Search Results - "Yannas, I. V."

Surface biology of collagen scaffold explains blocking of wound contraction and regeneration of skin and peripheral nerves by Yannas, I V, Tzeranis, D, So, P T

“…We review the details of preparation and of the recently elucidated mechanism of biological (regenerative) activity of a collagen scaffold (dermis regeneration…”
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Biologically active collagen-based scaffolds: advances in processing and characterization by Yannas, I. V., Tzeranis, D. S., Harley, B. A., So, P. T. C.

“…A small number of type I collagen-glycosaminoglycan scaffolds (collagen-GAG scaffolds; CGSs) have unusual biological activity consisting primarily in inducing…”
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Cellular materials as porous scaffolds for tissue engineering by Freyman, T.M., Yannas, I.V., Gibson, L.J.

“…A major goal of tissue engineering is to synthesize or regenerate tissues and organs. Today, this is done by providing a synthetic porous scaffold, or matrix,…”
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Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells by Song, Guodong, Nguyen, Dinh T., Pietramaggiori, Giorgio, Scherer, Saja, Chen, Bin, Zhan, Qian, Ogawa, Rei, Yannas, I.V., Wagers, Amy J., Orgill, Dennis P., Murphy, George F.

“…ABSTRACT Previous experimental studies to assess the contribution of blood‐borne circulating (BBC) cells to cutaneous wound healing have relied on…”
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Fibroblast contraction of a collagen–GAG matrix by Freyman, T.M., Yannas, I.V., Yokoo, R., Gibson, L.J.

“…Contractile cells, found in wounded or diseased tissues, are associated with the formation of scar tissue. The complexity of contraction in vivo has led to the…”
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Modeling the fabrication process of micropatterned macromolecular scaffolds for peripheral nerve regeneration by Sannino, A, Silvestri, L, Madaghiele, M, Harley, B, Yannas, I.V

“…Tubular scaffolds demonstrated to be able to reconnect the proximal and distal stumps of transected peripheral nerves and induce regeneration of the lost nerve…”
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Collagen-GAG Substrate Enhances the Quality of Nerve Regeneration through Collagen Tubes up to Level of Autograft by Chamberlain, L.J., Yannas, I.V., Hsu, H-P., Strichartz, G., Spector, M.

“…Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of…”
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Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model by Nehrer, S., Breinan, H.A., Ramappa, A., Hsu, H-P., Minas, T., Shortkroff, S., Sledge, C.B., Yannas, I.V., Spector, M.

“…The objective of our study was to evaluate reparative tissues formed in chondral defects in an adult canine model implanted with cultured autologous articular…”
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Inhibition of Conjunctival Scarring and Contraction by a Porous Collagen-Glycosaminoglycan Implant by Hsu, Wei-Cherng, Spilker, Mark H, Yannas, Ioannis V, Rubin, Peter A. D

“…To study the healing processes of full-thickness wounds in the adult rabbit conjunctiva after grafting with a porous collagen-glycosaminoglycan (CG) copolymer…”
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The effect of pore size on cell adhesion in collagen-GAG scaffolds by O’Brien, F.J., Harley, B.A., Yannas, I.V., Gibson, L.J.

“…The biological activity of scaffolds used in tissue engineering applications hypothetically depends on the density of available ligands, scaffold sites at…”
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Antigenicity and immunogenicity of collagen by Lynn, A.K., Yannas, I.V., Bonfield, W.

“…Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief…”
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Synthesis and Characterization of a Model Extracellular Matrix that Induces Partial Regeneration of Adult Mammalian Skin by Yannas, I. V., Lee, E., Orgill, D. P., Skrabut, E. M., Murphy, G. F.

“…Regeneration of the dermis does not occur spontaneously in the adult mammal. The epidermis is regenerated spontaneously provided there is a dermal substrate…”
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Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices by Samuel, R E, Lee, C R, Ghivizzani, S C, Evans, C H, Yannas, I V, Olsen, B R, Spector, M

“…Our primary objective was to fabricate a porous gene-supplemented collagen-glycosaminoglycan (GSCG) matrix for sustained delivery (over a period of several…”
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Organized Skin Structure Is Regenerated In Vivo from Collagen-GAG Matrices Seeded with Autologous Keratinocytes by Compton, Carolyn C., Butler, Charles E., Yannas, Ioannis V., Warland, Gretchen, Orgill, Dennis P.

“…A well-characterized collagen-glycosaminoglycan matrix (CGM) that has been shown to function as a dermal analog was seeded with freshly disaggregated…”
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Early peripheral nerve healing in collagen and silicone tube implants: Myofibroblasts and the cellular response by Chamberlain, L.J., Yannas, I.V., Arrizabalaga, A., Hsu, H.-P., Norregaard, T.V., Spector, M.

“…Injuries to peripheral nerves innervating a limb cause paralysis, and can necessitate amputation. The inability of the nerves to regenerate spontaneously and…”
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The effects of tubulation on healing and scar formation after transection of the adult rat spinal cord by Spilker, M H, Yannas, I V, Kostyk, S K, Norregaard, T V, Hsu, H P, Spector, M

“…The purpose of this study was to characterize the effects of implantation of a collagen tube on healing and scar formation following transection of tbc adult…”
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Vascularized Collagen-Glycosaminoglycan Matrix Provides a Dermal Substrate and Improves Take of Cultured Epithelial Autografts by Orgill, Dennis P, Butler, Charles, Regan, John F, Barlow, Mark S, Yannas, I V, Compton, Carolyn C

“…Cultured epithelial autografts are an important adjunct in treating severely burned patients, greatly expanding the epidermis using a small donor site…”
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Degradation of a collagen–chondroitin-6-sulfate matrix by collagenase and by chondroitinase by Pek, Y.S., Spector, M., Yannas, I.V., Gibson, L.J.

“…Highly porous, type I collagen–chondroitin-6-sulfate (collagen–GAG) scaffolds, produced by freeze-drying techniques, have proven to be of value as implants to…”
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Tensional homeostasis in dermal fibroblasts: Mechanical responses to mechanical loading in three-dimensional substrates by Brown, R. A., Prajapati, R., McGrouther, D. A., Yannas, I. V., Eastwood, M.

“…Many soft connective tissues are under endogenous tension, and their resident cells generate considerable contractile forces on the extracellular matrix. The…”
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Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes by Nehrer, Stefan, Breinan, Howard A., Ramappa, Arun, Young, Gretchen, Shortkroff, Sonya, Louie, Libby K., Sledge, Clement B., Yannas, Ioannis V., Spector, Myron

“…This study directly compared the behaviour of chondrocytes in porous matrices comprising different collagen types and different pore diameters. There was a…”
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