Search Results - "Yankova, Eliza"

Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies by Han, Namshik, Hwang, Woochang, Tzelepis, Konstantinos, Schmerer, Patrick, Yankova, Eliza, MacMahon, Méabh, Lei, Winnie, M Katritsis, Nicholas, Liu, Anika, Felgenhauer, Ulrike, Schuldt, Alison, Harris, Rebecca, Chapman, Kathryn, McCaughan, Frank, Weber, Friedemann, Kouzarides, Tony

“…The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates the rapid development of new therapies against coronavirus…”
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P1334: THE IMPACT OF SMALL MOLECULE INHIBITION OF METTL3 ON NORMAL HAEMATOPOIESIS by Sturgess, Katherine, Vijayabaskar, Ms, Yankova, Eliza, Rak, Justyna, Eleftheriou, Maria, Isobe, Tomoya, Barile, Melania, Gozdecka, Malgorzata, Gottgens, Berthold, Wilson, Nicola, Tzelepis, Kostas

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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia by Yankova, Eliza, Blackaby, Wesley, Albertella, Mark, Rak, Justyna, De Braekeleer, Etienne, Tsagkogeorga, Georgia, Pilka, Ewa S., Aspris, Demetrios, Leggate, Dan, Hendrick, Alan G., Webster, Natalie A., Andrews, Byron, Fosbeary, Richard, Guest, Patrick, Irigoyen, Nerea, Eleftheriou, Maria, Gozdecka, Malgorzata, Dias, Joao M. L., Bannister, Andrew J., Vick, Binje, Jeremias, Irmela, Vassiliou, George S., Rausch, Oliver, Tzelepis, Konstantinos, Kouzarides, Tony

“…N 6 -methyladenosine (m 6 A) is an abundant internal RNA modification 1 , 2 that is catalysed predominantly by the METTL3–METTL14 methyltransferase complex 3 ,…”
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The m6A RNA modification in AML by Yankova, Eliza, Aspris, Demetrios, Tzelepis, Konstantinos

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The N6-methyladenosine RNA modification in acute myeloid leukemia by Yankova, Eliza, Aspris, Demetrios, Tzelepis, Konstantinos

“…In recent years, the N6-methyladenosine (m6A) modification of RNA has been shown to play an important role in the development of acute myeloid leukemia (AML)…”
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The N6-methyladenosine RNA modification in acute myeloid leukemia by Yankova, Eliza, Aspris, Demetrios, Tzelepis, Konstantinos

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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation by Orellana, Esteban A., Liu, Qi, Yankova, Eliza, Pirouz, Mehdi, De Braekeleer, Etienne, Zhang, Wencai, Lim, Jihoon, Aspris, Demetrios, Sendinc, Erdem, Garyfallos, Dimitrios A., Gu, Muxin, Ali, Raja, Gutierrez, Alejandro, Mikutis, Sigitas, Bernardes, Gonçalo J.L., Fischer, Eric S., Bradley, Allan, Vassiliou, George S., Slack, Frank J., Tzelepis, Konstantinos, Gregory, Richard I.

“…The emerging “epitranscriptomics” field is providing insights into the biological and pathological roles of different RNA modifications. The RNA…”
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Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages by Sturgess, Katherine, Yankova, Eliza, Vijayabaskar, M. S., Isobe, Tomoya, Rak, Justyna, Kucinski, Iwo, Barile, Melania, Webster, Natalie A., Eleftheriou, Maria, Hannah, Rebecca, Gozdecka, Malgorzata, Vassiliou, George, Rausch, Oliver, Wilson, Nicola K., Göttgens, Berthold, Tzelepis, Konstantinos

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Strains of the Propionibacterium acnes type III lineage are associated with the skin condition progressive macular hypomelanosis by Barnard, Emma, Liu, Jared, Yankova, Eliza, Cavalcanti, Silvana M., Magalhães, Marcelo, Li, Huiying, Patrick, Sheila, McDowell, Andrew

“…Progressive macular hypomelanosis (PMH) is a common skin disorder that causes hypopigmentation in a variety of skin types. Although the underlying aetiology of…”
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Abstract B126: A small molecule inhibitor of the RNA m6A writer METTL3 inhibits the development of acute myeloid leukemia (AML) in vivo by Albertella, Mark, Blackaby, Wesley, Fosbeary, Richard, Hendrick, Alan, Leggate, Dan, Ofir-Rosenfeld, Yaara, Sapetschnig, Alexandra, Tzelepis, Konstantinos, Yankova, Eliza, Kouzarides, Tony, Rausch, Oliver

“…Abstract METTL3 is an RNA methyltransferase which is responsible for the deposition of N-6-methyladenosine (m6A) on mRNA targets such as SP1, to modulate their…”
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Pharmacological Inhibition of the RNA m6a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia by Tzelepis, Konstantinos, De Braekeleer, Etienne, Yankova, Eliza, Rak, Justyna, Aspris, Demetrios, Domingues, Ana Filipa, Fosbeary, Richard, Hendrick, Alan, Leggate, Dan, Ofir-Rosenfeld, Yaara, Sapetschnig, Alexandra, Pina, Cristina, Albertella, Mark, Blackaby, Wesley, Rausch, Oliver, Vassiliou, George S., Kouzarides, Tony

“…Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which the therapeutic landscape has changed little for decades. New evidence…”
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Abstract LB171: First-in-class inhibitors of the tRNA methyltransferase METTL1 for the treatment of cancer by Sapetschnig, Alexandra, Thomas, Beth, Yankova, Eliza, Fischl, Harry, Azevedo, Aleksandra, Bucknell, Sarah, Fosbeary, Richard, Sawyer, Sapphire, Evans, Sian, Livi, Carmen, Andrews, Byron, Rogan, Jack, Webster, Natalie, Fyfe, Matthew, Tzelepis, Konstantinos, Rausch, Oliver

“…Abstract METTL1 is an RNA methyltransferase that catalyzes N7-methylation on guanine at position 46 (m7G46) in a subset of transfer RNAs (tRNAs). These tRNAs…”
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Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules by Mikutis, Sigitas, Rebelo, Maria, Yankova, Eliza, Gu, Muxin, Tang, Cong, Coelho, Ana R., Yang, Mo, Hazemi, Madoka E., Pires de Miranda, Marta, Eleftheriou, Maria, Robertson, Max, Vassiliou, George S., Adams, David J., Simas, J. Pedro, Corzana, Francisco, Schneekloth, John S., Tzelepis, Konstantinos, Bernardes, Gonçalo J. L.

“…Nature has evolved intricate machinery to target and degrade RNA, and some of these molecular mechanisms can be adapted for therapeutic use. Small interfering…”
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METTL1-mediated m 7 G modification of Arg-TCT tRNA drives oncogenic transformation by Orellana, Esteban A, Liu, Qi, Yankova, Eliza, Pirouz, Mehdi, De Braekeleer, Etienne, Zhang, Wencai, Lim, Jihoon, Aspris, Demetrios, Sendinc, Erdem, Garyfallos, Dimitrios A, Gu, Muxin, Ali, Raja, Gutierrez, Alejandro, Mikutis, Sigitas, Bernardes, Gonçalo J L, Fischer, Eric S, Bradley, Allan, Vassiliou, George S, Slack, Frank J, Tzelepis, Konstantinos, Gregory, Richard I

“…The emerging "epitranscriptomics" field is providing insights into the biological and pathological roles of different RNA modifications. The RNA…”
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