Search Results - "Yashar, William M"

CITEViz: interactively classify cell populations in CITE-Seq via a flow cytometry-like gating workflow using R-Shiny by Kong, Garth L, Nguyen, Thai T, Rosales, Wesley K, Panikar, Anjali D, Cheney, John H W, Lusardi, Theresa A, Yashar, William M, Curtiss, Brittany M, Carratt, Sarah A, Braun, Theodore P, Maxson, Julia E

“…The rapid advancement of new genomic sequencing technology has enabled the development of multi-omic single-cell sequencing assays. These assays profile…”
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Predicting transcription factor activity using prior biological information by Yashar, William M., Estabrook, Joseph, Holly, Hannah D., Somers, Julia, Nikolova, Olga, Babur, Özgün, Braun, Theodore P., Demir, Emek

“…Dysregulation of normal transcription factor activity is a common driver of disease. Therefore, the detection of aberrant transcription factor activity is…”
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A framework for considering prior information in network‐based approaches to omics data analysis by Somers, Julia, Fenner, Madeleine, Kong, Garth, Thirumalaisamy, Dharani, Yashar, William M., Thapa, Kisan, Kinali, Meric, Nikolova, Olga, Babur, Özgün, Demir, Emek

“…Abstract For decades, molecular biologists have been uncovering the mechanics of biological systems. Efforts to bring their findings together have led to the…”
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GoPeaks: histone modification peak calling for CUT&Tag by Yashar, William M, Kong, Garth, VanCampen, Jake, Curtiss, Brittany M, Coleman, Daniel J, Carbone, Lucia, Yardimci, Galip Gürkan, Maxson, Julia E, Braun, Theodore P

“…Genome-wide mapping of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone…”
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Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia by Yashar, William M, Curtiss, Brittany M, Coleman, Daniel J, VanCampen, Jake, Kong, Garth, Macaraeg, Jommel, Estabrook, Joseph, Demir, Emek, Long, Nicola, Bottomly, Daniel, McWeeney, Shannon K, Tyner, Jeffrey W, Druker, Brian J, Maxson, Julia E, Braun, Theodore P

“…Mutations in Fms-like tyrosine kinase 3 (FLT3) are common drivers in acute myeloid leukemia (AML) yet FLT3 inhibitors only provide modest clinical benefit…”
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PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia by Curtiss, Brittany M., VanCampen, Jake, Macaraeg, Jommel, Kong, Garth L., Taherinasab, Akram, Tsuchiya, Mitsuhiro, Yashar, William M., Tsang, Yiu H., Horton, Wesley, Coleman, Daniel J., Estabrook, Joseph, Lusardi, Theresa A., Mills, Gordon B., Druker, Brian J., Maxson, Julia E., Braun, Theodore P.

“…Responses to kinase-inhibitor therapy in AML are frequently short-lived due to the rapid development of resistance, limiting the clinical efficacy. Combination…”
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Differentiation State Plasticity As a Mechanism of BCL2 Inhibitor Resistance in Acute Myeloid Leukemia by Yashar, William M, Tsuchiya, Mitsuhiro, Taherinasab, Akram, Evans-Dutson, Sara, O'Connell, Brendan, Lusardi, Theresa, Szczepanksi, Nicole, Yardimci, Galip Gurkan, Adey, Andrew C, Maxson, Julia E, Braun, Theodore P

“…Acute myeloid leukemia (AML) is composed of a heterogeneous blast population that exhibits characteristics of normal myeloid cells, including immature,…”
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Disruption of the MYC Super-Enhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia by Yashar, William M., Curtiss, Brittany M., Coleman, Daniel J., VanCampen, Jake, Kong, Garth, Macaraeg, Jommel, Estabrook, Joseph, Demir, Emek, Long, Nicola, Bottomly, Daniel, McWeeney, Shannon K., Tyner, Jeffrey W., Druker, Brian J., Maxson, Julia E., Braun, Theodore P.

“…Mutations in Fms-like tyrosine kinase 3 (FLT3) are common drivers in acute myeloid leukemia (AML) yet FLT3 inhibitors only provide modest clinical benefit…”
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GoPeaks: histone modification peak calling for CUT Tag by William M. Yashar, Garth Kong, Jake VanCampen, Brittany M. Curtiss, Daniel J. Coleman, Lucia Carbone, Galip Gürkan Yardimci, Julia E. Maxson, Theodore P. Braun

“…Abstract Genome-wide mapping of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone…”
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Abstract 3269: Dual targeting of FLT3 and LSD1 disrupts the MYC super-enhancer complex in acute myeloid leukemia by Yashar, William M., Smith, Brittany M., VanCampen, Jake, Kong, Garth L., Macaraeg, Jommel, Coleman, Daniel J., Druker, Brian J., Maxson, Julia E., Braun, Theodore P.

“…Abstract Clinical responses to kinase inhibitor therapy in acute myeloid leukemia (AML) are limited by development of resistance. A major contributor of…”
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