Search Results - "Yao, Lutian"

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment by Zhong, Leilei, Yao, Lutian, Tower, Robert J, Wei, Yulong, Miao, Zhen, Park, Jihwan, Shrestha, Rojesh, Wang, Luqiang, Yu, Wei, Holdreith, Nicholas, Huang, Xiaobin, Zhang, Yejia, Tong, Wei, Gong, Yanqing, Ahn, Jaimo, Susztak, Katalin, Dyment, Nathanial, Li, Mingyao, Long, Fanxin, Chen, Chider, Seale, Patrick, Qin, Ling

“…Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in bone homeostasis and diseases such as osteoporosis. While it is long…”
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SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation by Hasee, Abdul, Kc, Ranjan, Angelozzi, Marco, de Charleroy, Charles, Rux, Danielle, Tower, Robert J., Yao, Lutian, da Silva, Renata Pellegrino, Pacifici, Maurizio, Qin, Ling, Lefebvre, Véronique

“…Cartilage is essential throughout vertebrate life. It starts developing in embryos when osteochondroprogenitor cells commit to chondrogenesis, activate a…”
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Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic male mice by Song, Fangfang, Lee, Won Dong, Marmo, Tyler, Ji, Xing, Song, Chao, Liao, Xueyang, Seeley, Rebecca, Yao, Lutian, Liu, Haoran, Long, Fanxin

“…Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism is not well understood. Here, in a mouse model for…”
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Targeting cartilage EGFR pathway for osteoarthritis treatment by Wei, Yulong, Luo, Lijun, Gui, Tao, Yu, Feifan, Yan, Lesan, Yao, Lutian, Zhong, Leilei, Yu, Wei, Han, Biao, Patel, Jay M, Liu, Jessica F, Beier, Frank, Levin, Lawrence Scott, Nelson, Charles, Shao, Zengwu, Han, Lin, Mauck, Robert L, Tsourkas, Andrew, Ahn, Jaimo, Cheng, Zhiliang, Qin, Ling

“…Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying treatments. Previously, we found that mice with cartilage-specific…”
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Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice by Mundy, Christina, Yao, Lutian, Sinha, Sayantani, Chung, Juliet, Rux, Danielle, Catheline, Sarah E, Koyama, Eiki, Qin, Ling, Pacifici, Maurizio

“…Heterotopic ossification (HO) is a common, potentially debilitating pathology that is instigated by inflammation caused by tissue damage or other insults,…”
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Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy by Yao, Lutian, Lu, Jiawei, Zhong, Leilei, Wei, Yulong, Gui, Tao, Wang, Luqiang, Ahn, Jaimo, Boerckel, Joel D, Rux, Danielle, Mundy, Christina, Qin, Ling, Pacifici, Maurizio

“…Insufficient bone fracture repair represents a major clinical and societal burden and novel strategies are needed to address it. Our data reveal that the TGF-β…”
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Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated by Zhang, Yejia, Tian, Zuozhen, Gerard, David, Yao, Lutian, Shofer, Frances S., Cs-Szabo, Gabriella, Qin, Ling, Pacifici, Maurizio, Enomoto-Iwamoto, Motomi

“…We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a…”
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EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression by Wei, Yulong, Ma, Xiaoyuan, Sun, Hao, Gui, Tao, Li, Jun, Yao, Lutian, Zhong, Leilei, Yu, Wei, Han, Biao, Nelson, Charles L., Han, Lin, Beier, Frank, Enomoto‐Iwamoto, Motomi, Ahn, Jaimo, Qin, Ling

“…ABSTRACT The uppermost superficial zone of articular cartilage is the first line of defense against the initiation of osteoarthritis (OA). We previously used…”
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The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair by Wei, Yulong, Sun, Hao, Gui, Tao, Yao, Lutian, Zhong, Leilei, Yu, Wei, Heo, Su-Jin, Han, Lin, Dyment, Nathaniel A, Liu, Xiaowei Sherry, Zhang, Yejia, Koyama, Eiki, Long, Fanxin, Zgonis, Miltiadis H, Mauck, Robert L, Ahn, Jaimo, Qin, Ling

“…Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that…”
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Interleukin-27 inhibits malignant behaviors of pancreatic cancer cells by targeting M2 polarized tumor associated macrophages by Yao, Lutian, Wang, Mengyi, Niu, Zheyu, Liu, Qiaofei, Gao, Xiang, Zhou, Li, Liao, Quan, Zhao, Yupei

“…[Display omitted] •M2 polarized TAMs expressed higher level of WSX-1.•IL-27 could invert the polarization of M2 phenotype TAMs.•IL-27 inhibited malignant…”
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Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone by Zhong, Leilei, Lu, Jiawei, Fang, Jiankang, Yao, Lutian, Yu, Wei, Gui, Tao, Duffy, Michael, Holdreith, Nicholas, Bautista, Catherine A, Huang, Xiaobin, Bandyopadhyay, Shovik, Tan, Kai, Chen, Chider, Choi, Yongwon, Jiang, Jean X, Yang, Shuying, Tong, Wei, Dyment, Nathanial, Qin, Ling

“…Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive…”
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Increased levels of interleukin-33 associated with bone erosion and interstitial lung diseases in patients with rheumatoid arthritis by Xiangyang, Zhu, Lutian, Yao, Lin, Zhao, Liping, Xia, Hui, Shen, Jing, Lu

“…► Serum IL-33 was significantly higher in RA patients than in healthy controls. ► Higher levels of IL-33 were found in CCP+ group and in patients with ILD. ►…”
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Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis by Zhang, Hui, Li, Yuxuan, Yuan, Lin, Yao, Lutian, Yang, Jie, Xia, Liping, Shen, Hui, Lu, Jing

“…Osteoporosis is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the suppressive role of…”
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Palovarotene Action Against Heterotopic Ossification Includes a Reduction of Local Participating Activin A‐Expressing Cell Populations by Mundy, Christina, Yao, Lutian, Shaughnessy, Kelly A., Saunders, Cheri, Shore, Eileen M., Koyama, Eiki, Pacifici, Maurizio

“…ABSTRACT Heterotopic ossification (HO) consists of extraskeletal bone formation. One form of HO is acquired and instigated by traumas or surgery, and another…”
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Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis by Lu, Jing, Xia, Liping, JishengWu, Siyan, Liu, Siyan, Yao, Lutian, Li, Yuxuan, Shen, Hui

“…Objective. IL-35 was reported as a crucial anti-inflammatory cytokine and could efficiently regulate bone metabolism in murine collagen-induced arthritis…”
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ADAM8 inactivation retards intervertebral disc degeneration in mice by Tian, Zuozhen, Shofer, Frances S., Fan, Mingyue, Sandroni, Alec Z., Yao, Lutian, Han, Lin, Qin, Ling, Enomoto-Iwamoto, Motomi, Zhang, Yejia

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Clinical Implications of the Interleukin 27 Serum Level in Breast Cancer by Lu, Dapeng, Zhou, Xiangyu, Yao, Lutian, Liu, Caigang, Jin, Feng, Wu, Yunfei

“…IntroductionInterleukin 27 (IL-27), belonging to the IL-12 family, exerts a critical role in immune regulation of infection, autoimmunity, and tumor. In this…”
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Targeting YAP1‐regulated Glycolysis in Fibroblast‐Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression by Yang, Jie, Li, Shanshan, Li, Zhenyan, Yao, Lutian, Liu, Meijing, Tong, Kui‐Leung, Xu, Qiutong, Yu, Bo, Peng, Rui, Gui, Tao, Tang, Wang, Xu, Yidi, Chen, Jiaxu, He, Jun, Zhao, Kewei, Wang, Xiaogang, Wang, Xiaoying, Zha, Zhengang, Zhang, Huan‐Tian

“…The interplay between immune cells/macrophages and fibroblast‐like synoviocytes (FLSs) plays a pivotal role in initiating synovitis; however, their involvement…”
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Interleukin-35 attenuates collagen-induced arthritis through suppression of vascular endothelial growth factor and its receptors by Wu, Suqin, Li, Yunxia, Li, Yuxuan, Yao, Lutian, Lin, Tiantian, Jiang, Shenyi, Shen, Hui, Xia, Liping, Lu, Jing

“…To investigate the effect of interleukin-35 (IL-35) on vascular endothelial growth factor (VEGF) and its receptors, Flt-1 and Flk-1, in a collagen-induced…”
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Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation by Zhong, Leilei, Yao, Lutian, Holdreith, Nicholas, Yu, Wei, Gui, Tao, Miao, Zhen, Elkaim, Yehuda, Li, Mingyao, Gong, Yanqing, Pacifici, Maurizio, Maity, Amit, Busch, Theresa M, Joeng, Kyu Sang, Cengel, Keith, Seale, Patrick, Tong, Wei, Qin, Ling

“…Radiation causes a collapse of bone marrow cells and elimination of microvasculature. To understand how bone marrow recovers after radiation, we focused on…”
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