Search Results - "Yarranton, Geoffrey"

Antibodies for the treatment of bacterial infections: current experience and future prospects by Bebbington, Christopher, Yarranton, Geoffrey

“…Antibodies can be used for the prevention and treatment of bacterial infections in animal models of disease. Current antibody technology allows the generation…”
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Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment by VAIL, Mary E, MURONE, Carmel, YARRANTON, Geoffrey, LLERENA, Carmen, GARIC, Slavisa, ABRAMSON, David, CARTWRIGHT, Glenn, SCOTT, Andrew M, LACKMANN, Martin, TAN, April, HII, Linda, ABEBE, Degu, JANES, Peter W, LEE, Fook-Thean, BAER, Mark, PALATH, Varghese, BEBBINGTON, Christopher

“…Eph receptor tyrosine kinases are critical for cell-cell communication during normal and oncogenic tissue patterning and tumor growth. Somatic mutation…”
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Engineered Human Antibody Fab Fragment Specific for Pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activity by Baer, Mark, Sawa, Teiji, Flynn, Peter, Luehrsen, Kenneth, Martinez, David, Wiener-Kronish, Jeanine P, Yarranton, Geoffrey, Bebbington, Christopher

“…Pseudomonas aeruginosa is an opportunistic pathogen that can cause acute lung injury and mortality through the delivery of exotoxins by the type III secretion…”
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The eosinophil surface receptor epidermal growth factor–like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders by Legrand, Fanny, PhD, PharmD, Tomasevic, Nenad, PhD, Simakova, Olga, PhD, Lee, Chyi-Chia Richard, MD, PhD, Wang, Zengfang, PhD, Raffeld, Mark, MD, Makiya, Michelle A., MS, Palath, Varghese, PhD, Leung, John, BS, Baer, Mark, PhD, Yarranton, Geoffrey, PhD, Maric, Irina, MD, Bebbington, Christopher, PhD, Klion, Amy D., MD

“…Background Although several novel agents are currently in clinical trials for eosinophilic disorders, none has demonstrated efficacy in reducing blood and…”
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Antibody-mediated depletion of CCR10+EphA3+ cells ameliorates fibrosis in IPF by Hohmann, Miriam S, Habiel, David M, Espindola, Milena S, Huang, Guanling, Jones, Isabelle, Narayanan, Rohan, Coelho, Ana Lucia, Oldham, Justin M, Noth, Imre, Ma, Shwu-Fan, Kurkciyan, Adrianne, McQualter, Jonathan L, Carraro, Gianni, Stripp, Barry, Chen, Peter, Jiang, Dianhua, Noble, Paul W, Parks, William, Woronicz, John, Yarranton, Geoffrey, Murray, Lynne A, Hogaboam, Cory M

“…Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant repair that diminishes lung function via mechanisms that remain poorly understood. CC…”
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Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's Disease and multiple sclerosis by Hemachandra Reddy, P, Manczak, Maria, Zhao, Wei, Nakamura, Kazuhiro, Bebbington, Christopher, Yarranton, Geoffrey, Mao, Peizhong

“…The objective of our study was to determine granulocyte-macrophage colony-stimulating factor (GM-CSF) activity in the brain following GM-CSF induction. We…”
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Binding to CD20 by Anti-B1 Antibody or F(ab')2 is sufficient for induction of apoptosis in B-cell lines by CARDARELLI, Pina M, QUINN, Maire, BUCKMAN, Dana, YU FANG, COLCHER, David, KING, David J, BEBBINGTON, Christopher, YARRANTON, Geoffrey

“…CD20 is a B-cell-specific cell surface protein expressed on mature B lymphocytes and is a target for monoclonal antibody therapy for non-Hodgkin's lymphoma…”
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A Randomized Placebo-Controlled Safety and Pharmacodynamic Study of KB002, a Chimeric Anti-GM-CSF Monoclonal Antibody, in Patients with Asthma by Molfino, Nestor A., MD, MSc, Bardin, Philip G., MD, PhD, Thompson, Philip J., MD, Luckey, Alison, BM, DPM, Yarranton, Geoffrey, PhD

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CPI-0004Na, a new extracellularly tumor-activated prodrug of doxorubicin: In vivo toxicity, activity, and tissue distribution confirm tumor cell selectivity by DUBOIS, Vincent, DASNOIS, Luc, SHOCHAT, Dan, YARRANTON, Geoffrey T, TROUET, André, LEBTAHI, Karim, COLLOT, Francoise, HEYLEN, Nathalie, HAVAUX, Nathalie, FERNANDEZ, Anne-Marie, LOBL, Thomas J, OLIYAI, Cecilia, NIEDER, Matthew

“…The search for cancer therapies that are more selective for tumor cells and spare normal sensitive cells has been very active for at least 20 years. The…”
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CD10 is a key enzyme involved in the activation of tumor-activated peptide prodrug CPI-0004Na and novel analogues: Implications for the design of novel peptide prodrugs for the therapy of CD10+ tumors by CHIN PAN, CARDARELLI, Pina M, SALLES, Adam, CHEN, Tseng-Hui, HORGAN, Killian, WANG, Yi-Hong, THI NGUYEN, BEBBINGTON, Christopher R, NIEDER, Matthew H, PICKFORD, Lesley B, GANGWAR, Sanjeev, KING, David J, YARRANTON, Geoffrey T, BUCKMAN, Dana, ROSCOE, William, FENGMIN ZHOU

“…Traditional chemotherapeutic drugs are often restricted by severe side effects and lack of tumor specificity. Peptide prodrugs cleavable by peptidases present…”
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Improved tumor targeting with chemically cross-linked recombinant antibody fragments by KING, D. J, TURNER, A, MILLAR, K, MILLICAN, T. A, BOYCE, B. A, ANTONIW, P, MOUNTAIN, A, BEGENT, R. H. J, SHOCHAT, D, YARRANTON, G. T, FARNSWORTH, A. P. H, ADAIR, J. R, OWENS, R. J, PEDLEY, R. B, BALDOCK, D, PROUDFOOT, K. A, LAWSON, A. D. G, BEELEY, N. R. A

“…The construction and use of recombinant chimeric and later fully humanized (CDR-grafted) antibodies to tumor-associated antigens has reduced the immune…”
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GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia by Padron, Eric, Painter, Jeffrey S., Kunigal, Sateesh, Mailloux, Adam W., McGraw, Kathy, McDaniel, Jessica M., Kim, Eunhee, Bebbington, Christopher, Baer, Mark, Yarranton, Geoffrey, Lancet, Jeffrey, Komrokji, Rami S., Abdel-Wahab, Omar, List, Alan F., Epling-Burnette, Pearlie K.

“…Granulocyte-macrophage–colony-stimulating factor (GM-CSF) hypersensitivity is a hallmark of juvenile myelomonocytic leukemia (JMML) but has not been…”
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Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: A randomized,double-blind, placebo-controlled trial by François, Bruno, Luyt, Charles-Edouard, Dugard, Anthony, Wolff, Michel, Diehl, Jean-Luc, Jaber, Samir, Forel, Jean-Marie, Garot, Denis, Kipnis, Eric, Mebazaa, Alexandre, Misset, Benoit, Andremont, Antoine, Ploy, Marie-Cécile, Jacobs, Alan, Yarranton, Geoffrey, Pearce, Tillman, Fagon, Jean-Yves, Chastre, Jean

“…OBJECTIVE:The type III secretion system is an important Pseudomonas aeruginosa-virulence determinant in animal models of infection and in humans…”
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Anti-PcrV antibody in cystic fibrosis: A novel approach targeting Pseudomonas aeruginosa airway infection by Milla, Carlos E., Chmiel, James F., Accurso, Frank J., VanDevanter, Donald R., Konstan, Michael W., Yarranton, Geoffrey, Geller, David E.

“…Summary Pseudomonas aeruginosa (Pa) airway infection is associated with increased morbidity and mortality in cystic fibrosis (CF). The type III secretion…”
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Phase 2, randomised placebo-controlled trial to evaluate the efficacy and safety of an anti-GM-CSF antibody (KB003) in patients with inadequately controlled asthma by Molfino, Nestor A, Kuna, Piotr, Leff, Jonathan A, Oh, Chad K, Singh, Dave, Chernow, Marlene, Sutton, Brian, Yarranton, Geoffrey

“…ObjectivesWe wished to evaluate the effects of an antigranulocyte-macrophage colony-stimulating factor monoclonal antibody (KB003) on forced expiratory volume…”
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An IHC Screen For EphA3 Positive FFPE Tumors by Locke, Darren, Bernstein, Steven, Lynch, Frank, Siami-Namini, Koushan, Walling, Jackie M., Yonker, Thomas, Yarranton, Geoffrey

“…Eph receptors are the largest subgroup of the receptor tyrosine kinases (RTK). Unlike other RTK, these function principally during development. Quiescent in…”
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Anti-PcrV antibody in cystic fibrosis: A novel approach targeting Pseudomonas aeruginosa airway infection: An Anti-Pseudomonal Antibody Fragment in CF by Milla, Carlos E., Chmiel, James F., Accurso, Frank J., VanDevanter, Donald R., Konstan, Michael W., Yarranton, Geoffrey, Geller, David E.

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Analysis Of EphA3 Expression In Hematologic Malignancies By Quantitative PCR by Woronicz, John, Cortes, Jorge E., Jorgensen, Jeffrey L., Kantarjian, Hagop M, Ravandi, Farhad, Borthakur, Gautam, Challagundla, Pramoda, Matthews, Jairo, Ho, Jennifer, Walling, Jackie M., Yarranton, Geoffrey, Pemmaraju, Naveen

“…EphA3 is a receptor tyrosine kinase that plays an important role in cell positioning and tissue organization during fetal development, but is not thought to…”
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A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity by Tomasevic, Nenad, Luehrsen, Kenneth, Baer, Mark, Palath, Varghese, Martinez, David, Williams, Jason, Yi, Christina, Sujatha-Bhaskar, Swathi, Lanke, Rohini, Leung, John, Ching, Wendy, Lee, Andreia, Bai, Lu, Yarranton, Geoffrey, Bebbington, Christopher

“…Abstract EphA3is expressed in solid tumors and leukemias and is an attractive target for the therapy. We have generated a panel of Humaneered® antibodies to…”
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Eosinophil surface receptor EMR1: a novel therapeutic target for eosinophilic disorders by Legrand, Fanny, Tomasevic, Nenad, Simakova, Olga, Lee, Chyi-Chia Richard, Wang, Zengfang, Raffeld, Mark, Makiya, Michelle A., Palath, Varghese, Leung, John, Baer, Mark, Yarranton, Geoffrey, Maric, Irina, Bebbington, Christopher, Klion, Amy D.

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