Search Results - "Yano, Max"

Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Pan, Alexander, Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrózek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Yan, Pearlly, Byrd, John C., Blachly, James S., Lapalombella, Rosa

“…Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the…”
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Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential by Yano, Max, Byrd, John C, Muthusamy, Natarajan

“…Immunotherapy approaches have advanced rapidly in recent years. While the greatest therapeutic advances so far have been achieved with T cell therapies such as…”
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Evaluation of membrane bound IL-21 expanded natural killer cells for chronic lymphocytic leukemia therapy by Yano, Max, Lance, J. Rachel, Zapolnik, Kevan, Mo, Xiaokui, Lee, Dean A, Byrd, John, Muthusamy, Natarajan

“…Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia and remains incurable despite recent therapeutic advances. Natural killer (NK) cells…”
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Activating Lymphocyte Reactions Against Chronic Lymphocytic Leukemia by Yano, Max

“…Strategies to harness the immune system to treat cancer have been pursued for decades, but only in the past ten years has this dream begun to be realized in…”
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IL-21-Expanded NK Cells As Autologous Cell Therapy for CLL by Lance, Jennie Rachel, Yano, Max, Mo, Xiaokui, Lee, Dean Anthony, Muthusamy, Natarajan, Byrd, John C.

“…Introduction: While treatments for CLL have improved in recent years, CLL remains incurable for most patients who often rely on long-term suppressive…”
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IL-21-Expanded Natural Killer Cells As Autologous Cell Therapy for CLL by Yano, Max, Lance, Jennie Rachel, Mo, Xiaokui, Lee, Dean Anthony, Muthusamy, Natarajan, Byrd, John C.

“…Introduction: While treatments for CLL have improved in recent years, CLL remains incurable for most patients who often rely on long-term suppressive…”
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Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma by Kohnken, Rebecca, Wen, Jing, Mundy-Bosse, Bethany, McConnell, Kathleen, Keiter, Ashleigh, Grinshpun, Leah, Hartlage, Alex, Yano, Max, McNeil, Betina, Chakravarti, Nitin, William, Basem, Bradner, James E., Caligiuri, Michael A., Porcu, Pierluigi, Mishra, Anjali

“…MicroRNA (miRNA) dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), an often-fatal malignancy of skin-homing CD4+ T cells for which there are few…”
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Abstract 3959: Ibrutinib immunomodulation via CTLA4 downregulation in CLL by Yano, Max, Do, Priscilla, Mo, Xiaokui, Muthusamy, Natarajan, Byrd, John C.

“…Chronic lymphocytic leukemia (CLL) is the most common lymphoid malignancy in the United States. It causes significant morbidity and mortality, largely through…”
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Patient characteristics that predict Richter's transformation in patients with chronic lymphocytic leukemia treated with ibrutinib by Kittai, Adam S., Huang, Ying, Beckwith, Kyle A., Bhat, Seema A., Bond, David A., Byrd, John C., Goldstein, Daniel, Grever, Michael R., Miller, Cecelia, Rogers, Kerry A., Yano, Max, Woyach, Jennifer A.

“…Chronic lymphocytic leukemia (CLL) transformation to aggressive lymphoma, known as Richter's Transformation (RT), has a dismal prognosis. There are limited…”
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Outcomes of Patients with Richter Transformation without Prior Chemoimmunotherapy for CLL/SLL: An International Multicenter Retrospective Study by Kittai, Adam S, Huang, Ying, Miller, Sarah, Allan, John N., Bhat, Seema A, Bond, David A., Brander, Danielle M, Byrd, John C., Chavez, Julio C, Chong, Elise A., Davids, Matthew S, Danilov, Alexey, Ding, Wei, Dowling, Mark R, Dvorak-Kornaus, Kaitlyn M., Freedman, Hannah, Hampel, Paul J, Ho, Carrie I, Hwang, Steven R, Islam, Prioty, Jain, Nitin, Matasar, Matthew, Miller, Cecelia, Parry, Erin M, Rabe, Kari G., Rai, Manoj, Raess, Phil, Roeker, Lindsey E., Rhodes, Joanna M., Rogers, Kerry A, Saha, Aditi, Schade, Jake, Scott, Hamish S, Shadman, Mazyar, Shouse, Geoffrey P., Skarbnik, Alan, Spurgeon, Stephen E, Stephens, Deborah M., Thompson, Meghan C., Thompson, Philip A., Wang, Yucai, Wierda, William G., Yano, Max, Zulfa, Omer, Woyach, Jennifer A.

“…Background: Richter Transformation (RT) refers to the development of an aggressive lymphoma in the setting of chronic lymphocytic leukemia/small lymphocytic…”
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Abstract 2260: Evaluating a rare t(X;14)(q28;q32) translocation reveals MTCP1 as a driving factor in chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrozek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Byrd, John C., Blachly, James S., Lapalombella, Rosa

“…Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in Western countries and is spelled by substantial genetic and clinical heterogeneity…”
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Targeting BRD4 Disables IL-15 Oncogenic Signaling in Cutaneous T-Cell Lymphoma Via Down Regulation of IL-15 Receptor Complex by Kohnken, Rebecca, Wen, Jing, Yano, Max, Hartlage, Alex, Grinshpun, Leah, Caligiuri, Michael A., Porcu, Pierluigi, Mishra, Anjali

“…Targeting the epigenome is a promising strategy in the treatment of advanced stage cutaneous T-cell lymphoma (CTCL). CTCL is a malignancy of mature CD4+…”
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Abstract 481: Diminished microRNA-29b results in overexpression of BRD4 and BRD4-regulated oncogenes in cutaneous T-cell lymphoma by Kohnken, Rebecca, Wen, Jing, Mundy-Bosse, Bethany, Yano, Max, Grinshpun, Leah, McConnell, Kathleen, Keiter, Ashleigh, Hartlage, Alex, Bradner, James, Caligiuri, Michael, Porcu, Pierluigi, Mishra, Anjali

“…Cutaneous T-cell lymphoma (CTCL) is a CD4+ T-cell malignancy that affects the skin but may disseminate systemically, and there are no long-term effective…”
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Differential regulation of CTLA4 expression through BTK-dependent and independent mechanisms in CLL by Yano, Max, Nunes, Jessica, Mo, Xiaokui, Rogers, Kerry A., Woyach, Jennifer A., Byrd, John C., Muthusamy, Natarajan

“…Cytotoxic T lymphocyte antigen 4 (CTLA4) is a major immune checkpoint and target for cancer immunotherapy. Although originally discovered and primarily studied…”
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Evaluation of allogeneic and autologous membrane-bound IL-21–expanded NK cells for chronic lymphocytic leukemia therapy by Yano, Max, Sharpe, Chia, Lance, J. Rachel, Ravikrishnan, Janani, Zapolnik, Kevan, Mo, Xiaokui, Woyach, Jennifer A., Sampath, Deepa, Kittai, Adam S., Vasu, Sumithira, Bhat, Seema, Rogers, Kerry A., Lee, Dean A., Muthusamy, Natarajan, Byrd, John C.

“…•Autologous and allogeneic NK cells stimulated with mbIL-21–expressing feeder cells show activity against CLL.•Expanded NK cells show efficacy in vitro and…”
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Par-4 overexpression impedes leukemogenesis in the Eµ-TCL1 leukemia model through downregulation of NF-κB signaling by Greene, J.T., Mani, Rajeswaran, Ramaswamy, Rahul, Frissora, Frank, Yano, Max, Zapolnik, Kevan, Harrington, Bonnie, Wasmuth, Ronni, Tran, Minh, Mo, Xiaokui, McKenna, Mary, Rangnekar, Vivek M., Byrd, John C., Bondada, Subbarao, Muthusamy, Natarajan

“…Prostate apoptosis response 4 (Par-4) is a tumor suppressor that prevents proliferation and induces cell death in several solid tumors. However, its role in…”
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