Search Results - "Yao, Longbiao"

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling by Yago, Tadayuki, Shao, Bojing, Miner, Jonathan J., Yao, Longbiao, Klopocki, Arkadiusz G., Maeda, Kenichiro, Coggeshall, K. Mark, McEver, Rodger P.

“…In inflamed venules, neutrophils rolling on E-selectin induce integrin αLβ2-dependent slow rolling on intercellular adhesion molecule-1 by activating Src…”
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Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome by Shao, Bojing, Wahrenbrock, Mark G., Yao, Longbiao, David, Tovo, Coughlin, Shaun R., Xia, Lijun, Varki, Ajit, McEver, Rodger P.

“…Trousseau syndrome is classically defined as migratory, heparin-sensitive but warfarin-resistant microthrombi in patients with occult, mucinous…”
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L-selectin mechanochemistry restricts neutrophil priming in vivo by Liu, Zhenghui, Yago, Tadayuki, Zhang, Nan, Panicker, Sumith R., Wang, Ying, Yao, Longbiao, Mehta-D’souza, Padmaja, Xia, Lijun, Zhu, Cheng, McEver, Rodger P.

“…Circulating neutrophils must avoid premature activation to prevent tissue injury. The leukocyte adhesion receptor L-selectin forms bonds with P-selectin…”
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Differential regulation of human and murine P-selectin expression and function in vivo by Liu, Zhenghui, Miner, Jonathan J, Yago, Tadayuki, Yao, Longbiao, Lupu, Florea, Xia, Lijun, McEver, Rodger P

“…Leukocytes roll on P-selectin after its mobilization from secretory granules to the surfaces of platelets and endothelial cells. Tumor necrosis factor (TNF),…”
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Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease by Chen, Yitong, Heuser-Baker, Janet, Herlea-Pana, Oana, Yao, Longbiao, Barlic-Dicen, Jana

“…The escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy…”
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Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice by Yao, Longbiao, Yago, Tadayuki, Shao, Bojing, Liu, Zhenghui, Silasi-Mansat, Robert, Setiadi, Hendra, Lupu, Florea, McEver, Rodger P.

“…Neutrophils emigrate from venules to sites of infection or injury in response to chemotactic gradients. How these gradients form is not well understood. Some…”
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Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet‐induced obesity by Yao, Longbiao, Heuser‐Baker, Janet, Herlea‐Pana, Oana, Zhang, Nan, Szweda, Luke I., Griffin, Timothy M., Barlic‐Dicen, Jana

“…The chemokine receptor CXCR4 is expressed on adipocytes and macrophages in adipose tissue, but its role in this tissue remains unknown. We evaluated whether…”
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Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells by Yao, Longbiao, Yokota, Takafumi, Xia, Lijun, Kincade, Paul W., McEver, Rodger P.

“…In vitro studies suggest that bone marrow endothelial cells contribute to multilineage hematopoiesis, but this function has not been studied in vivo. We used a…”
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Divergent Inducible Expression of P-Selectin and E-Selectin in Mice and Primates by Yao, Longbiao, Setiadi, Hendra, Xia, Lijun, Laszik, Zoltan, Taylor, Fletcher B., McEver, Rodger P.

“…We used in vitro and in vivo approaches to examine whether tumor necrosis factor- (TNF-) and oncostatin M (OSM), cytokines that bind to distinct classes of…”
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Divergent Inducible Expression of P-Selectin and E-Selectin in Mice and Primates by Yao, Longbiao, Setiadi, Hendra, Xia, Lijun, Laszik, Zoltan, Taylor, Fletcher B., McEver, Rodger P.

“…We used in vitro and in vivo approaches to examine whether tumor necrosis factor-α (TNF-α) and oncostatin M (OSM), cytokines that bind to distinct classes of…”
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PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity by Iwayama, Tomoaki, Steele, Cameron, Yao, Longbiao, Dozmorov, Mikhail G, Karamichos, Dimitris, Wren, Jonathan D, Olson, Lorin E

“…Fibrosis is a common disease process in which profibrotic cells disturb organ function by secreting disorganized extracellular matrix (ECM). Adipose tissue…”
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Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis by Sun, Chengyi, Sakashita, Hiromi, Kim, Jang, Tang, Zifeng, Upchurch, G. Michael, Yao, Longbiao, Berry, William L., Griffin, Timothy M., Olson, Lorin E.

“…Adipocyte progenitors (APs) express platelet-derived growth factor receptors (PDGFRs), PDGFRα and PDGFRβ. Elevated PDGFRα signaling inhibits adipogenesis and…”
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Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing by Yao, Longbiao, Rathnakar, Bharath H., Kwon, Hae Ryong, Sakashita, Hiromi, Kim, Jang H., Rackley, Alex, Tomasek, James J., Berry, William L., Olson, Lorin E.

“…Fibroblasts differentiate into myofibroblasts by acquiring new contractile function. This is important for tissue repair, but it also contributes to organ…”
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Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice by Shi, Huiping, Song, Jianhua, Gao, Liang, Shan, Xindi, Panicker, Sumith R, Yao, Longbiao, McDaniel, Michael, Zhou, Meixiang, McGee, Samuel, Zhong, Hui, Griffin, Courtney T, Xia, Lijun, Shao, Bojing

“…Integrin-regulated monocyte recruitment and cellular responses of monocyte-derived macrophages are critical for the pathogenesis of atherosclerosis. In the…”
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P-Selectin Expressed by a Human SELP Transgene Is Atherogenic in Apolipoprotein E–Deficient Mice by Zhang, Nan, Liu, Zhenghui, Yao, Longbiao, Mehta-D’souza, Padmaja, McEver, Rodger P

“…OBJECTIVE—During inflammation, P-selectin expressed on activated endothelial cells and platelets mediates rolling adhesion of leukocytes. Atherosclerosis-prone…”
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STAT1 modulates tissue wasting or overgrowth downstream from PDGFRβ by He, Chaoyong, Medley, Shayna C, Kim, Jang, Sun, Chengyi, Kwon, Hae Ryong, Sakashita, Hiromi, Pincu, Yair, Yao, Longbiao, Eppard, Danielle, Dai, Bojie, Berry, William L, Griffin, Timothy M, Olson, Lorin E

“…Platelet-derived growth factor (PDGF) acts through two conserved receptor tyrosine kinases: PDGFRα and PDGFRβ. Gain-of-function mutations in human have been…”
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Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression by Herlea-Pana, Oana, Yao, Longbiao, Heuser-Baker, Janet, Wang, Qiongxin, Wang, Qilong, Georgescu, Constantin, Zou, Ming-Hui, Barlic-Dicen, Jana

“…Atherosclerosis manifests itself as arterial plaques, which lead to heart attacks or stroke. Treatments supporting plaque regression are therefore aggressively…”
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Bone Marrow Endothelial Progenitors Augment Atherosclerotic Plaque Regression in a Mouse Model of Plasma Lipid Lowering by Yao, Longbiao, Heuser-Baker, Janet, Herlea-Pana, Oana, Iida, Ryuji, Wang, Qilong, Zou, Ming-Hui, Barlic-Dicen, Jana

“…The major event initiating atherosclerosis is hypercholesterolemia‐induced disruption of vascular endothelium integrity. In settings of endothelial damage,…”
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A proteasome inhibitor, an antioxidant, or a salicylate, but not a glucocorticoid, blocks constitutive and cytokine-inducible expression of P-selectin in human endothelial cells by LIJUN XIA, JUNLIANG PAN, LONGBIAO YAO, MCEVER, R. P

“…Proteasome inhibitors, antioxidants, salicylates, or glucocorticoids block the cytokine-induced expression of the endothelial cell adhesion molecules…”
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Bone marrow endothelial progenitors in atherosclerotic plaque resolution by Yao, Longbiao, Heuser-Baker, Janet, Herlea-Pana, Oana, Barlic-Dicen, Jana

“…Atherosclerosis is a major cause of morbidity and mortality in the United States. Persistently elevated circulating low-density lipoprotein, or…”
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