Search Results - "Yao, Yingjia"

Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells by Liang, Xicai, Yao, Yingjia, Lin, Ying, Kong, Liang, Xiao, Honghe, Shi, Yue, Yang, Jingxian

“…Alzheimer's disease (AD), a neurodegenerative disease, is characterized by memory loss and synaptic damage. Up to now, there are limited drugs to cure or delay…”
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The Coumarin Derivative Osthole Stimulates Adult Neural Stem Cells, Promotes Neurogenesis in the Hippocampus, and Ameliorates Cognitive Impairment in APP/PS1 Transgenic Mice by Kong, Liang, Hu, Yu, Yao, Yingjia, Jiao, Yanan, Li, Shaoheng, Yang, Jingxian

“…It is believed that neuronal death caused by abnormal deposition of amyloid-beta peptide is the major cause of the cognitive decline in Alzheimer’s disease…”
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CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer by Zhong, Chunge, Jiang, Wen-Jie, Yao, Yingjia, Li, Zexu, Li, You, Wang, Shengnan, Wang, Xiaofeng, Zhu, Wenjuan, Wu, Siqi, Wang, Jing, Fan, Shuangshuang, Ma, Shixin, Liu, Yeshu, Zhang, Han, Zhao, Wenchang, Zhao, Lu, Feng, Yi, Li, Zihan, Guo, Ruifang, Yu, Li, Pei, Fengyun, Hu, Jun, Feng, Xingzhi, Yang, Zihuan, Yang, Zhengjia, Yang, Xueying, Hou, Yue, Zhang, Danni, Xu, Dake, Sheng, Ren, Li, Yihao, Liu, Lijun, Wu, Hua-Jun, Huang, Jun, Fei, Teng

“…Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers…”
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Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury by Xia, Yang, Kong, Liang, Yao, Yingjia, Jiao, Yanan, Song, Jie, Tao, Zhenyu, You, Zhong, Yang, Jingxian

“…Neuroendoscopy is an innovative technique for neurosurgery that can nonetheless result in traumatic brain injury. The accompanying neuroinflammation may lead…”
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An in silico drug repositioning workflow for host-based antivirals by Li, Zexu, Yao, Yingjia, Cheng, Xiaolong, Li, Wei, Fei, Teng

“…Drug repositioning represents a cost- and time-efficient strategy for drug development. Artificial intelligence-based algorithms have been applied in drug…”
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A computational framework of host-based drug repositioning for broad-spectrum antivirals against RNA viruses by Li, Zexu, Yao, Yingjia, Cheng, Xiaolong, Chen, Qing, Zhao, Wenchang, Ma, Shixin, Li, Zihan, Zhou, Hu, Li, Wei, Fei, Teng

“…RNA viruses are responsible for many zoonotic diseases that post great challenges for public health. Effective therapeutics against these viral infections…”
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Kernel support vector machine classifiers with ℓ0-norm hinge loss by Lin, Rongrong, Yao, Yingjia, Liu, Yulan

“…Support vector machines (SVMs) are some of the most successful machine learning models for binary classification problems. Their key idea is maximizing the…”
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Kernel support vector machine classifiers with ℓ 0 -norm hinge loss by Lin, Rongrong, Yao, Yingjia, Liu, Yulan

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A chemical-enhanced system for CRISPR-Based nucleic acid detection by Li, Zihan, Zhao, Wenchang, Ma, Shixin, Li, Zexu, Yao, Yingjia, Fei, Teng

“…The CRISPR-based nucleic acid detection systems have shown great potential for point-of-care testing of viral pathogens, especially in the context of COVID-19…”
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Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease by Yao, Yingjia, Wang, Yameng, Kong, Liang, Chen, Yuqing, Yang, Jingxian

“…Alzheimer's disease (AD), a neurodegenerative disease, was characterized by the loss of memory and progressive cognitive deterioration. Up to now, there has no…”
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Retraction notice to “Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease” [Life Sci. 217 (2019) 16–24] by Yao, Yingjia, Wang, Yameng, Kong, Liang, Chen, Yuqing, Yang, Jingxian

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Signal Quality Assessment and Lightweight QRS Detection for Wearable ECG SmartVest System by Liu, Chengyu, Zhang, Xiangyu, Zhao, Lina, Liu, Feifei, Chen, Xingwen, Yao, Yingjia, Li, Jianqing

“…Recently, development of wearable and Internet of Things (IoT) technologies enables the real-time and continuous individual electrocardiogram (ECG) monitoring…”
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Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p by Lin, Ying, Liang, Xicai, Yao, Yingjia, Xiao, Honghe, Shi, Yue, Yang, Jingxian

“…Aim: Alzheimer's disease (AD) is a slowly progressing neurodegenerative disorder that attributed to the increase of amyloid precursor protein (APP). Recently,…”
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Retraction notice to “Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p” [Life Sci. 225 (2019) 117–131] by Lin, Ying, Liang, Xicai, Yao, Yingjia, Xiao, Honghe, Shi, Yue, Jingxian, Yang

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RETRACTED: Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease by Yao, Yingjia, Wang, Yameng, Kong, Liang, Chen, Yuqing, Yang, Jingxian

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
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Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury by Yan, Yuhui, Kong, Liang, Xia, Yang, Liang, Wenbo, Wang, Litong, Song, Jie, Yao, Yingjia, Lin, Ying, Yang, Jingxian

“…•A mouse model of stab wound injury (SWI) was successfully established to mimic the process of acute mechanical brain injury (MBI).•Osthole promoted endogenoud…”
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Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer's disease model by Yao, Yingjia, Gao, Zhong, Liang, Wenbo, Kong, Liang, Jiao, Yanan, Li, Shaoheng, Tao, Zhenyu, Yan, Yuhui, Yang, Jingxian

“…Neurogenesis is the process by which neural stem cells (NSCs) proliferate and differentiate into neurons. This is diminished in several neurodegenerative…”
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Corrigendum to “Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury” [Brain Behav. Immun. 67 (2018) 118–129] by Yan, Yuhui, Kong, Liang, Xia, Yang, Liang, Wenbo, Wang, Litong, Song, Jie, Yao, Yingjia, Lin, Ying, Yang, Jingxian

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Osthole alleviates inflammation by down-regulating NF-κB signaling pathway in traumatic brain injury by Kong, Liang, Yao, Yingjia, Xia, Yang, Liang, Xicai, Ni, Yingnan, Yang, Jingxian

“…Traumatic brain injury (TBI) is a common neurotrosis disorder of the central nervous system (CNS), which has dramatic consequences on the integrity of damaged…”
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A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism by Yao, Yingjia, Zhang, Yunhan, Li, Zexu, Chen, Zhisong, Wang, Xiaofeng, Li, Zihan, Yu, Li, Cheng, Xiaolong, Li, Wei, Jiang, Wen-Jie, Wu, Hua-Jun, Feng, Zezhong, Sun, Jinfu, Fei, Teng

“…The recent outbreak of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a severe threat to…”
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