Search Results - "Yanvarev, Dmitry"
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Recognition of 3′ nucleotide context and stop codon readthrough are determined during mRNA translation elongation
Published in The Journal of biological chemistry (01-07-2022)“…The nucleotide context surrounding stop codons significantly affects the efficiency of translation termination. In eukaryotes, various 3′ contexts that are…”
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2
Depleting hepatitis B virus relaxed circular DNA is necessary for resolution of infection by CRISPR-Cas9
Published in Molecular therapy. Nucleic acids (14-03-2023)“…CRISPR-Cas9 systems can directly target the hepatitis B virus (HBV) major genomic form, covalently closed circular DNA (cccDNA), for decay and demonstrate…”
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Phosphorylation and Dephosphorylation of Beta-Amyloid Peptide in Model Cell Cultures: The Role of Cellular Protein Kinases and Phosphatases
Published in Life (Basel, Switzerland) (01-01-2023)“…Phosphorylation of beta-amyloid peptide (Aβ) at the Ser8 residue affects its neurotoxicity, metal-dependent oligomerisation, amyloidogenicity, and other…”
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4
SARS-CoV-2 Establishes a Productive Infection in Hepatoma and Glioblastoma Multiforme Cell Lines
Published in Cancers (19-01-2023)“…Severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and rapidly caused a pandemic that led to the death of >6…”
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5
Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase
Published in Biomolecules (Basel, Switzerland) (06-03-2020)“…The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells…”
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6
Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle
Published in Cells (Basel, Switzerland) (14-06-2024)“…Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting…”
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On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge
Published in Molecules (Basel, Switzerland) (23-06-2017)“…Derivatives of methylenediphosphonic acid possess wide spectra of biological activities and are used in enzymology as research tools as well as in practical…”
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Polyamine Catabolism Revisited: Acetylpolyamine Oxidase Plays a Minor Role due to Low Expression
Published in Cells (Basel, Switzerland) (01-07-2024)“…Biogenic polyamines are ubiquitous compounds. Dysregulation of their metabolism is associated with the development of various pathologies, including cancer,…”
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Antiviral Properties, Metabolism, and Pharmacokinetics of a Novel Azolo-1,2,4-Triazine-Derived Inhibitor of Influenza A and B Virus Replication
Published in Antimicrobial Agents and Chemotherapy (01-05-2010)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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5'-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms : Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
Published in Drug metabolism and disposition (01-03-2009)“…The main disadvantages of 3'-azido-3'-deoxythymidine (zidovudine, AZT), the most common anti-HIV drug, are toxicity and a short half-life in the organism. The…”
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11
Uncharged AZT and D4T Derivatives of Phosphonoformic and Phosphonoacetic Acids as Anti-HIV Pronucleosides
Published in Journal of medicinal chemistry (01-07-2004)“…Two series of new lipophilic phosphonoformate and phosphonoacetate derivatives of AZT and d4T were synthesized and evaluated as anti-HIV agents. The efficacy…”
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Termination of translation in eukaryotes is mediated by the quaternary eRF1 eRF3 GTP Mg²⁺ complex. The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct
Published in Nucleic acids research (01-01-2006)“…GTP hydrolysis catalyzed in the ribosome by a complex of two polypeptide release factors, eRF1 and eRF3, is required for fast and efficient termination of…”
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AZT 5′-Cholinephosphate as an Anti-HIV Agent: The Study of Biochemical Properties and Metabolic Transformations Using Its 32P-Labelled Counterpart
Published in Nucleosides, nucleotides & nucleic acids (01-01-2007)“…Biochemical and metabolic transformations of 3′-azido-3′-deoxythymidine 5′-choline phosphate (1) were studied using its 32 P-labelled counterpart for the…”
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14
5′-Carbamoylphosphonyl-[6-3H]-AZT as a Tool for Studying Metabolic Transformations of the Nonradioactive Counterpart, an Inhibitor of HIV Replication
Published in Nucleosides, nucleotides & nucleic acids (01-01-2007)“…An effective synthesis of 5′-carbamoylphosphonyl-[6-3H]-AZT was developed from [6-3H]-AZT.For the synthesized compound, chemical and enzymatic stability were…”
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15
Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives
Published in European journal of medicinal chemistry (12-02-2014)“…The integration of viral DNA into the cell genome is one of the key steps in the replication cycle of human immunodeficiency virus type 1 (HIV-1). Therefore,…”
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A new fluorometric assay for the study of DNA-binding and 3′-processing activities of retroviral integrases and its use for screening of HIV-1 integrase inhibitors
Published in Biochimie (01-11-2012)“…Fluorometry using a substrate DNA labeled with a single fluorophore (6-carboxyfluorescein) at the 3′-end of the processed strand was shown to be a useful tool…”
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17
New Lipophilic Derivatives of AZT and d4T 5′-Phosphonates
Published in Nucleosides, nucleotides & nucleic acids (01-10-2003)“…5′-Aminocarbonylphosphonyl and aminocarbonylmethylphosphonyl diesters of AZT and d4T were synthesized as potential anti-HIV agents…”
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New Nucleoside and bis-Nucleoside-Phosphonate Conjugates: Design, Stability, and Anti-HIV Evaluation
Published in Antiviral research (01-04-2010)Get full text
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Termination of translation in eukaryotes is mediated by the quaternary eRF1 times eRF3 times GTP times Mg super(2+) complex. The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct
Published in Nucleic acids research (01-01-2006)“…GTP hydrolysis catalyzed in the ribosome by a complex of two polypeptide release factors, eRF1 and eRF3, is required for fast and efficient termination of…”
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Journal Article -
20
Termination of translation in eukaryotes is mediated by the quaternary eRF1eRF3GTPMg2+ complex. The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct
Published in Nucleic acids research (2006)“…GTP hydrolysis catalyzed in the ribosome by a complex of two polypeptide release factors, eRF1 and eRF3, is required for fast and efficient termination of…”
Get full text
Journal Article