Search Results - "Yao, Bu‐Fan"

Machine Learning: A New Approach for Dose Individualization by Li, Qiu‐Yue, Tang, Bo‐Hao, Wu, Yue‐E, Yao, Bu‐Fan, Zhang, Wei, Zheng, Yi, Zhou, Yue, Anker, John, Hao, Guo‐Xiang, Zhao, Wei

“…The application of machine learning (ML) has shown promising results in precision medicine due to its exceptional performance in dealing with complex…”
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Optimal dose of meropenem for the treatment of neonatal sepsis: Dosing guideline variations and clinical practice deviations by Raza, Muhammad Ahmer, Yao, Bu‐Fan, Shi, Hai‐Yan, Xu, Hai‐Yan, Hao, Guo‐Xiang, Van Den Anker, John, Zhao, Wei

“…Aims Meropenem is increasingly used to treat neonatal sepsis. There are several guidelines recommending different dosing regimens of meropenem in neonates…”
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Clinical utility of a model‐based amoxicillin dosage regimen in neonates with early‐onset sepsis by Kou, Chen, Li, Di‐Fei, Tang, Bo‐Hao, Dong, Lei, Yao, Bu‐Fan, Anker, John, You, Dian‐Ping, Wu, Yue‐E, Zhao, Wei

“…Early‐onset sepsis (EOS) is one of the most significant causes of morbidity and mortality in neonates. Currently, amoxicillin is empirically used to treat…”
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Clinical utiliy of a model‐based piperacillin dose in neonates with early‐onset sepsis by Wu, Yue‐E, Hou, Shan‐Shan, Fang, Zeng‐Yu, Tang, Bo‐Hao, Yao, Bu‐Fan, Dong, Yi‐Ning, Li, Xue, Shi, Hai‐Yan, Zheng, Yi, Hao, Guo‐Xiang, Huang, Xin, Van Den Anker, John, Yu, Yong‐Hui, Zhao, Wei

“…Aims Early‐onset sepsis (EOS) is a common disease in neonates with a high morbidity and mortality rate. Piperacillin/tazobactam has been used extensively and…”
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Population pharmacokinetics-pharmacodynamics of ceftazidime in neonates and young infants: Dosing optimization for neonatal sepsis by Li, Xue, Qi, Hui, Jin, Fei, Yao, Bu-Fan, Wu, Yue-E, Qi, Yu-Jie, Kou, Chen, Wu, Xi-Rong, Luo, Xiao-Jing, Shen, Yan-Hua, Zheng, Xu, Wang, Yong-Hong, Xu, Fang, Jiao, Wei-Wei, Li, Jie-Qiong, Xiao, Jing, Dong, Yi-Ning, Du, Bin, Shi, Hai-Yan, Xu, Bao-Ping, Shen, A-Dong, Zhao, Wei

“…Ceftazidime is a third-generation cephalosporin with high activity against many pathogens. But the ambiguity and diversity of the dosing regimens in neonates…”
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Optimal Sample Size for Use in Neonatal Pharmacokinetic Studies by Tang, Bo-Hao, Yao, Bu-Fan, van den Anker, John, Zhao, Wei

“…In recent years, population pharmacokinetics (PK) has been widely used in neonatal pharmacology. However, the sample size selection for neonatal PK studies has…”
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Developmental Population Pharmacokinetics and Dosing Optimization of Cefepime in Neonates and Young Infants by Zhao, Yang, Yao, Bu-Fan, Kou, Chen, Xu, Hai-Yan, Tang, Bo-Hao, Wu, Yue-E, Hao, Guo-Xiang, Zhang, Xin-Ping, Zhao, Wei

“…Cefepime is used to treat severe infections in neonates. Pharmacokinetic data have only been evaluated among preterm neonates and population pharmacokinetic…”
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Developmental Population Pharmacokinetics-Pharmacodynamics of Meropenem in Chinese Neonates and Young Infants: Dosing Recommendations for Late-Onset Sepsis by Wu, Yue-E, Kou, Chen, Li, Xue, Tang, Bo-Hao, Yao, Bu-Fan, Hao, Guo-Xiang, Zheng, Yi, van den Anker, John, You, Dian-Ping, Shen, A-Dong, Zhao, Wei

“…The pharmacokinetic (PK) studies of meropenem in Chinese newborns with late-onset sepsis (LOS) are still lacking. Causative pathogens of LOS and their…”
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Population Pharmacokinetic Study of Cefathiamidine in Infants With Augmented Renal Clearance by Du, Bin, Zhou, Yue, Tang, Bo-Hao, Wu, Yue-E, Yang, Xin-Mei, Shi, Hai-Yan, Yao, Bu-Fan, Hao, Guo-Xiang, You, Dian-Ping, van den Anker, John, Zheng, Yi, Zhao, Wei

“…Augmented renal clearance (ARC) of primarily renally eliminated antibacterial agents may result in subtherapeutic antibiotic concentrations and, as a…”
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Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates by Tang, Bo-Hao, Zhang, Jin-Yuan, Allegaert, Karel, Hao, Guo-Xiang, Yao, Bu-Fan, Leroux, Stephanie, Thomson, Alison H., Yu, Ze, Gao, Fei, Zheng, Yi, Zhou, Yue, Capparelli, Edmund V., Biran, Valerie, Simon, Nicolas, Meibohm, Bernd, Lo, Yoke-Lin, Marques, Remedios, Peris, Jose-Esteban, Lutsar, Irja, Saito, Jumpei, Jacqz-Aigrain, Evelyne, van den Anker, John, Wu, Yue-E., Zhao, Wei

“…Background and Objective High variability in vancomycin exposure in neonates requires advanced individualized dosing regimens. Achieving steady-state trough…”
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Population pharmacokinetics and dosing optimization of mezlocillin in neonates and young infants by Zhou, Jing, Jiang, Li, Zhang, Zhi Ling, Wang, Zhao Rui, Zhang, Yan Xiu, Lin, Xu, Tang, Bo Hao, Yao, Bu Fan, Guo, Zi Xuan, Yang, Jing Jing, Van Den Anker, John, Wu, Yue E, Zhao, Wei

“…Abstract Objectives Mezlocillin is used in the treatment of neonatal infectious diseases. However, due to the absence of population pharmacokinetic studies in…”
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Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction by Tang, Bo-Hao, Guan, Zheng, Allegaert, Karel, Wu, Yue-E., Manolis, Efthymios, Leroux, Stephanie, Yao, Bu-Fan, Shi, Hai-Yan, Li, Xiao, Huang, Xin, Wang, Wen-Qi, Shen, A.-Dong, Wang, Xiao-Ling, Wang, Tian-You, Kou, Chen, Xu, Hai-Yan, Zhou, Yue, Zheng, Yi, Hao, Guo-Xiang, Xu, Bao-Ping, Thomson, Alison H., Capparelli, Edmund V., Biran, Valerie, Simon, Nicolas, Meibohm, Bernd, Lo, Yoke-Lin, Marques, Remedios, Peris, Jose-Esteban, Lutsar, Irja, Saito, Jumpei, Burggraaf, Jacobus, Jacqz-Aigrain, Evelyne, van den Anker, John, Zhao, Wei

“…Background Population pharmacokinetic evaluations have been widely used in neonatal pharmacokinetic studies, while machine learning has become a popular…”
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Population pharmacokinetics and dosing optimization of azlocillin in neonates with early-onset sepsis: a real-world study by Wu, Yue-E, Wang, Tao, Yang, Hua-Liang, Tang, Bo-Hao, Kong, Li, Li, Xin, Gao, Qi, Li, Xue, Yao, Bu-Fan, Shi, Hai-Yan, Huang, Xin, Wang, Wen-Qi, Jacqz-Aigrain, Evelyne, Allegaert, Karel, van den Anker, John, Tian, Xiu-Ying, Zhao, Wei

“…Abstract Objectives Nowadays, real-world data can be used to improve currently available dosing guidelines and to support regulatory approval of drugs for use…”
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A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects by Yang, Xin-Mei, Yang, Yang, Yao, Bu-Fan, Ye, Pan-Pan, Xu, Yan, Peng, Shao-Ping, Yang, Yu-Mei, Shu, Pan, Li, Pei-Jin, Li, Shan, Hu, Hong-Lin, Li, Qian, Song, Lin-Lin, Chen, Ke-Guang, Zhou, Hai-Yan, Zhang, Ye-Hui, Zhao, Fu-Rong, Tang, Bo-Hao, Zhang, Wei, Zhang, Xin-Fang, Fu, Shu-Meng, Hao, Guo-Xiang, Zheng, Yi, Shen, Jing-Shan, Xu, Ye-Chun, Jiang, Xiang-Rui, Zhang, Lei-Ke, Tang, Ren-Hong, Zhao, Wei

“…Safe and efficacious antiviral therapeutics are in urgent need for the treatment of coronavirus disease 2019. Simnotrelvir is a selective 3C-like protease…”
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Aciclovir CSF concentration in children with viral encephalitis: is it adequate? by Sun, Su-Zhen, Wang, Le, Wu, Yue-E, Ma, Gui-Lin, Yao, Bu-Fan, Dong, Lei, Jacqz-Aigrain, Evelyne, Shi, Zhong-Ren, Zhao, Wei

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18 Use of machine learning for dosage individualization of vancomycin in neonates by Tang, Bo-Hao, Zhang, Jin-Yuan, Allegaert, Karel, Hao, Guo-Xiang, Yao, Bu-Fan, Leroux, Stephanie, Thomson, Alison H, Yu, Ze, Gao, Fei, Zheng, Yi, Zhou, Yue, Capparelli, Edmund V, Biran, Valerie, Simon, Nicolas, Meibohm, Bernd, Lo, Yoke-Lin, Marques, Remedios, Peris, Jose-Esteban, Lutsar, Irja, Saito, Jumpei, Jacqz-Aigrain, Evelyne, Anker, John van den, Wu, Yue-E, Zhao, Wei

“…IntroductionHigh variability in vancomycin exposure in neonates requires advanced individualized dosing regimens. Achieving steady-state trough concentration…”
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21 A first-in-human phase 1 study of SIM0417, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects by Yang, Xin-Mei, Yang, Yang, Yao, Bu-Fan, Ye, Pan-Pan, Xu, Yan, Peng, Shao-Ping, Yang, Yu-Mei, Shu, Pan, Li, Pei-Jin, Li, Shan, Hu, Hong-Lin, Li, Qian, Song, Lin-Lin, Chen, Ke-Guang, Zhou, Hai-Yan, Zhang, Ye-Hui, Zhao, Fu-Rong, Tang, Bo-Hao, Zhang, Wei, Zhang, Xin-Fang, Fu, Shu-Meng, Hao, Guo-Xiang, Zheng, Yi, Shen, Jing-Shan, Xu, Ye-Chun, Jiang, Xiang-Rui, Zhang, Lei-Ke, Tang, Ren-Hong, Zhao, Wei

“…IntroductionSafe and efficacious antiviral therapeutics are in urgent need for treatment of coronavirus disease 2019. SIM0417 is a selective 3C-like protease…”
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Model-informed drug development in pediatric, pregnancy and geriatric drug development: States of the art and future by Wu, Yue-E, Zheng, Yuan-Yuan, Li, Qiu-Yue, Yao, Bu-Fan, Cao, Jing, Liu, Hui-Xin, Hao, Guo-Xiang, van den Anker, John, Zheng, Yi, Zhao, Wei

“…[Display omitted] The challenges of drug development in pediatric, pregnant and geriatric populations are a worldwide concern shared by regulatory authorities,…”
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Predictive Performance of Pharmacokinetic Model-Based Virtual Trials of Vancomycin in Neonates: Mathematics Matches Clinical Observation by Yao, Bu-Fan, Wu, Yue-E, Tang, Bo-Hao, Hao, Guo-Xiang, Jacqz-Aigrain, Evelyne, van den Anker, John, Zhao, Wei

“…Background and Objective Vancomycin is frequently used to treat Gram-positive bacterial infections in neonates. However, there is still no consensus on the…”
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Machine Learning Approach in Dosage Individualization of Isoniazid for Tuberculosis by Tang, Bo-Hao, Zhang, Xin-Fang, Fu, Shu-Meng, Yao, Bu-Fan, Zhang, Wei, Wu, Yue-E., Zheng, Yi, Zhou, Yue, van den Anker, John, Huang, Hai-Rong, Hao, Guo-Xiang, Zhao, Wei

“…Introduction Isoniazid is a first-line antituberculosis agent with high variability, which would profit from individualized dosing. Concentrations of isoniazid…”
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