Search Results - "Yao, Betty B."

Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity by Frost, Jennifer M, Dart, Michael J, Tietje, Karin R, Garrison, Tiffany R, Grayson, George K, Daza, Anthony V, El-Kouhen, Odile F, Yao, Betty B, Hsieh, Gin C, Pai, Madhavi, Zhu, Chang Z, Chandran, Prasant, Meyer, Michael D

“…Several 3-acylindoles with high affinity for the CB2 cannabinoid receptor and selectivity over the CB1 receptor have been prepared. A variety of 3-acyl…”
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Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats by Hsieh, Gin C, Pai, Madhavi, Chandran, Prasant, Hooker, Bradley A, Zhu, Chang Z, Salyers, Anita K, Wensink, Erica J, Zhan, CenChen, Carroll, William A, Dart, Michael J, Yao, Betty B, Honore, Prisca, Meyer, Michael D

“…BACKGROUND AND PURPOSE Cannabinoid CB2 receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of…”
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Effects of a ritonavir‐containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects by Zha, Jiuhong, Jiang, Qi, Yao, Betty B., Cohen, Daniel E., Carter, David C., Menon, Rajeev M.

“…The immunosuppressive agents sirolimus and everolimus are sensitive CYP3A4 substrates with narrow therapeutic index. Ritonavir is a strong CYP3A inhibitor. A…”
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Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist by Fox, Gerard B, Esbenshade, Timothy A, Pan, Jia Bao, Radek, Richard J, Krueger, Kathleen M, Yao, Betty B, Browman, Kaitlin E, Buckley, Michael J, Ballard, Michael E, Komater, Victoria A, Miner, Holly, Zhang, Min, Faghih, Ramin, Rueter, Lynne E, Bitner, R Scott, Drescher, Karla U, Wetter, Jill, Marsh, Kennan, Lemaire, Martine, Porsolt, Roger D, Bennani, Youssef L, Sullivan, James P, Cowart, Marlon D, Decker, Michael W, Hancock, Arthur A

“…Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is little information available…”
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Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging by Yao, Betty B, Hsieh, Gin, Daza, Anthony V, Fan, Yihong, Grayson, George K, Garrison, Tiffany Runyan, El Kouhen, Odile, Hooker, Bradley A, Pai, Madhavi, Wensink, Erica J, Salyers, Anita K, Chandran, Prasant, Zhu, Chang Z, Zhong, Chengmin, Ryther, Keith, Gallagher, Megan E, Chin, Chih-Liang, Tovcimak, Ann E, Hradil, Vincent P, Fox, Gerard B, Dart, Michael J, Honore, Prisca, Meyer, Michael D

“…Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB(2) receptor activation have been largely derived from the use of…”
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Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir and With or Without Ribavirin for Adolescents With HCV Genotype 1 or 4 by Leung, Daniel H., Wirth, Stefan, Yao, Betty B., Viani, Rolando M., Gonzalez‐Peralta, Regino P., Jonas, Maureen M., Lobritto, Steven J., Narkewicz, Michael R., Sokal, Etienne, Fortuny, Clàudia, Hsu, Evelyn K., Del Valle‐Segarra, Antonio, Zha, Jiuhong, Larsen, Lois, Liu, Li, Shuster, Diana L., Cohen, Daniel E., Rosenthal, Philip

“…In adults, treatment of hepatitis C virus (HCV) infection with ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) with or without dasabuvir (DSV) and ±ribavirin…”
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Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization by Fox, Gerard B, Pan, Jia Bao, Radek, Richard J, Lewis, Angela M, Bitner, R Scott, Esbenshade, Timothy A, Faghih, Ramin, Bennani, Youssef L, Williams, Michael, Yao, Betty B, Decker, Michael W, Hancock, Arthur A

“…Pharmacological blockade of central histamine H3 receptors (H3Rs) enhances cognition in rodents and offers promise for the clinical treatment of neurological…”
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Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects by Esbenshade, Timothy A, Krueger, Kathleen M, Miller, Thomas R, Kang, Chae Hee, Denny, Lynne I, Witte, David G, Yao, Betty B, Fox, Gerard B, Faghih, Ramin, Bennani, Youssef L, Williams, Michael, Hancock, Arthur A

“…Histamine H3 receptor (H3R) antagonists enhance neurotransmitter release and are being developed for the treatment of a variety of neurological and cognitive…”
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Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist by ESBENSHADE, Timothy A, FOX, Gerard B, FAGHIH, Ramin, BENNANI, Youssef L, WILLIAMS, Michael, HANCOCK, Arthur A, KRUEGER, Kathleen M, BARANOWSKI, John L, MILLER, Thomas R, CHAE HEE KANG, DENNY, Lynne I, WITTE, David G, YAO, Betty B, JIA BAO PAN

“…Histamine H3 receptors regulate the release of a variety of central neurotransmitters involved in cognitive processes. A-349821…”
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Phase 1 study of safety and tolerability of an oral contraceptive containing low‐dose ethinyl oestradiol combined with glecaprevir/pibrentasvir treatment in healthy premenopausal women by Shiller, Dee‐Dee, Yao, Betty B., Chen, Mong‐Jen, Orejudos, Amelia, Mostafa, Nael M., Marcinak, John F., Burroughs, Margaret, Boyle, Craig

“…Glecaprevir/pibrentasvir (GLE/PIB) is an approved guideline‐recommended chronic hepatitis C virus infection treatment. GLE/PIB coadministration with ethinyl…”
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Durability of sustained virological response to glecaprevir/pibrentasvir and resistance development: A long‐term follow‐up study by Poordad, Fred, Felizarta, Franco, Yao, Betty B., Overcash, J. Scott, Hassanein, Tarek, Agarwal, Kosh, Gane, Edward, Shaw, David, Waters, Michael, Krishnan, Preethi, Topp, Andrew, Burroughs, Margaret, Nevens, Frederik

“…Background and Aims This study aimed to determine durability of sustained virologic response (SVR) in hepatitis C virus‐infected participants treated with…”
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Central and peripheral sites of action for CB 2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats by Hsieh, Gin C, Pai, Madhavi, Chandran, Prasant, Hooker, Bradley A, Zhu, Chang Z, Salyers, Anita K, Wensink, Erica J, Zhan, CenChen, Carroll, William A, Dart, Michael J, Yao, Betty B, Honore, Prisca, Meyer, Michael D

“…BACKGROUND AND PURPOSE Cannabinoid CB 2 receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of…”
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Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 or 6 infection (ENDURANCE-5,6): an open-label, multicentre, phase 3b trial by Asselah, Tarik, Lee, Samuel S, Yao, Betty B, Nguyen, Tuan, Wong, Florence, Mahomed, Adam, Lim, Seng Gee, Abergel, Armand, Sasadeusz, Joe, Gane, Edward, Zadeikis, Neddie, Schnell, Gretja, Zhang, Zhenzhen, Porcalla, Ariel, Mensa, Federico J, Nguyen, Kinh

“…The pangenotypic direct-acting antiviral regimen of glecaprevir coformulated with pibrentasvir is approved to treat chronic hepatitis C virus (HCV) genotype…”
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Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels by Bianchi, Bruce R, Zhang, Xu-Feng, Reilly, Regina M, Kym, Philip R, Yao, Betty B, Chen, Jun

“…The transient receptor potential ankyrin-1 (TRPA1) channel has emerged as an attractive target for development of analgesic and anti-inflammatory drugs…”
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Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3–11 Years with Hepatitis C Genotype 1a by Rosenthal, Philip, Narkewicz, Michael R., Yao, Betty B., Jolley, Christopher D., Lobritto, Steven J., Wen, Jessica, Molleston, Jean P., Hsu, Evelyn K., Jonas, Maureen M., Zha, Jiuhong, Liu, Li, Leung, Daniel H.

“…Introduction To assess the safety, efficacy, and pharmacokinetics of mini-tablet formulations of ombitasvir (OBV), paritaprevir (PTV), ritonavir, and dasabuvir…”
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Efficacy and safety of glecaprevir/pibrentasvir in patients with HCV genotype 5/6: An integrated analysis of phase 2/3 studies by Yao, Betty B., Fredrick, Linda M., Schnell, Gretja, Kowdley, Kris V., Kwo, Paul Y., Poordad, Fred, Nguyen, Kinh, Lee, Samuel S., George, Christophe, Wong, Florence, Gane, Edward, Abergel, Armand, Spearman, Catherine W., Nguyen, Tuan, Hung Le, Manh, Pham, Thuy TT, Mensa, Federico, Asselah, Tarik, Dore, Gregory

“…Background & Aims Hepatitis C virus (HCV) has high genetic diversity with six major genotypes (GT) GT1‐6 and global distribution. HCV GT5 and 6 are rare…”
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Indol-3-yl-tetramethylcyclopropyl Ketones: Effects of Indole Ring Substitution on CB2 Cannabinoid Receptor Activity by Frost, Jennifer M, Dart, Michael J, Tietje, Karin R, Garrison, Tiffany R, Grayson, George K, Daza, Anthony V, El-Kouhen, Odile F, Miller, Loan N, Li, Lanlan, Yao, Betty B, Hsieh, Gin C, Pai, Madhavi, Zhu, Chang Z, Chandran, Prasant, Meyer, Michael D

“…A series of potent indol-3-yl-tetramethylcyclopropyl ketones have been prepared as CB2 cannabinoid receptor ligands. Two unsubstituted indoles (5, 32) were the…”
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Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist by HANCOCK, Arthur A, BENNANI, Youssef L, JIA BAO PAN, SHAPIRO, Robin, WITTE, David G, YAO, Betty B, BUSH, Eugene N, ESBENSHADE, Timothy A, FAGHIH, Ramin, FOX, Gerard B, JACOBSON, Peer, KNOUREK-SEGEL, Victoria, KRUEGER, Kathleen M, NUSS, Merrill E

“…Histamine affects homeostatic mechanisms, including food and water consumption, by acting on central nervous system (CNS) receptors. Presynaptic histamine H(3)…”
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KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels by Zhang, Di, Thimmapaya, Rama, Zhang, Xu-Feng, Anderson, David J., Baranowski, John L., Scanio, Marc, Perez-Medrano, Arturo, Peddi, Sridhar, Wang, Zhi, Patel, Jyoti R., DeGoey, David A., Gopalakrishnan, Murali, Honore, Prisca, Yao, Betty B., Surowy, Carol S.

“…► Tl + influx assays were developed to profile the molecular pharmacology of KCNQ2/3 openers over multiple KCNQ channels in parallel. ► Two novel series of…”
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Characterization of human cannabinoid CB2 receptor coupled to chimeric Gαqi5 and Gαqo5 proteins by MALYSZ, John, DAZA, Anthony V, KAGE, Karen, GRAYSON, George K, YAO, Betty B, MEYER, Michael D, GOPALAKRISHNAN, Murali

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