Search Results - "Yao, Jiangwei"

Bacterial fatty acid metabolism in modern antibiotic discovery by Yao, Jiangwei, Rock, Charles O.

“…Bacterial fatty acid synthesis is essential for many pathogens and different from the mammalian counterpart. These features make bacterial fatty acid synthesis…”
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How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics by Yao, Jiangwei, Rock, Charles O.

“…Bacterial type II fatty acid synthesis (FASII) is a target for the development of novel therapeutics. Bacteria incorporate extracellular fatty acids into…”
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Human pantothenate kinase 4 is a pseudo‐pantothenate kinase by Yao, Jiangwei, Subramanian, Chitra, Rock, Charles O., Jackowski, Suzanne

“…Pantothenate kinase generates 4′‐phosphopantothenate in the first and rate‐determining step of coenzyme A (CoA) biosynthesis. The human genome encodes three…”
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Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains by Honce, Rebekah, Karlsson, Erik A, Wohlgemuth, Nicholas, Estrada, Leonardo D, Meliopoulos, Victoria A, Yao, Jiangwei, Schultz-Cherry, Stacey

“…Obesity is associated with increased disease severity, elevated viral titers in exhaled breath, and significantly prolonged viral shed during influenza A virus…”
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Characterizing a Murine Model for Astrovirus Using Viral Isolates from Persistently Infected Immunocompromised Mice by Cortez, Valerie, Sharp, Bridgett, Yao, Jiangwei, Livingston, Brandi, Vogel, Peter, Schultz-Cherry, Stacey

“…Human astroviruses are single-stranded RNA enteric viruses that cause a spectrum of disease ranging from asymptomatic infection to systemic…”
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Membrane Disruption by Antimicrobial Fatty Acids Releases Low-Molecular-Weight Proteins from Staphylococcus aureus by Parsons, Joshua B, Yao, Jiangwei, Frank, Matthew W, Jackson, Pamela, Rock, Charles O

“…The skin represents an important barrier for pathogens and is known to produce fatty acids that are toxic toward Gram-positive bacteria. A screen of fatty…”
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Review on the progress of the first-generation biodiesel hydrogenation and upgrading by Weidong, Zhao, Jiangwei, Yao, Xiaoyin, Zhang, Xiaolong, Qi

“…This paper reviewed the research status of biodiesel catalytic hydrogenation and electric field enhanced treatment of biofuels in recent years. The…”
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A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer by Robertson, Rosanna M, Yao, Jiangwei, Gajewski, Stefan, Kumar, Gyanendra, Martin, Erik W, Rock, Charles O, White, Stephen W

“…The crystal structure of Thermotoga maritima lysophosphatidic acid acyltransferase reveals a two-helix motif that positions the active site for catalysis…”
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Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis by Yao, Jiangwei, Cherian, Philip T., Frank, Matthew W., Rock, Charles O.

“…The obligate intracellular parasite Chlamydia trachomatis has a reduced genome and is thought to rely on its mammalian host cell for nutrients. Although…”
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Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis by Yao, Jiangwei, Rock, Charles O

“…is an obligate intracellular pathogen with a reduced genome reflecting its host cell dependent life style. However, has retained all of the genes required for…”
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Host Fatty Acid Utilization by Staphylococcus aureus at the Infection Site by Frank, Matthew W, Yao, Jiangwei, Batte, Justin L, Gullett, Jessica M, Subramanian, Chitra, Rosch, Jason W, Rock, Charles O

“…utilizes the fatty acid (FA) kinase system to activate exogenous FAs for membrane synthesis. We developed a lipidomics workflow to determine the membrane…”
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Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile by Bravo-Vasquez, Nicolas, Yao, Jiangwei, Jimenez-Bluhm, Pedro, Meliopoulos, Victoria, Freiden, Pamela, Sharp, Bridgett, Estrada, Leonardo, Davis, Amy, Cherry, Sean, Livingston, Brandi, Danner, Angela, Schultz-Cherry, Stacey, Hamilton-West, Christopher

“…Since their discovery in the United States in 1963, outbreaks of infection with equine influenza virus (H3N8) have been associated with serious respiratory…”
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Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus by Párraga Solórzano, Paola K, Yao, Jiangwei, Rock, Charles O, Kehl-Fie, Thomas E

“…During infection, bacteria use two-component signal transduction systems to sense and adapt to the dynamic host environment. Despite critically contributing to…”
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Tensile strength and its variation of PAN-based carbon fibers. III. Weak-link analysis by Yao, Jiangwei, Yu, Weidong, Pan, Ding

“…Both the strength and its variance of carbon fibers depend on the worst flaw that exists in the fiber, or more exactly speaking, on the structure of the "fiber…”
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Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria by Cherian, Philip T., Yao, Jiangwei, Leonardi, Roberta, Maddox, Marcus M., Luna, Vicki A., Rock, Charles O., Lee, Richard E.

“…A series of non-metabolizable, acyl-sulfamate analogs of the acyl-phosphate PlsY substrate were prepared and evaluated as inhibitors of Staphylococcus aureus…”
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Tensile strength and its variation of PAN-based carbon fibers. I. Statistical distribution and volume dependence by Yu, Weidong, Yao, Jiangwei

“…The effects of the diameter, gauge length, and volume of carbon fibers on the tensile properties and their variation are discussed on the basis of the…”
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Tensile strength and its variation for PAN-based carbon fibers. II. Calibration of the variation from testing by Yao, Jiangwei, Yu, Weidong

“…The tensile behavior of carbon fibers shows large scattering. This is due to the fiber itself and the testing operations. Because of the high tenacity and…”
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Selective Inhibitors of Bacterial Phosphopantothenoylcysteine Synthetase by Patrone, James D, Yao, Jiangwei, Scott, Nicole E, Dotson, Garry D

“…Bacterial phosphopantothenolycysteine synthetase (PPCS) catalyzes the formation of phosphopantothenoylcysteine (PPC) from (R)-phosphopantothenate, l-cysteine,…”
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Characterization and Kinetics of Phosphopantothenoylcysteine Synthetase from Enterococcus faecalis by Yao, Jiangwei, Patrone, James D, Dotson, Garry D

“…The enzyme phosphopantothenoylcysteine synthetase (PPCS) catalyzes the nucleotide-dependent formation of phosphopantothenoylcysteine from…”
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Exogenous fatty acid metabolism in bacteria by Yao, Jiangwei, Rock, Charles O.

“…Bacterial type II fatty acid synthesis (FASII) is a target for novel antibiotic development. All bacteria encode for mechanisms to incorporate exogenous fatty…”
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