Search Results - "Yarovoi, Serge"

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes by Khandelwal, Sanjay, Barnes, Ayiesha, Rauova, Lubica, Sarkar, Amrita, Rux, Ann H., Yarovoi, Serge V., Zaitsev, S. Sergei, Lambris, John D., Myoung, Sooho S., Johnson, Alexandra, Lee, Grace M., Duarte, Madelaine, Poncz, Mortimer, Arepally, Gowthami M., Cines, Douglas B.

“…Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by ultra-large immune complexes (ULICs) containing immunoglobulin G (IgG)…”
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Atomic description of the immune complex involved in heparin-induced thrombocytopenia by Cai, Zheng, Yarovoi, Serge V., Zhu, Zhiqiang, Rauova, Lubica, Hayes, Vincent, Lebedeva, Tatiana, Liu, Qun, Poncz, Mortimer, Arepally, Gowthami, Cines, Douglas B., Greene, Mark I.

“…Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by immune complexes containing platelet factor 4 (PF4), antibodies to PF4…”
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Modulation of ultralarge immune complexes in heparin–induced thrombocytopenia by Cai, Zheng, Bdeir, Khalil, Yarovoi, Serge V., Rauova, Lubica, Arepally, Gowthami M., Khandelwal, Sanjay, Rollin, Jerome, Gruel, Yves, Zaitsev, Sergei, Poncz, Mortimer, Greene, Mark I., Cines, Douglas B.

“…Heparin–induced thrombocytopenia (HIT) is a serious thrombotic disorder caused by ultralarge immune complexes (ULICs) containing platelet factor 4 (PF4) and…”
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Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice by Hijazi, Nuha, Abu Fanne, Rami, Abramovitch, Rinat, Yarovoi, Serge, Higazi, Muhamed, Abdeen, Suhair, Basheer, Maamon, Maraga, Emad, Cines, Douglas B., Al-Roof Higazi, Abd

“…Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is…”
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Dynamic antibody-binding properties in the pathogenesis of HIT by Sachais, Bruce S., Litvinov, Rustem I., Yarovoi, Serge V., Rauova, Lubica, Hinds, Jillian L., Rux, Ann H., Arepally, Gowthami M., Poncz, Mortimer, Cuker, Adam, Weisel, John W., Cines, Douglas B.

“…Rapid laboratory assessment of heparin-induced thrombocytopenia (HIT) is important for disease recognition and management. The utility of contemporary…”
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Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits by Florova, Galina, Azghani, Ali O, Karandashova, Sophia, Schaefer, Chris, Yarovoi, Serge V, Declerck, Paul J, Cines, Douglas B, Idell, Steven, Komissarov, Andrey A

“…Elevated active plasminogen activator inhibitor-1 (PAI-1) has an adverse effect on the outcomes of intrapleural fibrinolytic therapy (IPFT) in…”
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Novel diagnostic assays for heparin-induced thrombocytopenia by Cuker, Adam, Rux, Ann H., Hinds, Jillian L., Dela Cruz, May, Yarovoi, Serge V., Brown, Isola A.M., Yang, Wei, Konkle, Barbara A., Arepally, Gowthami M., Watson, Stephen P., Cines, Douglas B., Sachais, Bruce S.

“…Laboratory testing for heparin-induced thrombocytopenia (HIT) has important shortcomings. Immunoassays fail to discriminate platelet-activating from…”
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Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia by Cines, Douglas B., Yarovoi, Serge V., Zaitsev, Sergei V., Lebedeva, Tatiana, Rauova, Lubica, Poncz, Mortimer, Arepally, Gowthami M., Khandelwal, Sanjay, Stepanova, Victoria, Rux, Ann H., Cuker, Adam, Guo, Cecilia, Ocariza, Linnette Mae, Travers, Richard J., Smith, Stephanie A., Kim, Hugh, Morrissey, James H., Conway, Edward M.

“…Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of…”
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Distinct Specificity and Single-molecule Kinetics Characterize the Interaction of Pathogenic and Non-pathogenic Antibodies against Platelet Factor 4-Heparin Complexes with Platelet Factor 4 by Litvinov, Rustem I., Yarovoi, Serge V., Rauova, Lubica, Barsegov, Valeri, Sachais, Bruce S., Rux, Ann H., Hinds, Jillian L., Arepally, Gowthami M., Cines, Douglas B., Weisel, John W.

“…Heparin-induced thrombocytopenia (HIT) is a thrombotic complication of heparin therapy mediated by antibodies to complexes between platelet factor 4 (PF4) and…”
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Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia by Sachais, Bruce S., Rux, Ann H., Cines, Douglas B., Yarovoi, Serge V., Garner, Lee I., Watson, Stephen P., Hinds, Jillian L., Rux, John J.

“…Patients with heparin-induced thrombocytopenia (HIT) remain at risk for recurrent thromboembolic complications despite improvements in management. HIT is…”
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RETRACTED ARTICLE: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK by Armstead, William M, Hekierski, Hugh, Pastor, Philip, Yarovoi, Serge, Higazi, Abd Al-Roof, Cines, Douglas B

“…The sole FDA-approved drug treatment for ischemic stroke is tissue-type plasminogen activator (tPA). However, upregulation of JNK mitogen-activated protein…”
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Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration by Kapustin, Alexander, Stepanova, Victoria, Aniol, Natalia, Cines, Douglas B, Poliakov, Alexei, Yarovoi, Serge, Lebedeva, Tatiana, Wait, Robin, Ryzhakov, Grigory, Parfyonova, Yelena, Gursky, Yaroslav, Yanagisawa, Hiromi, Minashkin, Mikhail, Beabealashvilli, Robert, Vorotnikov, Alexander, Bobik, Alex, Tkachuk, Vsevolod

“…uPA (urokinase-type plasminogen activator) stimulates cell migration through multiple pathways, including formation of plasmin and extracellular…”
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Signal Recognition Particle Components in the Nucleolus by Politz, Joan C., Yarovoi, Serge, Kilroy, Susan M., Gowda, Krishne, Zwieb, Christian, Pederson, Thoru

“…The signal recognition particle (SRP) is a ribonucleoprotein composed of an Alu domain and an S domain. The S domain contains unique sequence SRP RNA and four…”
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Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis by Sarkar, Amrita, Khandelwal, Sanjay, Yarovoi, Serge, Arepally, Gowthami M., Cines, Douglas B., Poncz, Mortimer, Rauova, Lubica

“…Heparin induced thrombocytopenia (HIT) is an immunogenic prothrombotic disorder caused by antibodies that recognize human platelet factor 4 (PF4) complexed to…”
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Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia by Rauova, Lubica, Bdeir, Khalil, Cai, Zheng, Yarovoi, Serge, Arepally, Gowthami M., Khandelwal, Sanjay, Poncz, Mortimer, Greene, Mark, Cines, Douglas B.

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Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK by Armstead, William M., Hekierski, Hugh, Pastor, Philip, Yarovoi, Serge, Higazi, Abd Al-Roof, Cines, Douglas B.

“…The sole FDA-approved drug treatment for ischemic stroke is tissue-type plasminogen activator (tPA). However, upregulation of JNK mitogen-activated protein…”
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Retraction Note: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK by Armstead, William M, Hekierski, Hugh, Pastor, Philip, Yarovoi, Serge, Higazi, Abd Al-Roof, Cines, Douglas B

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Complement Regulates the Procoagulant Effects of HIT Immune Complexes by Khandelwal, Sanjay, Rauova, Lubica, Barnes, Ayiesha, Rux, Ann, Yarovoi, Serge, Myoung, Sooho S, Johnson, Alexandra, Lee, Grace M, Duarte, Madelaine, Poncz, Mortimer, Arepally, Gowthami M., Cines, Douglas B.

“…Heparin induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by ultra-large immune complexes (ULICs) containing IgG antibodies bound to…”
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Abstract TP251: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK by Armstead, William M, Hekierski, Hugh, Pastor, Philip, Yarovoi, Serge, Higazi, Abd Al Roof, Cines, Douglas

“…Abstract only Introduction: The sole FDA approved drug treatment for acute stroke is tissue type plasminogen activator (tPA). However, its brief therapeutic…”
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Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications by Rauova, Lubica, Wang, Andy, Yarovoi, Serge, Khandelwal, Sanjay, Padmanabhan, Anand, Oleshko, Olga, Charman, Matthew J., Tiede, Andreas, Abrams, Charles S., Weitzman, Matthew D., Arepally, Gowthami M., Cines, Douglas B., Poncz, Mortimer

“…VITT is an immune-based complication of adenoviral-based vaccines used to immunize against SARS_CoV2. The antibodies in VITT have been described as directed at…”
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