Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

Summary Inconsistent results of association studies investigated the role of glutathione S–transferase genes in idiopathic male infertility may be explained by ethnical differences in gene–gene and gene–environment interactions. In this study, we investigated a joint contribution of GSTM1, GSTT1 and...

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Published in:	Andrologia Vol. 47; no. 9; pp. 980 - 986
Main Authors:	Yarosh, S. L., Kokhtenko, E. V., Churnosov, M. I., Solodilova, M. A., Polonikov, A. V.
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 01-11-2015 Wiley Subscription Services, Inc
Subjects:	Adult Case-Control Studies Cigarette smoking European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Gene-Environment Interaction gene-environment interactions gene-gene interactions Genes Genotype glutathione S-transferase Glutathione S-Transferase pi - genetics Glutathione Transferase - genetics Humans idiopathic male infertility Infertility, Male - epidemiology Infertility, Male - genetics Male Polymerase Chain Reaction Polymorphism Polymorphism, Restriction Fragment Length Russia - epidemiology Smoking Smoking - epidemiology Russia idiopathic male infertility Cigarette smoking gene-environment interactions glutathione S-transferase gene-gene interactions
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Summary:	Summary Inconsistent results of association studies investigated the role of glutathione S–transferase genes in idiopathic male infertility may be explained by ethnical differences in gene–gene and gene–environment interactions. In this study, we investigated a joint contribution of GSTM1, GSTT1 and GSTP1 gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men. DNA samples from 203 infertile and 227 fertile men were genotyped by a multiplex polymerase chain reaction (GSTM1 and GSTT1 deletions) and PCR‐restriction fragment length polymorphism (GSTP1 I105V) methods. The GSTP1 genotype 105IV was associated with increased risk of male infertility (OR = 1.50 95% CI 1.02–2.20 P = 0.04). Genotype combinations GSTP1 105II/GSTT1 del (G1), GSTM1 del/GSTT1 del (G2) and GSTM1 + /GSTT1 del (G3) were associated with decreased risk of male infertility (P ≤ 0.003), whereas a genotype combination GSTP1 105IV/GSTT1 + (G4) was associated with increased disease risk (P = 0.001). The genotype combinations G3 and G4 showed a significant association with infertility in smokers; however, nonsmokers carriers did show the disease risk. In conclusion, GSTM1, GSTT1 and GSTP1 genes are collectively involved in the development of idiopathic male infertility and their phenotypic effects on the disease risk are potentiated by cigarette smoking.
Bibliography:	istex:995F2429962BE6126B20D9665AE2B760ACBD3D40 ark:/67375/WNG-3QH7B6H8-Z ArticleID:AND12367 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0303-4569 1439-0272
DOI:	10.1111/and.12367