Search Results - "Yarmush, M.L"

Subnormothermic Machine Perfusion for Ex Vivo Preservation and Recovery of the Human Liver for Transplantation by Bruinsma, B. G., Yeh, H., Özer, S., Martins, P. N., Farmer, A., Wu, W., Saeidi, N., Op den Dries, S., Berendsen, T. A., Smith, R. N., Markmann, J. F., Porte, R. J., Yarmush, M. L., Uygun, K., Izamis, M.‐L.

“…To reduce widespread shortages, attempts are made to use more marginal livers for transplantation. Many of these grafts are discarded for fear of inferior…”
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Perfusion Defatting at Subnormothermic Temperatures in Steatotic Rat Livers by Liu, Q, Berendsen, T, Izamis, M.-L, Uygun, B, Yarmush, M.L, Uygun, K

“…Abstract Hepatic steatosis is a major risk factor in liver transplantation. Use of machine perfusion to reduce steatosis has been reported previously at…”
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Polyethylene glycol protects primary hepatocytes during supercooling preservation by Puts, C.F., Berendsen, T.A., Bruinsma, B.G., Ozer, Sinan, Luitje, Martha, Usta, O. Berk, Yarmush, M.L., Uygun, K.

“…Cold storage (at 4°C) offers a compromise between the benefits and disadvantages of cooling. It allows storage of organs or cells for later use that would…”
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Hepatocyte Viability and Adenosine Triphosphate Content Decrease Linearly Over Time During Conventional Cold Storage of Rat Liver Grafts by Berendsen, T.A, Izamis, M.L, Xu, H, Liu, Q, Hertl, M, Berthiaume, F, Yarmush, M.L, Uygun, K

“…Abstract Introduction The gold standard in organ preservation is static cold storage (SCS) using University of Wisconsin solution (UW). Although it is…”
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Molecular machines by Mavroidis, C, Dubey, A, Yarmush, M L

“…Molecular machines are tiny energy conversion devices on the molecular-size scale. Whether naturally occurring or synthetic, these machines are generally more…”
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Sodium butyrate-treated embryonic stem cells yield hepatocyte-like cells expressing a glycolytic phenotype by Sharma, N.S., Shikhanovich, R., Schloss, R., Yarmush, M.L.

“…Embryonic stem cells serve as a promising technology to obtain specific cell types for a number of biomedical applications. Because traditional techniques,…”
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Microfabrication of Hepatocyte/Fibroblast Co-cultures: Role of Homotypic Cell Interactions by Bhatia, S. N., Balis, U. J., Yarmush, M. L., Toner, M.

“…Cell−cell interactions are important in embryogenesis, in adult physiology and pathophysiology of many disease processes. Co‐cultivation of parenchymal and…”
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Sequential Cold Storage and Normothermic Perfusion of the Ischemic Rat Liver by Tolboom, H, Milwid, J.M, Izamis, M.L, Uygun, K, Berthiaume, F, Yarmush, M.L

“…Abstract Extending transplant criteria to include livers obtained from donors after cardiac death (DCD) could increase the liver donor pool, but conventional…”
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Isolation rearing significantly perturbs brain metabolism in the thalamus and hippocampus by Bonab, A.A, Fricchione, J.G, Gorantla, S, Vitalo, A.G, Auster, M.E, Levine, S.J, Scichilone, J.M, Hegde, M, Foote, W, Fricchione, G.L, Denninger, J.W, Yarmush, D.M, Fischman, A.J, Yarmush, M.L, Levine, J.B

“…Highlights ► Isolation-reared (IR) rats had decreased PET FDG uptake in the hippocampus and the thalamus. ► The decreased FDG uptake of IR rats in the…”
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Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats by Levine, J.B, Leeder, A.D, Parekkadan, B, Berdichevsky, Y, Rauch, S.L, Smoller, J.W, Konradi, C, Berthiaume, F, Yarmush, M.L

“…Abstract In addition to its maladaptive effects on psychiatric function, psychosocial deprivation impairs recovery from physical illness. Previously, we found…”
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Diluted Blood Reperfusion as a Model for Transplantation of Ischemic Rat Livers: Alanine Aminotransferase Is a Direct Indicator of Viability by Uygun, K, Tolboom, H, Izamis, M.L, Uygun, B, Sharma, N, Yagi, H, Soto-Gutierrez, A, Hertl, M, Berthiaume, F, Yarmush, M.L

“…Abstract Donors after cardiac death present a significant pool of untapped organs for transplantation, and use of machine perfusion strategies has been an…”
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Probing heterotypic cell interactions: Hepatocyte function in microfabricated co-cultures by Bhatia, S.N., Balis, U.J., Yarmush, M.L., Toner, M.

“…Replacement of liver function using extracorporeal bioartificial systems has been attempted with limited success. The instability of the hepatocyte phenotype…”
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Large-Scale Processing of Recombinant Retroviruses for Gene Therapy by Andreadis, Stylianos T., Roth, Charles M., Le Doux, Joseph M., Morgan, Jeffrey R., Yarmush, Martin L.

“…Gene therapy is a new therapeutic modality with the potential of treating inherited and acquired diseases. Several viral and physicochemical vehicles have been…”
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Nucleation and growth of ice crystals inside cultured hepatocytes during freezing in the presence of dimethyl sulfoxide by Karlsson, J.O., Cravalho, E.G., Borel Rinkes, I.H., Tompkins, R.G., Yarmush, M.L., Toner, M.

“…A three-part, coupled model of cell dehydration, nucleation, and crystal growth was used to study intracellular ice formation (IIF) in cultured hepatocytes…”
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Dynamics of cell membrane permeability changes at supraphysiological temperatures by Bischof, J.C., Padanilam, J., Holmes, W.H., Ezzell, R.M., Lee, R.C., Tompkins, R.G., Yarmush, M.L., Toner, M.

“…A quantitative fluorescent microscopy system was developed to characterize, in real time, the effects of supraphysiological temperatures between 37 degrees and…”
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Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human by Chao, P., Maguire, T., Novik, E., Cheng, K.-C., Yarmush, M.L.

“…Integral to the discovery of new pharmaceutical entities is the ability to predict in vivo pharmacokinetic parameters from early stage in vitro data generated…”
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Effects of Hypothermia on the Function, Membrane Integrity, and Cytoskeletal Structure of Hepatocytes by Stefanovich, P., Ezzell, R.M., Sheehan, S.J., Tompkins, R.G., Yarmush, M.L., Toner, M.

“…To increase the storage time of livers for transplantation, a better understanding of hypothermia-induced hepatocyte damage is necessary. To this end, we have…”
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Sleeve gastrectomy and Roux-en-Y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats by Saeidi, N, Nestoridi, E, Kucharczyk, J, Uygun, M K, Yarmush, M L, Stylopoulos, N

“…Objective: All available treatments directed towards obesity and obesity-related complications are associated with suboptimal effectiveness/invasiveness…”
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Liver Defatting: An Alternative Approach to Enable Steatotic Liver Transplantation by Nativ, N. I., Maguire, T. J., Yarmush, G., Brasaemle, D. L., Henry, S. D., Guarrera, J. V., Berthiaume, F., Yarmush, M. L.

“…Macrovesicular steatosis in greater than 30% of hepatocytes is a significant risk factor for primary graft nonfunction due to increased sensitivity to ischemia…”
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Induction of Tolerance to Hypothermia by Previous Heat Shock Using Human Fibroblasts in Culture by Russotti, G., Brieva, T.A., Toner, M., Yarmush, M.L.

“…The technique of organ preservation is limited by the amount of time which organs can be hypothermically stored. A potential method to effectively extend…”
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