Synthesis of some novel isoxazolidine derivatives via 1,3-dipolar cycloaddition and their biological evaluation
A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reactions of α-aryl-N-methyl nitrones with diethyl maleate. The structures of the synthesized compounds were characterized using spectroscopic methods. All the synthesized compounds were screened fo...
Saved in:
| Published in: | Gazi University Journal of Science Vol. 32; no. 1; pp. 78 - 89 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Gazi Üniversitesi Yayınları
01-01-2019
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reactions of α-aryl-N-methyl nitrones with diethyl maleate. The structures of the synthesized compounds were characterized using spectroscopic methods. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against a yeast strain. The results show that all the synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs. |
|---|---|
| ISSN: | 2147-1762 |