Search Results - "Yapp, Donald T T"

Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer by CHITTARANJAN, Suganthi, BORTNIK, Svetlana, YAPP, Donald T, BALLY, Marcel B, GORSKI, Sharon M, DRAGOWSKA, Wieslawa H, JING XU, ABEYSUNDARA, Namal, LEUNG, Amy, GO, Nancy E, DEVORKIN, Lindsay, WEPPLER, Sherry A, GELMON, Karen

“…Triple-negative breast cancers (TNBC) are defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth…”
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Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy by van Ballegooie, Courtney, Man, Alice, Win, Mi, Yapp, Donald T

“…This review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from…”
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PEG Conjugated Zein Nanoparticles for In Vivo Use by van Ballegooie, Courtney, Wretham, Nicole, Ren, Tanya, Popescu, Ioana-Mihaela, Yapp, Donald T, Bally, Marcel B

“…Zein can be utilized to form nanoscale particles for drug delivery applications. Despite the ease of synthesis, these particles often aggregate when exposed to…”
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Induction of Cytotoxicity in Pyridine Analogues of the Anti-metastatic Ru(III) Complex NAMI‑A by Ferrocene Functionalization by Mu, Changhua, Chang, Stephanie W, Prosser, Kathleen E, Leung, Ada W. Y, Santacruz, Stephanie, Jang, Thalia, Thompson, John R, Yapp, Donald T. T, Warren, Jeffrey J, Bally, Marcel B, Beischlag, Timothy V, Walsby, Charles J

“…A series of novel ferrocene (Fc) functionalized Ru­(III) complexes was synthesized and characterized. These compounds are derivatives of the anti-metastatic…”
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Gold–Protein Composite Nanoparticles for Enhanced X-ray Interactions: A Potential Formulation for Triggered Release by van Ballegooie, Courtney, Man, Alice, Pallaoro, Alessia, Bally, Marcel, Gates, Byron D., Yapp, Donald T.

“…Drug-delivery vehicles have been used extensively to modulate the biodistribution of drugs for the purpose of maximizing their therapeutic effects while…”
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RGD conjugates of the H2dedpa scaffold: synthesis, labeling and imaging with 68Ga by Boros, Eszter, Ferreira, Cara L., Yapp, Donald T.T., Gill, Rajanvir K., Price, Eric W., Adam, Michael J., Orvig, Chris

“…The rekindled interest in the 68Ga generator as an attractive positron emission tomography generator system has led us and others to investigate novel chelate…”
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The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion by Pasiliao, Clarissa C, Chang, Che-Wei A, Sutherland, Brent W, Valdez, Shannon M, Schaeffer, David, Yapp, Donald T, Ng, Sylvia S W

“…Over-expression of insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC)…”
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Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine by Verreault, Maite, Strutt, Dita, Masin, Dana, Anantha, Malathi, Yung, Andrew, Kozlowski, Piotr, Waterhouse, Dawn, Bally, Marcel B, Yapp, Donald T

“…Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor perfusion in the tumor. The present study evaluates how treatment with liposomal…”
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Synthesis, characterization, and biological studies of emissive rhenium–glutamine conjugates by Huang, Rachel, Langille, Graeme, Gill, Ravanjir K., Li, Cindy Mei Jin, Mikata, Yuji, Wong, May Q., Yapp, Donald T., Storr, Tim

“…Two new rhenium complexes containing pyridine–triazole (pyta) and quinoline–triazole (quinta) ligands with attached glutamine-targeting agents have been…”
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Characterization of cationic liposome formulations designed to exhibit extended plasma residence times and tumor vasculature targeting properties by Ho, Emmanuel A, Ramsay, Euan, Ginj, Mihaela, Anantha, Malathi, Bregman, Isaiah, Sy, Jonathan, Woo, Janet, Osooly-Talesh, Maryam, Yapp, Donald T, Bally, Marcel B

“…Cationic liposomes exhibit a propensity to selectively target tumor-associated blood vessels demonstrating potential value as anti-cancer drug delivery…”
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Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia by McDonald, Paul C., Chafe, Shawn C., Brown, Wells S., Saberi, Saeed, Swayampakula, Mridula, Venkateswaran, Geetha, Nemirovsky, Oksana, Gillespie, Jordan A., Karasinska, Joanna M., Kalloger, Steve E., Supuran, Claudiu T., Schaeffer, David F., Bashashati, Ali, Shah, Sohrab P., Topham, James T., Yapp, Donald T., Li, Jinyang, Renouf, Daniel J., Stanger, Ben Z., Dedhar, Shoukat

“…Most pancreatic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, and are refractory to chemo and radiation…”
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Evaluation of novel bifunctional chelates for the development of Cu-64-based radiopharmaceuticals by Ferreira, Cara L, Yapp, Donald T, Lamsa, Eric, Gleave, Martin, Bensimon, Corinne, Jurek, Paul, Kiefer, Garry E

“…Abstract Background Currently available bifunctional chelates (BFCs) for attaching Cu-64 to a targeting molecule are limited by either their radiolabeling…”
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Irinophore C, a Novel Nanoformulation of Irinotecan, Alters Tumor Vascular Function and Enhances the Distribution of 5-Fluorouracil and Doxorubicin by BAKER, Jennifer H. E, LAM, Jeffrey, ADAM, Michael J, YUNG, Andrew, KOZLOWSKI, Piotr, MINCHINTON, Andrew I, NG, Sylvia S. W, BALLY, Marcel B, YAPP, Donald T. T, KYLE, Alaistair H, SY, Jonathan, OLIVER, Thomas, CO, Steven J, DRAGOWSKA, Wieslawa H, RAMSAY, Euan, ANANTHA, Malathi, RUTH, Thomas J

“…Purpose: To examine the antitumor effects of Irinophore C, a nanopharmaceutical formulation of irinotecan, on the tissue morphology and function of tumor…”
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Tuning the Surface Chemistry of Second-Harmonic-Active Lithium Niobate Nanoprobes Using a Silanol–Alcohol Condensation Reaction by Ali, Rana Faryad, Guo, Iris, Kang, Henry, Radford, Melissa J, Yapp, Donald T, Gates, Byron D

“…The surface functionalization of nanoparticles (NPs) is of great interest for improving the use of NPs in, for example, therapeutic and diagnostic…”
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Decreased levels of hypoxic cells in gefitinib treated ER+ HER-2 overexpressing MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway : therapeutic implications for combination therapy with rapamycin by DRAGOWSKA, Wieslawa H, VERREAULT, Maïté, YAPP, Donald T. T, WARBURTON, Corinna, EDWARDS, Lincoln, RAMSAY, Euan C, HUXHAM, Lynsey A, MINCHINTON, Andrew I, GELMON, Karen, BALLY, Marcel B

“…Developing novel synergistic and more effective combination treatments is necessary for better management of breast cancer in the clinic. It is established…”
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Dual mode fluorescent (18)F-PET tracers: efficient modular synthesis of rhodamine-[cRGD]2-[(18)F]-organotrifluoroborate, rapid, and high yielding one-step (18)F-labeling at high specific activity, and correlated in vivo PET imaging and ex vivo fluorescence by Liu, Zhibo, Radtke, Mark Alex, Wong, May Q, Lin, Kuo-Shyan, Yapp, Donald T, Perrin, David M

“…The design of dual mode fluorescent-PET peptidic tracers that can be labeled with [(18)F]fluoride at high specific activity and high yield has been challenged…”
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Increasing the Bioavailability of RuIII Anticancer Complexes through Hydrophobic Albumin Interactions by Webb, Michael I., Wu, Boris, Jang, Thalia, Chard, Ryan A., Wong, Edwin W. Y., Wong, May Q., Yapp, Donald T. T., Walsby, Charles J.

“…A series of pyridine‐based derivatives of the clinically successful RuIII‐based complexes indazolium [trans‐RuCl4(1 H‐indazole)2] (KP1019) and sodium…”
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Irinophore C™, a lipid nanoparticulate formulation of irinotecan, improves vascular function, increases the delivery of sequentially administered 5-FU in HT-29 tumors, and controls tumor growth in patient derived xenografts of colon cancer by Neijzen, Robert, Wong, May Q., Gill, Navdeep, Wang, He, Karim, Tamanna, Anantha, Malathi, Strutt, Dita, Waterhouse, Dawn, Bally, Marcel B., Tai, Isabella T., Ng, Sylvia S.W., Yapp, Donald T.

“…A liposomal formulation of irinotecan, Irinophore C™ (IrC™) is efficacious in a panel of tumor models, normalizes tumor vasculature, and increases the…”
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Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2 by Weiswald, Louis-Bastien, Hasan, Mohammad R, Wong, John C T, Pasiliao, Clarissa C, Rahman, Mahbuba, Ren, Jianhua, Yin, Yaling, Gusscott, Samuel, Vacher, Sophie, Weng, Andrew P, Kennecke, Hagen F, Bièche, Ivan, Schaeffer, David F, Yapp, Donald T, Tai, Isabella T

“…Cyclin-dependent kinase 10 (CDK10), a CDC2-related kinase, is highly expressed in colorectal cancer. Its role in the pathogenesis of colorectal cancer is…”
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The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth by Yapp, Donald T., Wong, May Q., Kyle, Alastair H., Valdez, Shannon M., Tso, Jenny, Yung, Andrew, Kozlowski, Piotr, Owen, David A., Buczkowski, Andrzej K., Chung, Stephen W., Scudamore, Charles H., Minchinton, Andrew I., Ng, Sylvia S. W.

“…Background Metronomic chemotherapy has shown promising activity against solid tumors and is believed to act in an antiangiogenic manner. The current study…”
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