Search Results - "Yao, Xin‐Sheng"

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis by Lv, Jian-Ming, Hu, Dan, Gao, Hao, Kushiro, Tetsuo, Awakawa, Takayoshi, Chen, Guo-Dong, Wang, Chuan-Xi, Abe, Ikuro, Yao, Xin-Sheng

“…Fusidane-type antibiotics represented by helvolic acid, fusidic acid and cephalosporin P 1 are a class of bacteriostatic agents, which have drawn renewed…”
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Biosynthesis of Biscognienyne B Involving a Cytochrome P450‐Dependent Alkynylation by Lv, Jian‐Ming, Gao, Yao‐Hui, Zhao, Huan, Awakawa, Takayoshi, Liu, Ling, Chen, Guo‐Dong, Yao, Xin‐Sheng, Hu, Dan, Abe, Ikuro, Gao, Hao

“…The alkyne is a biologically significant moiety found in many natural products and a versatile functional group widely used in modern chemistry. Recent studies…”
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Fuziline alleviates isoproterenol‐induced myocardial injury by inhibiting ROS‐triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway by Fan, Cai‐lian, Yao, Zhi‐hong, Ye, Meng‐nan, Fu, Lei‐lei, Zhu, Guo‐nian, Dai, Yi, Yao, Xin‐sheng

“…Fuziline, an aminoalcohol‐diterpenoid alkaloid derived from Aconiti lateralis radix preparata, has been reported to have a cardioprotective activity in vitro…”
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Delivering Crocetin across the Blood-Brain Barrier by Using γ-Cyclodextrin to Treat Alzheimer’s Disease by Wong, Ka Hong, Xie, Yuning, Huang, Xiao, Kadota, Kazunori, Yao, Xin-Sheng, Yu, Yang, Chen, Xiaoyu, Lu, Aiping, Yang, Zhijun

“…Crocetin (CRT) has shown various neuroprotective effects such as antioxidant activities and the inhibition of amyloid β fibril formation, and thus is a…”
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Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology by Zheng, Yan-Mei, Lin, Fu-Long, Gao, Hao, Zou, Gen, Zhang, Jiang-Wei, Wang, Gao-Qian, Chen, Guo-Dong, Zhou, Zhi-Hua, Yao, Xin-Sheng, Hu, Dan

“…Filamentous fungi represent an invaluable source of pharmaceutically active compounds. The development of versatile methods to genetically manipulate…”
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Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages by Luo, Jin-Fang, Shen, Xiu-Yu, Lio, Chon Kit, Dai, Yi, Cheng, Chun-Song, Liu, Jian-Xin, Yao, Yun-Da, Yu, Yang, Xie, Ying, Luo, Pei, Yao, Xin-Sheng, Liu, Zhong-Qiu, Zhou, Hua

“…The roots and rhizomes of have neuroprotection and cardiovascular protection effects. However, the specific mechanism of is not yet clear. Nardochinoid C (DC)…”
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Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage by Wang, Gao-Qian, Chen, Guo-Dong, Qin, Sheng-Ying, Hu, Dan, Awakawa, Takayoshi, Li, Shao-Yang, Lv, Jian-Ming, Wang, Chuan-Xi, Yao, Xin-Sheng, Abe, Ikuro, Gao, Hao

“…Furanosteroids, represented by wortmannin, viridin, and demethoxyviridin, are a special group of fungal-derived, highly oxygenated steroids featured by an…”
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Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra‐performance liquid chromatography coupled time‐of‐flight mass spectrometry by Zhang, Feng‐xiang, Li, Zi‐ting, Li, Chang, Li, Min, Yao, Zhi‐hong, Yao, Xin‐sheng, Dai, Yi

“…Objectives This study was designed to profile the chemical information of Forsythiae Fructus (FF) and investigate the in‐vivo FF‐related xenobiotics,…”
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A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process by Liu, Jing‐Yuan, Lin, Fu‐Long, Taizoumbe, Kizerbo A., Lv, Jian‐Ming, Wang, Yong‐Heng, Wang, Gao‐Qian, Chen, Guo‐Dong, Yao, Xin‐Sheng, Hu, Dan, Gao, Hao, Dickschat, Jeroen S.

“…The diterpene synthase AfAS was identified from Aspergillus fumigatiaffinis. Its amino acid sequence and—according to a structural model—active site…”
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Pharmacokinetics, hepatic disposition, and heart tissue distribution of 14 compounds in rat after oral administration of Qi‐Li‐Qiang‐Xin capsule via ultra‐high‐performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry by Tang, Xi‐Yang, Dai, Zi‐Qin, Zeng, Jia‐Xing, Li, Zi‐Ting, Fan, Cai‐Lian, Yao, Zhi‐Hong, Yao, Xin‐Sheng, Dai, Yi

“…In the present study, a specific and sensitive approach using ultra‐high‐performance liquid chromatography coupled with triple quadrupole tandem mass…”
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Discovery of the mechanisms and major bioactive compounds responsible for the protective effects of Gualou Xiebai Decoction on coronary heart disease by network pharmacology analysis by Li, Chong, Zhang, Wei-Yang, Yu, Yang, Cheng, Chun-Song, Han, Jing-Yan, Yao, Xin-Sheng, Zhou, Hua

“…Gualou Xiebai decoction (GLXB), a multi-component herbal formula, has been widely used to treat coronary heart disease (CHD) in China for centuries. Several…”
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Sporormielones A-E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin by Chen, Guo-Dong, Hu, Dan, Huang, Mei-Juan, Tang, Jia, Wang, Xiao-Xia, Zou, Jian, Xie, Jun, Zhang, Wei-Guang, Guo, Liang-Dong, Yao, Xin-Sheng, Abe, Ikuro, Gao, Hao

“…Sporormielones A-E (1-5), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of…”
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An integrated strategy by absorbed component characterization, pharmacokinetics, and activity evaluation for identification of potential nephroprotective substances in Zhu‐Ling decoction by Shu, Zhi‐heng, Fan, Cai‐lian, Wei, Hong‐yan, Li, Zi‐ting, Norimoto, Hisayoshi, Tang, Xi‐yang, Yao, Zhi‐hong, Yao, Xin‐sheng, Dai, Yi

“…An efficient strategy for the identification of potential nephroprotective substances in Zhu‐Ling decoction has been established with the integration of…”
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Biosynthetic characterization of the antifungal fernane-type triterpenoid polytolypin for generation of new analogues via combinatorial biosynthesis by Li, Xin-Yu, Lv, Jian-Ming, Cao, Zhi-Qin, Wang, Gao-Qian, Lin, Fu-Long, Chen, Guo-Dong, Qin, Sheng-Ying, Hu, Dan, Gao, Hao, Yao, Xin-Sheng

“…Fernane-type triterpenoids are a small group of natural products mainly found in plants and fungi with a wide range of biological activities. Polytolypin is a…”
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Isolation of new compounds related to xyloketals biosynthesis implies an alternative pathway for furan-fused-chromene formation by Huang, Jia-Hua, Lv, Jian-Ming, Xie, Yan-Feng, Zhao, Huan, Xiao, Liang-Yan, Dai, Ping, Qin, Sheng-Ying, Hu, Dan, Gao, Hao, Yao, Xin-Sheng

“…In fungi, there is a rare group of natural products harboring the 2,3,3a,9a-tetrahydro-4 -furo[2,3- ]chromene skeleton, represented by xyloketal B, which…”
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Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma by Hu, Qiong-Ying, Liu, Jie, Zhang, Xiao-Kun, Yang, Wan-Ting, Tao, Yu-Tian, Chen, Ce, Qian, Ye-He, Tang, Jin-Shan, Yao, Xin-Sheng, Xu, Ying-He, Wang, Jing-Hui

“…Prostate adenocarcinoma (PRAD) is the most frequent malignancy, and is the second leading cause of death due to cancer in men. Thus, new prognostic biomarkers…”
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Baphicacanthcusines A–E, Bisindole Alkaloids from the Leaves of Baphicacanthus cusia (Nees) Bremek by Zhu, Ling-Juan, Cao, Fei, Su, Xiang-Xin, Li, Chun-Yu, Lin, Bin, Wang, Hai-Feng, Yao, Xin-Sheng, Zhang, Xue, Jia, Jing-Ming, Liu, Hong-Wei

“…Four pairs of stereoisomeric indole alkaloids, (±)-baphicacanthcusines A–D (1–4), and one new indole alkaloid, baphicacanthcusine E (5), together with nine…”
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Nardochinoid B Inhibited the Activation of RAW264.7 Macrophages Stimulated by Lipopolysaccharide through Activating the Nrf2/HO-1 Pathway by Yao, Yun-Da, Shen, Xiu-Yu, Machado, Jorge, Luo, Jin-Fang, Dai, Yi, Lio, Chon-Kit, Yu, Yang, Xie, Ying, Luo, Pei, Liu, Jian-Xin, Yao, Xin-Sheng, Liu, Zhong-Qiu, Zhou, Hua

“…Nardochinoid B (NAB) is a new compound isolated from . Although our previous study reported that the NAB suppressed the production of nitric oxide (NO) in…”
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Strengthen the research on the medicinal and edible substances to advance the development of the comprehensive healthcare industry of TCMs by GAO, Hao, YAO, Xin-Sheng

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Stachybotranes A-D, phenylspirodrimanes from the wetland fungus Stachybotrys chartarum with cytotoxic activities by Bao, Yan-Ru, Feng, Han-Lin, Yao, Xin-Sheng

“…Four new phenylspirodrimanes, stachybotranes A-D (1-4), along with seven known analogues (5-11), were isolated from the extract of a wetland fungal strain…”
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