Search Results - "Yanni, J M"

Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases by Sharif, N A, Xu, S X, Miller, S T, Gamache, D A, Yanni, J M

“…Olopatadine (AL-4943A; KW-4679) [(Z)-11-[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b,e]oxepine-2-acetic acid hydrochloride] is an…”
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Histamine-stimulated cytokine secretion from human conjunctival epithelial cells: inhibition by the histamine H1 antagonist emedastine by Weimer, L K, Gamache, D A, Yanni, J M

“…The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and…”
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The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent by Yanni, J M, Stephens, D J, Miller, S T, Weimer, L K, Graff, G, Parnell, D, Lang, L S, Spellman, J M, Brady, M T, Gamache, D A

“…Olopatadine (AL-4943A; KW-4679) [(z)-11-[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b,e]oxepine-2 acetic acid hydrochloride] is an anti-allergic agent…”
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Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cells by Yanni, J M, Miller, S T, Gamache, D A, Spellman, J M, Xu, S, Sharif, N A

“…The concept of mast cell heterogeneity is well established. Recent data indicate that human conjunctival tissue mast cells and human connective tissue mast…”
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Olopatadine (AL-4943A): ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis by Sharif, N A, Xu, S X, Yanni, J M

“…AL-4943A (Olopatadine) is a new antihistaminic and anti-allergic drug. It was tested for its ability to compete for [3H]pyrilamine, [3H]tiotidine and…”
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Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies by Sharif, N A, Su, S X, Yanni, J M

“…The antihistaminic agent, emedastine, was tested for its ability to compete for [3H]pyrilamine, [3H]tiotidine and [3H]N-methyl histamine binding to rodent…”
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Preclinical efficacy of emedastine, a potent, selective histamine H1 antagonist for topical ocular use by Yanni, J M, Stephens, D J, Parnell, D W, Spellman, J M

“…Emedastine [1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)- benzimidazole difumarate] was evaluated for topical ocular anti-histaminic activity in histamine…”
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Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs by Yanni, J M, Weimer, L K, Sharif, N A, Xu, S X, Gamache, D A, Spellman, J M

“…To evaluate the effects of topical ocular drugs with histamine H1-antagonist activity on histamine-stimulated phosphatidylinositol turnover and interleukin…”
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Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers by Ke, T L, Graff, G, Spellman, J M, Yanni, J M

“…Nepafenac, the amide analog of the NSAID amfenac, was examined in vitro for its bioactivation by ocular tissue components and its ability to permeate external…”
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Secretory response of mast cells contained in monodispersed human choroidal preparations by Miller, S T, Barney, N P, Gamache, D A, Spellman, J M, Yanni, J M

“…Mast cells have been identified in the choroid of numerous species including man. However, functional studies involving these human mast cells have not been…”
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Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy by Gamache, D A, Graff, G, Brady, M T, Spellman, J M, Yanni, J M

“…Nepafenac, the amide analog of 2-amino-3-benzoylbenzeneacetic acid (amfenac), was examined in preclinical models for its potential utility as a topical ocular…”
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Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds by WALSH, D. A, FRANZYSHEN, S. K, YANNI, J. M

“…A series of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines was synthesized and evaluated for antiallergy activity. Several analogues had potent…”
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Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac by Kapin, M A, Yanni, J M, Brady, M T, McDonough, T J, Flanagan, J G, Rawji, M H, Dahlin, D C, Sanders, M E, Gamache, D A

“…The purpose of this study was to evaluate the ability of the nonsteroidal anti-inflammatory drug nepafenac to prevent development of mitogen-induced…”
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Interactions of olopatadine and selected antihistamines with model and natural membranes by Brockman, Howard L., Momsen, Maureen M., Knudtson, Joshua R., Miller, Steven T., Graff, Gustav, Yanni, John M.

“…Objective: Olopatadine, an effective topical ocular human conjunctival mast cell stabilizer/antihistaminic antiallergic drug, was evaluated and compared to…”
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AHR-14310C: a potent, long-acting, nonsedating H1-antihistamine that prevents antigen-induced mucus formation in sensitive rats by Nolan, J C, Foxwell, M H, Whitman, L L, Yanni, J M, Walsh, D A, Kilpatrick, B F, Johnson, D N, Proakis, A G

“…AHR-14310C(5-[2-[4-[bis(4-fluorophenyl)hydroxymethyl- 1-piperidinyl]ethyl]-3-methyl]-2-oxazolidinone ethanedioate, hydrochloride salt) displays potent and…”
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Synthesis and substance P antagonist activity of naphthimidazolium derivatives by Lawrence, Kristine B, Venepalli, Bhaskar R, Appell, Kenneth C, Goswami, Ramanuj, Logan, Margaret E, Tomczuk, Bruce E, Yanni, John M

“…The synthesis of unsymmetrical naphth[2,3-d]imidazolium and bridged naphth[2,3-d]imidazolium derivatives and their substance P (SP) antagonist activity are…”
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Effects of AHR-5333, a new potential antiallergy compound, in in vivo models of immediate hypersensitivity by Yanni, J M, Foxwell, M H

“…AHR-5333 [1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl] propoxy]-3-methoxyphenyl]ethanone] possessed potent, long-acting activity in rat and…”
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Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists by Appell, Kenneth C, Babb, Bruce E, Goswami, Ramanuj, Hall, Patricia L, Lawrence Kristine B, Logan, Margaret E, Przyklek-Elling, Rose, Tomczuk, Bruce E, Venepalli, Bhaskar R, Yanni, John M

“…Substance P (SP) is an undecapeptide neuromodulator that belongs to the neurokinin (NK) family, which includes the structurally related neurokinin A (NKA) and…”
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Effect of antihistamines on antigen-induced increase of rat tracheal mucous gel layer thickness by Yanni, J M, Foxwell, M H, Whitman, L L

“…The effect of orally administered H1 and H2 antihistamines on antigen-induced changes in tracheal mucous gel layer thickness of actively sensitized rats was…”
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Preparation and characterization of monoclonal antibodies to substance P by Frickey, P H, Yanni, J M, Appell, K

“…A series of mouse hybridomas that produced monoclonal antibodies reactive with Substance P was prepared in an attempt to find a surrogate NK-1 receptor. When…”
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