Search Results - "Yao, Guangxin"
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Identification, characterization and expression analysis of rLcn13 , an epididymal lipocalin in rats
Published in Acta biochimica et biophysica Sinica (01-02-2023)“…As the essential tissue for sperm maturation and storage, the epididymis secretes a number of tissue-specific proteins to exert its functions. Among these…”
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Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome
Published in EBioMedicine (01-02-2020)“…The ovulatory dysfunction mechanisms underlying polycystic ovary syndrome (PCOS) are not completely understood. There is no effective therapy for PCOS so far…”
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A Novel Molecule in Human Cyclic Endometrium: LncRNA TUNAR Is Involved in Embryo Implantation
Published in Frontiers in physiology (19-11-2020)“…Embryo implantation rate remains an inefficient process in fertilization and embryo transfer (IVF-ET) cycles. The role long non-coding RNA (lncRNA) plays in…”
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Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway
Published in Frontiers in endocrinology (Lausanne) (30-08-2023)“…Chronic stress is suspected to be a causal factor of female subfertility; however, the underlying mechanisms remain unclear. Here, we found that chronic stress…”
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ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS
Published in Frontiers in endocrinology (Lausanne) (15-11-2018)“…Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role…”
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Novel mutations in PLCZ1 lead to early embryonic arrest as a male factor
Published in Frontiers in cell and developmental biology (16-05-2023)“…Early embryonic arrest is one of the causes of assist reproduction technology (ART) failure. We have previously reported that the first sperm-derived genetic…”
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Deficiency of Sirtuin 1 Impedes Endometrial Decidualization in Recurrent Implantation Failure Patients
Published in Frontiers in cell and developmental biology (28-01-2021)“…Decidualization is driven by differentiation of human endometrial stromal cells (ESCs), and is a prerequisite for successful implantation and establishment of…”
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Lcn5 Promoter Directs the Region-Specific Expression of Cre Recombinase in Caput Epididymidis of Transgenic Mice
Published in Biology of reproduction (01-03-2013)“…Epididymis plays a crucial role in regulating the development of sperm motility and fertilizing capacity. To study the function of genes in the caput…”
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Self-Assembly of [3]Catenane and [4]Catenane Based on Neutral Organometallic Scaffolds
Published in Frontiers in chemistry (13-12-2021)“…Transition metal-mediated templating and self-assembly have shown great potential to construct mechanically interlocked molecules. Herein, we describe the…”
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Androgen receptor binding sites identified in mouse testis
Published in Acta biochimica et biophysica Sinica (01-09-2013)“…Androgen/androgen receptor (AR) signaling plays decisive roles in testicular spermatogenesis [ 1 ]. However, the under- lying molecular mechanism of androgen…”
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Transcriptomic Changes During the Pre-Receptive to Receptive Transition in Human Endometrium Detected by RNA-Seq
Published in The journal of clinical endocrinology and metabolism (01-12-2014)“…Context: Identifying novel molecular markers for assessing endometrial receptivity is necessary for understanding human implantation and may help in improving…”
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Identification of HOXA10 target genes in human endometrial stromal cells by RNA-seq analysis
Published in Acta biochimica et biophysica Sinica (02-03-2021)“…Abstract Homeobox A10 (HOXA10) is a transcription factor belonging to the homeobox gene family. It is highly expressed in endometrial stromal cells (ESCs) and…”
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Local glucose elevation activates pyroptosis via NLRP3 inflammasome in ovarian granulosa cells of overweight patients
Published in The FASEB journal (01-03-2023)“…Overweight, with an increasing prevalence worldwide, significantly impairs the clinical outcomes following in vitro fertilization (IVF). Hyperglycemia,…”
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iTRAQ-based Proteomic Analysis Unveils ACSL4 as a Novel Potential Regulator of Human Endometrial Receptivity
Published in Endocrinology (Philadelphia) (01-03-2023)“…Abstract Competent endometrial receptivity is a prerequisite for successful embryo implantation. Identification of novel key molecules involved in endometrial…”
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Homozygous missense variations of APC12 cause meiotic metaphase I arrest in oocytes and female infertility
Published in American journal of obstetrics and gynecology (12-11-2024)“…Oocyte maturation arrest is a leading cause of female infertility. However, the genetic variables remain largely unknown. In oocytes, the activation of…”
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Identification, characterization and expression analysis of rLcn13, an epididymal lipocalin in rats: Characterization of epididymal-specific lipicalin
Published in Acta biochimica et biophysica Sinica (09-02-2023)“…As the essential tissue for sperm maturation and storage, the epididymis secretes a number of tissue-specific proteins to exert its functions. Among these…”
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The expression changes of circular RNAs between LH + 2 and LH + 7 human endometrium
Published in Acta biochimica et biophysica Sinica (13-12-2019)Get full text
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Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model
Published in Metabolism, clinical and experimental (01-06-2021)“…Polycystic ovary syndrome (PCOS) is the most common metabolic and endocrine disorder among reproductive-age women, and the leading cause of anovulatory…”
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Expression of tamoxifen‐inducible CRE recombinase in Lcn5‐CreERT2 transgenic mouse caput epididymis
Published in Molecular reproduction and development (01-03-2017)“…SUMMARY The epididymis, which connects the testis to vas deferens, plays a crucial role regulating sperm maturation and fertilization. Here, a…”
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Expression of tamoxifen-inducible CRE recombinase in Lcn5-CreER T2 transgenic mouse caput epididymis
Published in Molecular reproduction and development (01-03-2017)“…The epididymis, which connects the testis to vas deferens, plays a crucial role regulating sperm maturation and fertilization. Here, a tamoxifen-inducible…”
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