Search Results - "Yap, T."

Targeting autophagy using natural compounds for cancer prevention and therapy by Deng, Shuo, Shanmugam, Muthu K., Kumar, Alan Prem, Yap, Celestial T., Sethi, Gautam, Bishayee, Anupam

“…Autophagy, also known as macroautophagy, is a tightly regulated process involved in the stress responses, such as starvation. It is a vacuolar, lysosomal…”
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Dual role of autophagy in hallmarks of cancer by Singh, Shikha Satendra, Vats, Somya, Chia, Amelia Yi-Qian, Tan, Tuan Zea, Deng, Shuo, Ong, Mei Shan, Arfuso, Frank, Yap, Celestial T., Goh, Boon Cher, Sethi, Gautam, Huang, Ruby Yun-Ju, Shen, Han Ming, Manjithaya, Ravi, Kumar, Alan Prem

“…Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and…”
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Timing of dental extractions in patients undergoing radiotherapy and the incidence of osteoradionecrosis: a systematic review and meta-analysis by Beaumont, S., Bhatia, N., McDowell, L., Fua, T., McCullough, M., Celentano, A., Yap, T.

“…This systematic review aimed to examine whether the incidence of osteonecrosis differed between patients who have dental extractions before or after…”
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Redox regulation of cancer cell migration and invasion by Tochhawng, Lalchhandami, Deng, Shuo, Pervaiz, Shazib, Yap, Celestial T

“…Cancer cell migration and invasion are the initial steps in metastasis. Through a series of cellular events, including cytoskeletal remodeling resulting in…”
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PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy by Wang, Liming, Cho, Yik-Lam, Tang, Yancheng, Wang, Jigang, Park, Jung-Eun, Wu, Yajun, Wang, Chunxin, Tong, Yan, Chawla, Ritu, Zhang, Jianbin, Shi, Yin, Deng, Shuo, Lu, Guang, Wu, Yihua, Tan, Hayden Weng-Siong, Pawijit, Pornteera, Lim, Grace Gui-Yin, Chan, Hui-Ying, Zhang, Jingzi, Fang, Lei, Yu, Hanry, Liou, Yih-Cherng, Karthik, Mallilankaraman, Bay, Boon-Huat, Lim, Kah-Leong, Sze, Siu-Kwan, Yap, Celestial T., Shen, Han-Ming

“…Mitophagy is an important type of selective autophagy for specific elimination of damaged mitochondria. PTEN-induced putative kinase protein 1…”
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Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective by Ong, Mei Shan, Deng, Shuo, Halim, Clarissa Esmeralda, Cai, Wanpei, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Sethi, Gautam, Hooi, Shing Chuan, Kumar, Alan Prem, Yap, Celestial T

“…Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival…”
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Ultralow‐dose rituximab in pemphigus: a single‐centre experience by Simpson, K., Low, Z.M., Yap, T., Kern, J.S., Scardamaglia, L.

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Oncology phase I trial design and conduct: time for a change - MDICT Guidelines 2022 by Araujo, D., Greystoke, A., Bates, S., Bayle, A., Calvo, E., Castelo-Branco, L., de Bono, J., Drilon, A., Garralda, E., Ivy, P., Kholmanskikh, O., Melero, I., Pentheroudakis, G., Petrie, J., Plummer, R., Ponce, S., Postel-Vinay, S., Siu, L., Spreafico, A., Stathis, A., Steeghs, N., Yap, C., Yap, T.A., Ratain, M., Seymour, L.

“…In 2021, the Food and Drug Administration Oncology Center of Excellence announced Project Optimus focusing on dose optimization for oncology drugs. The…”
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Involvement of STAT5 in Oncogenesis by Halim, Clarissa Esmeralda, Deng, Shuo, Ong, Mei Shan, Yap, Celestial T.

“…Signal transducer and activator of transcription (STAT) proteins, and in particular STAT3, have been established as heavily implicated in cancer. Recently, the…”
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Drivers and consequences of land use patterns in a developing country rural community by Wagner, Adrian, Yap, David Leonides T., Yap, Helen T.

“…•Philippine forest cover decreased historically due to extensive commercial logging.•Forest cover continues to be depleted due to logging and swidden…”
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Patient selection biomarker strategies for PARP inhibitor therapy by Pilié, P.G., George, A., Yap, T.A.

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Hypertriglyceridemia-associated acute pancreatitis: Response to continuous insulin infusion by Pulipati, Vishnu Priya, Amblee, Ambika, Yap, Sara Elizabeth T, Shaka, Hafeez, Tahsin, Bettina, Fogelfeld, Leon

“…To assess the response of serum triglycerides (TG) to continuous insulin infusion (CII) in adults with hypertriglyceridemia-associated acute pancreatitis…”
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Efficacy and Safety of Regorafenib in Patients With Metastatic and/or Unresectable GI Stromal Tumor After Failure of Imatinib and Sunitinib: A Multicenter Phase II Trial by George, Suzanne, Wang, Qian, Heinrich, Michael C, Corless, Christopher L, Zhu, Meijun, Butrynski, James E, Morgan, Jeffrey A, Wagner, Andrew J, Choy, Edwin, Tap, William D, Yap, Jeffrey T, Van den Abbeele, Annick D, Manola, Judith B, Solomon, Sarah M, Fletcher, Jonathan A, von Mehren, Margaret, Demetri, George D

“…Metastatic GI stromal tumor (GIST) is a life-threatening disease with no therapy of proven efficacy after failure of imatinib and sunitinib. Regorafenib is a…”
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A rare case of an extra-oral plasmablastic lymphoma presenting through a scrotal abscess in a 42-year-old man by Śluzar, P, Reekhaye, A, MacAskill, F, Ong, M, Rose, V, Yap, T

“…Plasmablastic lymphoma (PBL) is a rare lymphoid neoplasm frequently presenting in the oral cavity. It is an aggressive type of non-Hodgkin's lymphoma that…”
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Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study by von Mehren, Margaret, George, Suzanne, Heinrich, Michael C, Schuetze, Scott M, Yap, Jeffrey T, Yu, Jain Q, Abbott, Amanda, Litwin, Samuel, Crowley, John, Belinsky, Martin, Janeway, Katherine A, Hornick, Jason L, Flieder, Douglas B, Chugh, Rashmi, Rink, Lori, Van den Abbeele, Annick D

“…Most gastrointestinal stromal tumors (GIST) have activating mutations of , or uncommonly . Fifteen percent of adult and 85% of pediatric GISTs are wild type…”
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Image analysis by Krawtchouk moments by Yap, P.-T., Paramesran, R., Seng-Huat Ong

“…A new set of orthogonal moments based on the discrete classical Krawtchouk polynomials is introduced. The Krawtchouk polynomials are scaled to ensure numerical…”
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HER2-low expression in patients with advanced or metastatic solid tumors by Uzunparmak, B., Haymaker, C., Raso, G., Masciari, S., Wang, L., Lin, H., Gorur, A., Kirby, B., Cimo, A.-M., Kennon, A., Ding, Q., Urschel, G., Yuan, Y., Feng, G., Rizvi, Y., Hussain, A., Zhu, C., Kim, P., Abbadessa, G., Subbiah, V., Yap, T.A., Rodon, J., Piha-Paul, S.A., Meric-Bernstam, F., Dumbrava, E.E.

“…Human epidermal growth factor receptor 2 (HER2)-low is a newly defined category with HER2 1+ or 2+ expression by immunohistochemistry (IHC) and lack of HER2…”
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Vocalizations of the Pekin duck (Anas platyrhynchos domesticus): how stimuli, sex, and social groups affect their vocal repertoire by Schober, J.M., Merritt, J., Ulrey, M., Yap, T.Y., Lucas, J.R., Fraley, G.S.

“…Pekin ducks are exposed to stressors such as heat stress, enteric pathogens, mycotoxins, and other environmental stressors. We know from wild bird literature…”
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Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems by Tavakol, Shima, Ashrafizadeh, Milad, Deng, Shuo, Azarian, Maryam, Abdoli, Asghar, Motavaf, Mahsa, Poormoghadam, Delaram, Khanbabaei, Hashem, Afshar, Elham Ghasemipour, Mandegary, Ali, Pardakhty, Abbas, Yap, Celestial T, Mohammadinejad, Reza, Kumar, Alan Prem

“…Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial…”
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Using deep‐belief networks to understand propensity for livelihood change in a rural coastal community to further conservation by Labao, Alfonso B., Naval, Prospero C., Yap, David Leonides T., Yap, Helen T.

“…Overharvesting of terrestrial and marine resources may be alleviated by encouraging an alternative configuration of livelihoods, particularly in rural…”
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