Search Results - "Yao, Cindy Q."

Molecular landmarks of tumor hypoxia across cancer types by Bhandari, Vinayak, Hoey, Christianne, Liu, Lydia Y., Lalonde, Emilie, Ray, Jessica, Livingstone, Julie, Lesurf, Robert, Shiah, Yu-Jia, Vujcic, Tina, Huang, Xiaoyong, Espiritu, Shadrielle M. G., Heisler, Lawrence E., Yousif, Fouad, Huang, Vincent, Yamaguchi, Takafumi N., Yao, Cindy Q., Sabelnykova, Veronica Y., Fraser, Michael, Chua, Melvin L. K., van der Kwast, Theodorus, Liu, Stanley K., Boutros, Paul C., Bristow, Robert G.

“…Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia. Hypoxic tumors are at elevated risk for local failure and distant…”
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Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19 by Hua, Junjie Tony, Ahmed, Musaddeque, Guo, Haiyang, Zhang, Yuzhe, Chen, Sujun, Soares, Fraser, Lu, Jennifer, Zhou, Stanley, Wang, Miranda, Li, Hui, Larson, Nicholas B., McDonnell, Shannon K., Patel, Parasvi S., Liang, Yi, Yao, Cindy Q., van der Kwast, Theodorus, Lupien, Mathieu, Feng, Felix Y., Zoubeidi, Amina, Tsao, Ming-Sound, Thibodeau, Stephen N., Boutros, Paul C., He, Housheng Hansen

“…The prostate cancer (PCa) risk-associated SNP rs11672691 is positively associated with aggressive disease at diagnosis. We showed that rs11672691 maps to the…”
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The Proteogenomic Landscape of Curable Prostate Cancer by Sinha, Ankit, Huang, Vincent, Livingstone, Julie, Wang, Jenny, Fox, Natalie S., Kurganovs, Natalie, Ignatchenko, Vladimir, Fritsch, Katharina, Donmez, Nilgun, Heisler, Lawrence E., Shiah, Yu-Jia, Yao, Cindy Q., Alfaro, Javier A., Volik, Stas, Lapuk, Anna, Fraser, Michael, Kron, Ken, Murison, Alex, Lupien, Mathieu, Sahinalp, Cenk, Collins, Colin C., Tetu, Bernard, Masoomian, Mehdi, Berman, David M., van der Kwast, Theodorus, Bristow, Robert G., Kislinger, Thomas, Boutros, Paul C.

“…DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate cancers. Surprisingly, the influence of genomic, epigenomic, and…”
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Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer by Kim, Yunee, Jeon, Jouhyun, Mejia, Salvador, Yao, Cindy Q, Ignatchenko, Vladimir, Nyalwidhe, Julius O, Gramolini, Anthony O, Lance, Raymond S, Troyer, Dean A, Drake, Richard R, Boutros, Paul C, Semmes, O. John, Kislinger, Thomas

“…Biomarkers are rapidly gaining importance in personalized medicine. Although numerous molecular signatures have been developed over the past decade, there is a…”
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BPG: Seamless, automated and interactive visualization of scientific data by P'ng, Christine, Green, Jeffrey, Chong, Lauren C, Waggott, Daryl, Prokopec, Stephenie D, Shamsi, Mehrdad, Nguyen, Francis, Mak, Denise Y F, Lam, Felix, Albuquerque, Marco A, Wu, Ying, Jung, Esther H, Starmans, Maud H W, Chan-Seng-Yue, Michelle A, Yao, Cindy Q, Liang, Bianca, Lalonde, Emilie, Haider, Syed, Simone, Nicole A, Sendorek, Dorota, Chu, Kenneth C, Moon, Nathalie C, Fox, Natalie S, Grzadkowski, Michal R, Harding, Nicholas J, Fung, Clement, Murdoch, Amanda R, Houlahan, Kathleen E, Wang, Jianxin, Garcia, David R, de Borja, Richard, Sun, Ren X, Lin, Xihui, Chen, Gregory M, Lu, Aileen, Shiah, Yu-Jia, Zia, Amin, Kearns, Ryan, Boutros, Paul C

“…We introduce BPG, a framework for generating publication-quality, highly-customizable plots in the R statistical environment. This open-source package includes…”
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2,3,7,8-Tetrachlorodibenzo-p-dioxin modifies alternative splicing in mouse liver by Villaseñor-Altamirano, Ana B, Watson, John D, Prokopec, Stephenie D, Yao, Cindy Q, Boutros, Paul C, Pohjanvirta, Raimo, Valdés-Flores, Jesús, Elizondo, Guillermo

“…Alternative splicing is a co-transcriptional mechanism that generates protein diversity by including or excluding exons in different combinations, thereby…”
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Computational approaches to support comparative analysis of multiparametric tests: Modelling versus Training by Bartlett, John M. S., Bayani, Jane, Kornaga, Elizabeth N., Danaher, Patrick, Crozier, Cheryl, Piper, Tammy, Yao, Cindy Q., Dunn, Janet A., Boutros, Paul C., Stein, Robert C.

“…Multiparametric assays for risk stratification are widely used in the management of breast cancer, with applications being developed for a number of other…”
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Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer by Chong, Taryne, Sarac, Amila, Yao, Cindy Q, Liao, Linda, Lyttle, Nicola, Boutros, Paul C, Bartlett, John M S, Spears, Melanie

“…Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late…”
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Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER by van den Beucken, Twan, Koch, Elizabeth, Chu, Kenneth, Rupaimoole, Rajesha, Prickaerts, Peggy, Adriaens, Michiel, Voncken, Jan Willem, Harris, Adrian L., Buffa, Francesca M., Haider, Syed, Starmans, Maud H. W., Yao, Cindy Q., Ivan, Mircea, Ivan, Cristina, Pecot, Chad V., Boutros, Paul C., Sood, Anil K., Koritzinsky, Marianne, Wouters, Bradly G.

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Comparative survival analysis of multiparametric tests—when molecular tests disagree—A TEAM Pathology study by Bartlett, John M. S., Bayani, Jane, Kornaga, Elizabeth, Xu, Keying, Pond, Greg R., Piper, Tammy, Mallon, Elizabeth, Yao, Cindy Q., Boutros, Paul C., Hasenburg, Annette, Dunn, J. A., Markopoulos, Christos, Dirix, Luc, Seynaeve, Caroline, van de Velde, Cornelis J. H., Stein, Robert C., Rea, Daniel

“…Multiparametric assays for risk stratification are widely used in the management of both node negative and node positive hormone receptor positive invasive…”
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Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer by Guo, Haiyang, Ahmed, Musaddeque, Zhang, Fan, Yao, Cindy Q, Li, SiDe, Liang, Yi, Hua, Junjie, Soares, Fraser, Sun, Yifei, Langstein, Jens, Li, Yuchen, Poon, Christine, Bailey, Swneke D, Desai, Kinjal, Fei, Teng, Li, Qiyuan, Sendorek, Dorota H, Fraser, Michael, Prensner, John R, Pugh, Trevor J, Pomerantz, Mark, Bristow, Robert G, Lupien, Mathieu, Feng, Felix Y, Boutros, Paul C, Freedman, Matthew L, Walsh, Martin J, He, Housheng Hansen

“…Housheng Hansen He and colleagues perform an integrated analysis and identify 45 candidate long noncoding RNAs (lncRNAs) associated with prostate cancer risk…”
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Molecular stratification of early breast cancer identifies drug targets to drive stratified medicine by Bayani, Jane, Yao, Cindy Q., Quintayo, Mary Anne, Yan, Fu, Haider, Syed, D’Costa, Alister, Brookes, Cassandra L., van de Velde, Cornelis J. H., Hasenburg, Annette, Kieback, Dirk G., Markopoulos, Christos, Dirix, Luc, Seynaeve, Caroline, Rea, Daniel, Boutros, Paul C., Bartlett, John M. S.

“…Many women with hormone receptor-positive early breast cancer can be managed effectively with endocrine therapies alone. However, additional systemic…”
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Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER by van den Beucken, Twan, Koch, Elizabeth, Chu, Kenneth, Rupaimoole, Rajesha, Prickaerts, Peggy, Adriaens, Michiel, Voncken, Jan Willem, Harris, Adrian L., Buffa, Francesca M., Haider, Syed, Starmans, Maud H. W., Yao, Cindy Q., Ivan, Mircea, Ivan, Cristina, Pecot, Chad V., Boutros, Paul C., Sood, Anil K., Koritzinsky, Marianne, Wouters, Bradly G.

“…MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA…”
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Temporal Stability and Prognostic Biomarker Potential of the Prostate Cancer Urine miRNA Transcriptome by Jeon, Jouhyun, Olkhov-Mitsel, Ekaterina, Xie, Honglei, Yao, Cindy Q, Zhao, Fang, Jahangiri, Sahar, Cuizon, Carmelle, Scarcello, Seville, Jeyapala, Renu, Watson, John D, Fraser, Michael, Ray, Jessica, Commisso, Kristina, Loblaw, Andrew, Fleshner, Neil E, Bristow, Robert G, Downes, Michelle, Vesprini, Danny, Liu, Stanley, Bapat, Bharati, Boutros, Paul C

“…Abstract Background The development of noninvasive tests for the early detection of aggressive prostate tumors is a major unmet clinical need. miRNAs are…”
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Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study by Lalonde, Emilie, MSc, Ishkanian, Adrian S, MD, Sykes, Jenna, MMath, Fraser, Michael, PhD, Ross-Adams, Helen, PhD, Erho, Nicholas, MSc, Dunning, Mark J, PhD, Halim, Silvia, MSc, Lamb, Alastair D, FRCS, Moon, Nathalie C, MMath, Zafarana, Gaetano, PhD, Warren, Anne Y, FRCPath, Meng, Xianyue, MSc, Thoms, John, MD, Grzadkowski, Michal R, BMath, Berlin, Alejandro, MD, Have, Cherry L, BSc, Ramnarine, Varune R, BCS, Yao, Cindy Q, MSc, Malloff, Chad A, MSc, Lam, Lucia L, BSc, Xie, Honglei, MMath, Harding, Nicholas J, PhD, Mak, Denise Y F, PhD, Chu, Kenneth C, PhD, Chong, Lauren C, BCS, Sendorek, Dorota H, BSc, P'ng, Christine, BSc, Collins, Colin C, Prof, Squire, Jeremy A, Prof, Jurisica, Igor, Prof, Cooper, Colin, PhD, Eeles, Rosalind, Prof, Pintilie, Melania, MSc, Dal Pra, Alan, MD, Davicioni, Elai, PhD, Lam, Wan L, Prof, Milosevic, Michael, MD, Neal, David E, Prof, van der Kwast, Theodorus, Prof, Boutros, Paul C, Prof, Bristow, Robert G, Prof

“…Summary Background Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided…”
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Genome-wide germline correlates of the epigenetic landscape of prostate cancer by Houlahan, Kathleen E., Shiah, Yu-Jia, Gusev, Alexander, Yuan, Jiapei, Ahmed, Musaddeque, Shetty, Anamay, Ramanand, Susmita G., Yao, Cindy Q., Bell, Connor, O’Connor, Edward, Huang, Vincent, Fraser, Michael, Heisler, Lawrence E., Livingstone, Julie, Yamaguchi, Takafumi N., Rouette, Alexandre, Foucal, Adrien, Espiritu, Shadrielle Melijah G., Sinha, Ankit, Sam, Michelle, Timms, Lee, Johns, Jeremy, Wong, Ada, Murison, Alex, Orain, Michèle, Picard, Valérie, Hovington, Hélène, Bergeron, Alain, Lacombe, Louis, Lupien, Mathieu, Fradet, Yves, Têtu, Bernard, McPherson, John D., Pasaniuc, Bogdan, Kislinger, Thomas, Chua, Melvin L. K., Pomerantz, Mark M., van der Kwast, Theodorus, Freedman, Matthew L., Mani, Ram S., He, Housheng H., Bristow, Robert G., Boutros, Paul C.

“…Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We…”
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Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors by Lalonde, Emilie, Alkallas, Rached, Chua, Melvin Lee Kiang, Fraser, Michael, Haider, Syed, Meng, Alice, Zheng, Junyan, Yao, Cindy Q, Picard, Valerie, Orain, Michele, Hovington, Helène, Murgic, Jure, Berlin, Alejandro, Lacombe, Louis, Bergeron, Alain, Fradet, Yves, Têtu, Bernard, Lindberg, Johan, Egevad, Lars, Grönberg, Henrik, Ross-Adams, Helen, Lamb, Alastair D, Halim, Silvia, Dunning, Mark J, Neal, David E, Pintilie, Melania, van der Kwast, Theodorus, Bristow, Robert G, Boutros, Paul C

“…Abstract Background Localized prostate cancer is clinically heterogeneous, despite clinical risk groups that represent relative prostate cancer-specific…”
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Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer by Kim, Yunee, Ignatchenko, Vladimir, Yao, Cindy Q., Kalatskaya, Irina, Nyalwidhe, Julius O., Lance, Raymond S., Gramolini, Anthony O., Troyer, Dean A., Stein, Lincoln D., Boutros, Paul C., Medin, Jeffrey A., Semmes, O. John, Drake, Richard R., Kislinger, Thomas

“…Current protocols for the screening of prostate cancer cannot accurately discriminate clinically indolent tumors from more aggressive ones. One reliable…”
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Pathway-based subnetworks enable cross-disease biomarker discovery by Haider, Syed, Yao, Cindy Q., Sabine, Vicky S., Grzadkowski, Michal, Stimper, Vincent, Starmans, Maud H. W., Wang, Jianxin, Nguyen, Francis, Moon, Nathalie C., Lin, Xihui, Drake, Camilla, Crozier, Cheryl A., Brookes, Cassandra L., van de Velde, Cornelis J. H., Hasenburg, Annette, Kieback, Dirk G., Markopoulos, Christos J., Dirix, Luc Y., Seynaeve, Caroline, Rea, Daniel W., Kasprzyk, Arek, Lambin, Philippe, Lio’, Pietro, Bartlett, John M. S., Boutros, Paul C.

“…Biomarkers lie at the heart of precision medicine. Surprisingly, while rapid genomic profiling is becoming ubiquitous, the development of biomarkers usually…”
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NanoStringNormCNV: pre-processing of NanoString CNV data by Sendorek, Dorota H, Lalonde, Emilie, Yao, Cindy Q, Sabelnykova, Veronica Y, Bristow, Robert G, Boutros, Paul C

“…Abstract Summary The NanoString System is a well-established technology for measuring RNA and DNA abundance. Although it can estimate copy number variation,…”
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