent them from irreversible intracellular aggregation, and then act with regulatory…”
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Assembly mechanisms of specialized core particles of the proteasome by Bai, Minghui, Zhao, Xian, Sahara, Kazutaka, Ohte, Yuki, Hirano, Yuko, Kaneko, Takeumi, Yashiroda, Hideki, Murata, Shigeo

“…The 26S proteasome has a highly complicated structure comprising the 20S core particle (CP) and the 19S regulatory particle (RP). Along with the standard CP in…”
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Hub1 is an essential ubiquitin‐like protein without functioning as a typical modifier in fission yeast by Yashiroda, Hideki, Tanaka, Keiji

“…Hub1 exhibits 23% sequence identity to ubiquitin. However, Hub1 lacks the C‐terminal Gly, which is essential for covalent attachment to target protein(s) of…”
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Proteasome structure and function: from yeast to human by Yashiroda, Hideki, Murata, Shigeo

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Molecular mechanisms of proteasome assembly by Tanaka, Keiji, Murata, Shigeo, Yashiroda, Hideki

“…Key Points The 26S proteasome is a eukaryotic large protein complex that is essential for regulated protein degradation in collaboration with the ubiquitin…”
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Yeast Whi2 and Psr1‐phosphatase form a complex and regulate STRE‐mediated gene expression by Kaida, Daisuke, Yashiroda, Hideki, Toh‐e, Akio, Kikuchi, Yoshiko

“…Background:  In response to various stressful situations, including diauxic conditions, the Msn2 and Msn4 transcription factors induce STRE‐mediated gene…”
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The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions by Yashiroda, Hideki, Kaida, Daisuke, Toh-e, Akio, Kikuchi, Yoshiko

“…The previously identified BUL1 gene was found to encode a protein bound to Rsp5-ubiquitin ligase in budding yeast. We have identified the BUL2 gene as a…”
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Dissecting β-ring assembly pathway of the mammalian 20S proteasome by Hirano, Yuko, Kaneko, Takeumi, Okamoto, Kenta, Bai, Minghui, Yashiroda, Hideki, Furuyama, Kaori, Kato, Koichi, Tanaka, Keiji, Murata, Shigeo

“…The 20S proteasome is the catalytic core of the 26S proteasome. It comprises four stacked rings of seven subunits each, α 1–7 β 1–7 β 1–7 α 1–7 . Recent…”
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