Search Results - "Yant, Stephen R."

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid by Peng, Ke, Muranyi, Walter, Glass, Bärbel, Laketa, Vibor, Yant, Stephen R, Tsai, Luong, Cihlar, Tomas, Müller, Barbara, Kräusslich, Hans-Georg

“…The steps from HIV-1 cytoplasmic entry until integration of the reverse transcribed genome are currently enigmatic. They occur in ill-defined…”
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Long-acting lenacapavir acts as an effective preexposure prophylaxis in a rectal SHIV challenge macaque model by Bekerman, Elena, Yant, Stephen R, VanderVeen, Laurie, Hansen, Derek, Lu, Bing, Rowe, William, Wang, Kelly, Callebaut, Christian

“…Long-acting antiretroviral agents for preexposure prophylaxis (PrEP) represent a promising new alternative to daily oral regimens for HIV prevention…”
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Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells by Balakrishnan, Mini, Yant, Stephen R, Tsai, Luong, O'Sullivan, Christopher, Bam, Rujuta A, Tsai, Angela, Niedziela-Majka, Anita, Stray, Kirsten M, Sakowicz, Roman, Cihlar, Tomas

“…HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-transfer inhibitors (INSTIs) and ii) the non-catalytic site…”
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The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9 by AKACHE, Bassel, GRIMM, Dirk, PANDEY, Kusum, YANT, Stephen R, HUI XU, KAY, Mark A

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Sarcoma Derived from Cultured Mesenchymal Stem Cells by Tolar, Jakub, Nauta, Alma J., Osborn, Mark J., Panoskaltsis Mortari, Angela, McElmurry, Ron T., Bell, Scott, Xia, Lily, Zhou, Ning, Riddle, Megan, Schroeder, Tania M., Westendorf, Jennifer J., McIvor, R. Scott, Hogendoorn, Pancras C.W., Szuhai, Karoly, Oseth, LeAnn, Hirsch, Betsy, Yant, Stephen R., Kay, Mark A., Peister, Alexandra, Prockop, Darwin J., Fibbe, Willem E., Blazar, Bruce R.

“…To study the biodistribution of MSCs, we labeled adult murine C57BL/6 MSCs with firefly luciferase and DsRed2 fluorescent protein using nonviral Sleeping…”
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High-Resolution Genome-Wide Mapping of Transposon Integration in Mammals by Yant, Stephen R., Wu, Xiaolin, Huang, Yong, Garrison, Brian, Burgess, Shawn M., Kay, Mark A.

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Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir by STRAY, Kirsten M, BAM, Rujuta A, BIRKUS, Gabriel, JIA HAO, LEPIST, Eve-Irene, YANT, Stephen R, RAY, Adrian S, CIHLAR, Tomas

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Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system by Kay, Mark A, Yant, Stephen R, Meuse, Leonard, Chiu, Winnie, Ivics, Zoltan, Izsvak, Zsuzsanna

“…The development of non-viral gene-transfer technologies that can support stable chromosomal integration and persistent gene expression in vivo is desirable…”
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Postintegrative Gene Silencing within the Sleeping Beauty Transposition System by Garrison, Brian S., Yant, Stephen R., Mikkelsen, Jacob Giehm, Kay, Mark A.

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Mutational Analysis of the N-Terminal DNA-Binding Domain of Sleeping Beauty Transposase: Critical Residues for DNA Binding and Hyperactivity in Mammalian Cells by Yant, Stephen R., Park, Julie, Huang, Yong, Mikkelsen, Jacob Giehm, Kay, Mark A.

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Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo by Kay, Mark A, Yant, Stephen R, Ehrhardt, Anja, Mikkelsen, Jacob Giehm, Meuse, Leonard, Pham, Thao

“…A major limitation of adenovirus-mediated gene therapy for inherited diseases is the instability of transgene expression in vivo, which originates at least in…”
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A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 and 8 by Akache, Bassel, Grimm, Dirk, Shen, Xuan, Fuess, Sally, Yant, Stephen R, Glazer, Dariya S, Park, Julie, Kay, Mark A

“…Vectors based on different serotypes of adeno-associated virus hold great promise for human gene therapy, based on their unique tissue tropisms and distinct…”
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Clinical targeting of HIV capsid protein with a long-acting small molecule by Link, John O., Rhee, Martin S., Tse, Winston C., Zheng, Jim, Somoza, John R., Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K., Bam, Rujuta A., Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R., Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L., Saito, Roland D., Schroeder, Scott D., Lazerwith, Scott E., Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G., Cannizzaro, Carina E., Hu, Eric Y., Anderson, Robert L., Appleby, Todd C., Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A., Wong, Melanie H., Leavitt, Stephanie A., Xu, Yili, Koditek, David, Stepan, George J., Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z., Sellers, Scott, Wolckenhauer, Scott A., Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R., Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I., Ruane, Peter J., Crofoot, Gordon E., McDonald, Cheryl K., Brainard, Diana M., Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I., Sakowicz, Roman, Chester, Anne E., Lee, William E., Daar, Eric S., Yant, Stephen R., Cihlar, Tomas

“…Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis 1…”
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Nonhomologous-End-Joining Factors Regulate DNA Repair Fidelity during Sleeping Beauty Element Transposition in Mammalian Cells by Yant, Stephen R., Kay, Mark A.

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In Vivo Correction of Murine Tyrosinemia Type I by DNA-Mediated Transposition by Montini, Eugenio, Held, Patrice K., Noll, Meenakshi, Morcinek, Nicolas, Al-Dhalimy, Muhsen, Finegold, Milton, Yant, Stephen R., Kay, Mark A., Grompe, Markus

“…Gene therapy applications of naked DNA constructs for genetic disorders have been limited because of lack of permanent transgene expression. This limitation,…”
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Linear DNAs Concatemerize in Vivo and Result in Sustained Transgene Expression in Mouse Liver by Chen, Zhi-Ying, Yant, Stephen R., He, Cheng-Yi, Meuse, Leonard, Shen, Shiliang, Kay, Mark A.

“…The short duration of transgene expression remains a major obstacle for the implementation of nonviral DNA vectors in clinical gene therapy trials. Here, we…”
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Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile by Tsiang, Manuel, Jones, Gregg S, Goldsmith, Joshua, Mulato, Andrew, Hansen, Derek, Kan, Elaine, Tsai, Luong, Bam, Rujuta A, Stepan, George, Stray, Kirsten M, Niedziela-Majka, Anita, Yant, Stephen R, Yu, Helen, Kukolj, George, Cihlar, Tomas, Lazerwith, Scott E, White, Kirsten L, Jin, Haolun

“…Bictegravir (BIC; GS-9883), a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase (IN), specifically targets IN strand transfer activity (50%…”
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Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity by Bam, Rujuta A, Yant, Stephen R, Cihlar, Tomas

“…Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that shows enhanced antiretroviral effect and reduced plasma tenofovir exposures at approximately…”
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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model by Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.

“…People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication…”
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Simulating HIV Breakthrough and Resistance Development During Variable Adherence to Antiretroviral Treatment by Mulato, Andrew, Acosta, Rima, Chang, Silvia, Martin, Ross, Yant, Stephen R., Cihlar, Tomas, White, Kirsten

“…BACKGROUND:Barriers to lifelong HIV-1 suppression by antiretrovirals include poor adherence and drug resistance; regimens with higher tolerance to missed doses…”
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