Search Results - "Yarlagadda, Sunitha"

Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders by Shik Mun, Kyu, Arora, Kavisha, Huang, Yunjie, Yang, Fanmuyi, Yarlagadda, Sunitha, Ramananda, Yashaswini, Abu-El-Haija, Maisam, Palermo, Joseph J., Appakalai, Balamurugan N., Nathan, Jaimie D., Naren, Anjaparavanda P.

“…Cystic fibrosis (CF) is a genetic disorder caused by defective CF Transmembrane Conductance Regulator (CFTR) function. Insulin producing pancreatic islets are…”
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Characterizing post-branching nephrogenesis in the neonatal rabbit by Schuh, Meredith P., Yarlagadda, Sunitha, Alkhudairy, Lyan, Preusse, Kristina, Kopan, Raphael

“…Human nephrogenesis ends prior to birth in term infants (34–36 week gestation), with most (60%) nephrons forming in late gestation in two post-branching…”
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Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR by Huang, Yunjie, Arora, Kavisha, Mun, Kyu Shik, Yang, Fanmuyi, Moon, ChangSuk, Yarlagadda, Sunitha, Jegga, Anil, Weaver, Timothy, Naren, Anjaparavanda P.

“…The molecular mechanism of Endoplasmic Reticulum-associated degradation (ERAD) of Cystic fibrosis transmembrane-conductance regulator (CFTR) is largely…”
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Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why? by Arora, Kavisha, Sinha, Chandrima, Zhang, Weiqiang, Ren, Aixia, Moon, Chang Suk, Yarlagadda, Sunitha, Naren, Anjaparavanda P.

“…Preciseness of cellular behavior depends upon how an extracellular cue mobilizes a correct orchestra of cellular messengers and effector proteins spatially and…”
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Compartmentalized Accumulation of cAMP near Complexes of Multidrug Resistance Protein 4 (MRP4) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Contributes to Drug-induced Diarrhea by Moon, Changsuk, Zhang, Weiqiang, Ren, Aixia, Arora, Kavisha, Sinha, Chandrima, Yarlagadda, Sunitha, Woodrooffe, Koryse, Schuetz, John D., Valasani, Koteswara Rao, de Jonge, Hugo R., Shanmukhappa, Shiva Kumar, Shata, Mohamed Tarek M., Buddington, Randal K., Parthasarathi, Kaushik, Naren, Anjaparavanda P.

“…Diarrhea is one of the most common adverse side effects observed in ∼7% of individuals consuming Food and Drug Administration (FDA)-approved drugs. The…”
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The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation[S] by Bolen, Alyssa L., Naren, Anjaparavanda P., Yarlagadda, Sunitha, Beranova-Giorgianni, Sarka, Chen, Li, Norman, Derek, Baker, Daniel L., Rowland, Meng M., Best, Michael D., Sano, Takamitsu, Tsukahara, Tamotsu, Liliom, Karoly, Igarashi, Yasuyuki, Tigyi, Gabor

“…Platelet activation initiates an upsurge in polyun­saturated (18:2 and 20:4) lysophosphatidic acid (LPA) production. The biochemical pathway(s) responsible for…”
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Guanylate cyclase 2C agonism corrects CFTR mutants by Arora, Kavisha, Huang, Yunjie, Mun, Kyushik, Yarlagadda, Sunitha, Sundaram, Nambirajan, Kessler, Marco M, Hannig, Gerhard, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Helmrath, Michael, Palermo, Joseph J, Clancy, John P, Steinbrecher, Kris A, Naren, Anjaparavanda P

“…Cystic fibrosis (CF) is a genetic disorder in which epithelium-generated fluid flow from the lung, intestine, and pancreas is impaired due to mutations…”
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Evidence for Post-Branching Nephrogenesis and Novel Ureteric Bud/Nephron Progenitor Interaction in the Postnatal Rabbit: FR-PO392 by Schuh, Meredith P., Yarlagadda, Sunitha, Alkhudairy, Lyan, Kopan, Raphael

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Elexacaftor/Tezacaftor/Ivacaftor Improved Clinical Outcomes in a Patient with N1303K-CFTR Based on In Vitro Experimental Evidence by Huang, Yunjie, Paul, Grace, Lee, Jesun, Yarlagadda, Sunitha, McCoy, Karen, Naren, Anjaparavanda P

“…Huang et al discuss their study on the use of a new generation of cystic fibrosis transmembrane conductance regulator (CFTR) protein modulator in patients with…”
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586 ER LUMINAL ERAD AS A NOVEL TARGET TO RESCUE MUTANT CFTR IN THE INTESTINE by Huang, Yunjie, Arora, Kavisha, Mun, Kyu Shik, Yang, Fanmuyi, Yarlagadda, Sunitha, Jegga, Anil, Weaver, Timothy E., Naren, Anjaparavanda P.

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A personalized medicine approach to optimize care for a pediatric cystic fibrosis patient with atypical clinical symptoms by Lee, Jesun, Husami, Ammar, Arora, Kavisha, Zhang, Weiqiang, Kadri, Ferdous, Yarlagadda, Sunitha, Moon, Changsuk, Mun, Kyu Shik, Zhang, Kejian, Huang, Yunjie, Liyanage, Pramodha, Brewington, John, Clancy, John P., Shaikhkhalil, Ala, Paul, Grace, Naren, Anjaparavanda P.

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Drug-induced secretory diarrhea: A role for CFTR by Moon, Changsuk, Zhang, Weiqiang, Sundaram, Nambirajan, Yarlagadda, Sunitha, Reddy, Vadde Sudhakar, Arora, Kavisha, Helmrath, Michael A., Naren, Anjaparavanda P.

“…[Display omitted] Many medications induce diarrhea as a side effect, which can be a major obstacle to therapeutic efficacy and also a life-threatening…”
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Human Nephrogenesis can Persist Beyond 40 Postnatal Days in Preterm Infants by Carpenter, James, Yarlagadda, Sunitha, VandenHeuvel, Katherine A, Ding, Lili, Schuh, Meredith P

“…Human nephrogenesis is typically completed by 36 weeks gestation; however, it is impacted by preterm birth. Early studies suggested that nephrogenesis…”
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Stabilizing Rescued Surface-Localized ΔF508 CFTR by Potentiation of Its Interaction with Na+/H+ Exchanger Regulatory Factor 1 by Arora, Kavisha, Moon, Changsuk, Zhang, Weiqiang, Yarlagadda, Sunitha, Penmatsa, Himabindu, Ren, Aixia, Sinha, Chandrima, Naren, Anjaparavanda P

“…Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in CFTR, a plasma-membrane-localized anion channel. The most common mutation in CFTR,…”
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Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation by Arora, Kavisha, Yarlagadda, Sunitha, Zhang, Weiqiang, Moon, ChangSuk, Bouquet, Erin, Srinivasan, Saumini, Li, Chunying, Stokes, Dennis C, Naren, Anjaparavanda P

“…Cystic fibrosis (CF) is a life-shortening disease caused by the mutations that generate nonfunctional CF transmembrane conductance regulator (CFTR) protein. A…”
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Förster Resonance Energy Transfer — An approach to visualize the spatiotemporal regulation of macromolecular complex formation and compartmentalized cell signaling by Sinha, Chandrima, Arora, Kavisha, Moon, Chang Suk, Yarlagadda, Sunitha, Woodrooffe, Koryse, Naren, Anjaparavanda P.

“…Signaling messengers and effector proteins provide an orchestrated molecular machinery to relay extracellular signals to the inside of cells and thereby…”
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Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides by Sinha, Chandrima, Ren, Aixia, Arora, Kavisha, Moon, Chang-Suk, Yarlagadda, Sunitha, Zhang, Weiqiang, Cheepala, Satish B., Schuetz, John D., Naren, Anjaparavanda P.

“…It has long been known that cyclic nucleotides and cyclic nucleotide-dependent signaling molecules control cell migration. However, the concept that it is not…”
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Altered cGMP Dynamics at the Plasma Membrane Contribute to Diarrhea in Ulcerative Colitis by Arora, Kavisha, Sinha, Chandrima, Zhang, Weiqiang, Moon, Chang Suk, Ren, Aixia, Yarlagadda, Sunitha, Dostmann, Wolfgang R, Adebiyi, Adebowale, Haberman, Yael, Denson, Lee A, Wang, Xusheng, Naren, Anjaparavanda P

“…Ulcerative colitis (UC) belongs to inflammatory bowel disorders, a group of gastrointestinal disorders that can produce serious recurring diarrhea in affected…”
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Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry by Sinha, Chandrima, Zhang, Weiqiang, Moon, Chang Suk, Actis, Marcelo, Yarlagadda, Sunitha, Arora, Kavisha, Woodroofe, Koryse, Clancy, John P., Lin, Songbai, Ziady, Assem G., Frizzell, Raymond, Fujii, Naoaki, Naren, Anjaparavanda P.

“…Cystic fibrosis (CF) is a lethal genetic disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel. F508del is the…”
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PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration by Sinha, Chandrima, Ren, Aixia, Arora, Kavisha, Moon, Chang Suk, Yarlagadda, Sunitha, Woodrooffe, Koryse, Lin, Songbai, Schuetz, John D, Ziady, Assem G, Naren, Anjaparavanda P

“…Multidrug resistance protein 4 (MRP4), a member of the ATP binding cassette transporter family, functions as a plasma membrane exporter of cyclic nucleotides…”
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