COMMD proteins function and their regulating roles in tumors

COMMD proteins function and their regulating roles in tumors

The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associat...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology Vol. 13; p. 1067234
Main Authors: You, Guangqiang, Zhou, Chen, Wang, Lei, Liu, Zefeng, Fang, He, Yao, Xiaoxao, Zhang, Xuewen
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 23-01-2023
Subjects:
cancer
COMMD
copper homeostasis
endosomal sorting
ion transport
NF-κB
Oncology
NF-κB
cancer
ion transport
endosomal sorting
COMMD
copper homeostasis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associated with a wide range of disorders, such as hepatitis, myocardial ischemia, cerebral ischemia, HIV infection, and cancer. Among these, the role of COMMD proteins in tumors has been thoroughly explored; they promote or inhibit cancers such as lung cancer, liver cancer, gastric cancer, and prostate cancer. COMMD proteins can influence tumor proliferation, invasion, metastasis, and tumor angiogenesis, which are strongly related to the prognosis of tumors and are possible therapeutic targets for treating tumors. In terms of molecular mechanism, COMMD proteins in tumor cells regulate the oncogenes of NF-κB, HIF, c-MYC, and others, and are related to signaling pathways including apoptosis, autophagy, and ferroptosis. For the clinical diagnosis and therapy of malignancies, additional research into the involvement of COMMD proteins in cancer is beneficial.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Massimo Broggini, Mario Negri Institute for Pharmacological Research (IRCCS), Italy
Reviewed by: Zixue Xuan, Hangzhou Medical College, China; Pádraig D’Arcy, Linköping University, Sweden
This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1067234