Effects of recombinant human growth hormone and nandrolone phenylpropionate on the healing of ischemic colon anastomosis in rats

Recombinant human growth hormone and nandrolone phenylpropionate are two different anabolic agents. This study was designed to investigate the effects of these anabolic agents on the healing of ischemic colon anastomosis in rats. Seventy adult male Wistar rats were divided into five groups (n = 14)....

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Bibliographic Details
Published in:	Diseases of the colon & rectum Vol. 46; no. 12; p. 1690
Main Authors:	Yarimkaya, Ali, Apaydin, Berat, Unal, Ethem, Karabicak, Ilhan, Aydogan, Fatih, Uslu, Ezel, Erginoz, Ethem, Artis, Tarik, Eyuboglu, Erhun
Format:	Journal Article
Language:	English
Published:	United States 01-12-2003
Subjects:	Anastomosis, Surgical Animals Colon - blood supply Colon - surgery Disease Models, Animal Human Growth Hormone - pharmacology Ischemia - etiology Ischemia - prevention & control Male Nandrolone - analogs & derivatives Nandrolone - pharmacology Rats Rats, Wistar Wound Healing
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Summary:	Recombinant human growth hormone and nandrolone phenylpropionate are two different anabolic agents. This study was designed to investigate the effects of these anabolic agents on the healing of ischemic colon anastomosis in rats. Seventy adult male Wistar rats were divided into five groups (n = 14). Group I was the sham laparotomy group. In the other groups, surgical procedures consisting of transsection and anastomosis were made at a distance 3 cm from the peritoneal reflection. Group II was the nonischemic control group. Ischemic colon model was produced in the remaining groups. Group III was the untreated control group. Groups IV and V received recombinant human growth hormone and nandrolone phenylpropionate, respectively. Bursting pressure and hydroxyproline levels were measured on the third and seventh postoperative days to evaluate anastomotic healing. Recombinant human growth hormone increased both collagen deposition and bursting pressure significantly at postoperative Days 3 and 7 compared with the sham and untreated control groups (P < 0.005). When compared with the untreated control, nandrolone phenylpropionate significantly increased collagen deposition at postoperative Days 3 and 7 (P < 0.005) and bursting pressure only at postoperative Day 3 (P < 0.005). Recombinant human growth hormone has more favorable therapeutic effects on the healing of ischemic colonic anastomoses than nandrolone phenylpropionate. Recombinant human growth hormone also improves healing of nonischemic colonic anastomosis.
ISSN:	0012-3706
DOI:	10.1007/BF02660777