Search Results - "Yanni, John M."

Differential effects of non-steroidal anti-inflammatory drugs on mitochondrial dysfunction during oxidative stress by Lal, Nirupama, Kumar, Jitendra, Erdahl, Warren E., Pfeiffer, Douglas R., Gadd, Martha. E., Graff, Gustav, Yanni, John M.

“…We investigated the effects of several non-steroidal anti-inflammatory drugs on swelling related properties of mitochondria, with an emphasis on compounds that…”
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Water-soluble PDE4 inhibitors for the treatment of dry eye by Govek, Steven P., Oshiro, Guy, Anzola, John V., Beauregard, Clay, Chen, Jasmine, Coyle, Avery R., Gamache, Daniel A., Hellberg, Mark R., Hsien, Jennifer N., Lerch, Julia M., Liao, John C., Malecha, James W., Staszewski, Lena M., Thomas, David J., Yanni, John M., Noble, Stewart A., Shiau, Andrew K.

“…The development of a novel series of water-soluble PDE4 inhibitors led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a…”
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Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cells by Yanni, J M, Miller, S T, Gamache, D A, Spellman, J M, Xu, S, Sharif, N A

“…The concept of mast cell heterogeneity is well established. Recent data indicate that human conjunctival tissue mast cells and human connective tissue mast…”
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Preservation of corneal integrity by the mucin secretagogue 15(S)-HETE in a rabbit model of desiccation-induced dry eye by Gamache, Daniel A, Wei, Zhong-you, Weimer, Lori K, Spellman, Joan M, Yanni, John M

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Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines by Sharif, Najam A, Xu, Shouxi, Hellberg, Peggy E, Pang, Iok-Hou, Gamache, Daniel A, Yanni, John M

“…The aims of the study were to characterize the signal transduction responses to platelet-activating factor (PAF) and to monitor the downstream effects of PAF…”
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Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye by Nagelhout, Teann J, Gamache, Daniel A, Roberts, Leighann, Brady, Milton T, Yanni, John M

“…The aim of this study was to establish a clinically relevant short-term animal model of dry eye with utility in identifying compounds with potential…”
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Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs by Yanni, J M, Weimer, L K, Sharif, N A, Xu, S X, Gamache, D A, Spellman, J M

“…To evaluate the effects of topical ocular drugs with histamine H1-antagonist activity on histamine-stimulated phosphatidylinositol turnover and interleukin…”
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Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers by Ke, T L, Graff, G, Spellman, J M, Yanni, J M

“…Nepafenac, the amide analog of the NSAID amfenac, was examined in vitro for its bioactivation by ocular tissue components and its ability to permeate external…”
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Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy by Gamache, D A, Graff, G, Brady, M T, Spellman, J M, Yanni, J M

“…Nepafenac, the amide analog of 2-amino-3-benzoylbenzeneacetic acid (amfenac), was examined in preclinical models for its potential utility as a topical ocular…”
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Interactions of olopatadine and selected antihistamines with model and natural membranes by Brockman, Howard L., Momsen, Maureen M., Knudtson, Joshua R., Miller, Steven T., Graff, Gustav, Yanni, John M.

“…Objective: Olopatadine, an effective topical ocular human conjunctival mast cell stabilizer/antihistaminic antiallergic drug, was evaluated and compared to…”
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Preclinical and clinical antiallergic effect of olopatadine 0.2% solution 24 hours after topical ocular administration by Vogelson, Cullen T, Abelson, Mark B, Pasquine, Terri, Stephens, Donna M, Gamache, Daniel A, Gross, Robert D, Robertson, Stella M, Yanni, John M

“…Pharmacologic studies examined the potential of a solution containing olopatadine to maintain and extend antiallergic efficacy after single topical ocular drop…”
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Corneal protection by the ocular mucin secretagogue 15(S)-HETE in a rabbit model of desiccation-induced corneal defect by Gamache, Daniel A, Wei, Zhong-You, Weimer, Lori K, Miller, Steven T, Spellman, Joan M, Yanni, John M

“…The mucin secretagogue 15(S)-HETE was found to stimulate glycoprotein secretion in human ocular tissue at submicromolar concentrations in the present studies…”
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Improved myeloperoxidase assay for quantitation of neutrophil influx in a rat model of endotoxin-induced uveitis by Graff, Gustav, Gamache, Daniel A, Brady, Milton T, Spellman, Joan M, Yanni, John M

“…Previously described models of endotoxin-induced uveitis quantify neutrophil influx into the eye using biochemical or direct cell count methods that result in…”
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Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl)piperidines and structurally related compounds by Walsh, David A, Franzyshen, Stephen K, Yanni, John M

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Secretion of proinflammatory cytokines by human conjunctival epithelial cells by Gamache, Daniel A., Dimitrijevich, S. Dan, Weimer, Lori K., Lang, Laura S., Spellman, Joan M., Graff, Gustav, Yanni, John M.

“…The production of cytokines by human conjunctival epithelial cells following stimulation was investigated. Primary cultures of human conjunctival epithelial…”
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AL-2512, a novel corticosteroid: preclinical assessment of anti-inflammatory and ocular hypertensive effects by Bhattacherjee, Parimal, Mukhopadhyay, Partha, Paterson, Christopher A, Graff, Gustav, Gamache, Daniel A, Yanni, John M

“…The anti-inflammatory efficacy and ocular hypertensive effect of AL-2512 were characterized in rodent and feline models of ocular inflammation. Neutrophil…”
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Synthesis and substance P antagonist activity of naphthimidazolium derivatives by Lawrence, Kristine B, Venepalli, Bhaskar R, Appell, Kenneth C, Goswami, Ramanuj, Logan, Margaret E, Tomczuk, Bruce E, Yanni, John M

“…The synthesis of unsymmetrical naphth[2,3-d]imidazolium and bridged naphth[2,3-d]imidazolium derivatives and their substance P (SP) antagonist activity are…”
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Pharmacological validation of a feline model of steroid-induced ocular hypertension by Bhattacherjee, P, Paterson, C A, Spellman, J M, Graff, G, Yanni, J M

“…To validate pharmacologically the feline model of steroid-induced ocular hypertension. Serial studies were conducted in domesticated adult female cats trained…”
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Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists by Appell, Kenneth C, Babb, Bruce E, Goswami, Ramanuj, Hall, Patricia L, Lawrence Kristine B, Logan, Margaret E, Przyklek-Elling, Rose, Tomczuk, Bruce E, Venepalli, Bhaskar R, Yanni, John M

“…Substance P (SP) is an undecapeptide neuromodulator that belongs to the neurokinin (NK) family, which includes the structurally related neurokinin A (NKA) and…”
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Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives by Walsh, David A, Green, Jerry B, Franzyshen, Stephen K, Nolan, Joseph C, Yanni, John M

“…A series of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamides was synthesized and evaluated for antiallergy activity. Several derivatives had activity…”
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