Search Results - "Yang, Zhen Fan"

EGFR L792H and G796R: Two Novel Mutations Mediating Resistance to the Third-Generation EGFR Tyrosine Kinase Inhibitor Osimertinib by Zhang, Qi, Zhang, Xu-Chao, Yang, Jin-Ji, Yang, Zhen-Fan, Bai, Yu, Su, Jian, Wang, Zheng, Zhang, Zhou, Shao, Yang, Zhou, Qing, Kang, Jin, Ke, E-E, Zhang, Yi-Chen, Dong, Zhong-Yi, Chen, Zhi-Hong, Tu, Hai-Yan, Zhong, Wen-Zhao, Yang, Xue-Ning, Wu, Yi-Long

“…The third-generation EGFR tyrosine kinase inhibitor osimertinib has been approved in many countries to treat advanced NSCLC in patients with the EGFR T790M…”
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Identification of local and circulating cancer stem cells in human liver cancer by Yang, Zhen Fan, Ngai, Patricia, Ho, David W., Yu, Wan Ching, Ng, Michael N.P., Lau, Chi Keung, Li, Mandy L. Y., Tam, Ka Ho, Lam, Chi Tat, Poon, Ronnie T. P., Fan, Sheung Tat

“…Increasing evidence has revealed the importance of cancer stem cells (CSCs) in carcinogenesis. Although liver CSCs have been identified in hepatocellular…”
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An Akt/Hypoxia-inducible Factor-1α/Platelet-Derived Growth Factor-BB Autocrine Loop Mediates Hypoxia-induced Chemoresistance in Liver Cancer Cells and Tumorigenic Hepatic Progenitor Cells by CHI KEUNG LAU, ZHEN FAN YANG, HO, David W, NG, Michael N, YEOH, George C. T, POON, Ronnie T. P, SHEUNG TAT FAN

“…Abstract Purpose: The goals of the present study were to investigate the mechanism of hypoxia-mediated chemoresistance in liver cancer cells and tumorigenic…”
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Brain-Derived Neurotrophic Factor Promotes Tumorigenesis via Induction of Neovascularization: Implication in Hepatocellular Carcinoma by LAM, Chi-Tat, YANG, Zhen-Fan, LAU, Chi-Keung, TAM, Ka-Ho, FAN, Sheung-Tat, POON, Ronnie T. P

“…Brain-derived neurotrophic factor (BDNF) has emerged as a novel angiogenic factor, and yet its impact on tumorigenesis is unclear. This study aimed at…”
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Tumor Microvessel Density as a Predictor of Recurrence After Resection of Hepatocellular Carcinoma: A Prospective Study by POON, Ronnie Tung-Ping, NG, Irene Oi-Lin, LAU, Cecilia, YU, Wun-Ching, YANG, Zhen-Fan, FAN, Sheung-Tat, WONG, John

“…This study prospectively evaluated the correlation of tumor microvessel density (MVD) with clinicopathologic features and postoperative recurrence in patients…”
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Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages by Yang, Zhen Fan, Ho, David W., Lau, Chi Keung, Lam, Chi Tat, Lum, Ching Tung, Poon, Ronnie T. P., Fan, Sheung Tat

“…Our previous studies revealed that macrophages played an important role in linking injury, inflammatory and immune response in small-for-size liver…”
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Role of stem cells in normal liver and cancer by Lau, Chi Keung, Yang, Zhen Fan, Fan, Sheung Tat

“…Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world because current treatments, including both surgical and…”
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Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma by Lau, Chi Keung, Yang, Zhen Fan, Lam, Shuk Pik, Lam, Chi Tat, Ngai, Patricia, Tam, Ka Ho, Poon, Ronnie Tung-Ping, Fan, Sheung-Tat

“…The present study investigated the effect of YC-1, a novel anti-cancer agent, on the chemo-sensitivity of hepatocellular carcinoma (HCC). YC-1 was administered…”
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Rac Activation Is Associated with Hepatocellular Carcinoma Metastasis by Up-regulation of Vascular Endothelial Growth Factor Expression by Lee, Terence K, Poon, Ronnie T P, Yuen, Anthony P, Man, Kwan, Yang, Zhen Fan, Guan, Xin Yuan, Fan, Sheung Tat

“…Purpose: Hepatocellular carcinoma (HCC) is associated with a propensity for vascular invasion and metastasis, which contribute to poor prognosis. Angiogenesis…”
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Significance of CD90 + Cancer Stem Cells in Human Liver Cancer by Yang, Zhen Fan, Ho, David W., Ng, Michael N., Lau, Chi Keung, Yu, Wan Ching, Ngai, Patricia, Chu, Patrick W.K., Lam, Chi Tat, Poon, Ronnie T.P., Fan, Sheung Tat

“…This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90 + cells, but not…”
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Surface‐enhanced laser desorption/ionization time‐of‐flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma by Wing Yuen Ho, David, Fan Yang, Zhen, Yee‐Hang Wong, Birgitta, Lai‐Wan Kwong, Dora, Shun‐Tong Sham, Jonathan, Ignace Wei, William, Po Wing Yuen, Anthony

“…BACKGROUND Diagnosis of nasopharyngeal carcinoma (NPC) at an early disease stage is important for successful treatment and improving the outcome of patients…”
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The Kringle 1 Domain of Hepatocyte Growth Factor Has Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma by ZAN SHEN, ZHEN FAN YANG, TSAI PING LI, REN BAO GAN, MING LIANG HE, HSIANG FU KUNG, LIN, Marie C. M, YI GAO, JI CHENG LI, HAI XIAO CHEN, CHING CHIN LIU, POON, Ronnie T. P, SHEUNG TAT FAN, LUK, John M, KONG HUNG SZE

“…The kringle 1 domain of human hepatocyte growth factor (HGFK1) was previously shown to inhibit bovine aortic endothelial cell proliferation, suggesting that it…”
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Linking Inflammation to Acute Rejection in Small‐For‐Size Liver Allografts: The Potential Role of Early Macrophage Activation by Yang, Zhen‐Fan, Ho, David Wing‐Yuen, Chu, Andrew Chi‐Yuen, Wang, Yan‐Qing, Fan, Sheung‐Tat

“…This study aims to investigate the immunological status of small‐for‐size liver allografts and possible mechanism that contributes to the accelerated immune…”
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Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4–AKT–ATP‐binding cassette G2 pathway by Wang, Xiao Qi, Ongkeko, Weg M., Chen, Lin, Yang, Zhen Fan, Lu, Ping, Chen, Kwok Kin, Lopez, Jay P., Poon, Ronnie T.P., Fan, Sheung Tat

“…Chemoresistance presents a major obstacle to the efficacy of chemotherapeutic treatment of cancers. Using chemotherapeutic drugs to select drug‐resistant…”
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Prediction of Posthepatectomy Recurrence of Hepatocellular Carcinoma by Circulating Cancer Stem Cells: A Prospective Study by SHEUNG TAT FAN, ZHEN FAN YANG, HO, David WY, NG, Vlichael N. P, WAN CHING YU, WONG, John

“…To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy. HCC recurrence…”
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Vascular Changes in Hepatocellular Carcinoma by Yang, Zhen Fan, Poon, Ronnie T.P.

“…Hepatocellular carcinoma (HCC) is one of the most vascular solid tumors, in which angiogenesis plays an important role. The status of angiogenesis in HCC…”
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Gene expression profiling of liver cancer stem cells by RNA-sequencing by Ho, David W Y, Yang, Zhen Fan, Yi, Kang, Lam, Chi Tat, Ng, Michael N P, Yu, Wan Ching, Lau, Joyce, Wan, Timothy, Wang, Xiaoqi, Yan, Zhixiang, Liu, Hang, Zhang, Yong, Fan, Sheung Tat

“…Accumulating evidence supports that tumor growth and cancer relapse are driven by cancer stem cells. Our previous work has demonstrated the existence of…”
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Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liver by Wang, Xiao Qi, Lo, Chung Mau, Chen, Lin, Cheung, Cindy K.Y., Yang, Zhen Fan, Chen, Yong Xiong, Ng, Michael N., Yu, Wan Ching, Ming, Xiaoyan, Zhang, Wu, Ho, David W.Y., Chan, See Ching, Fan, Sheung Tat

“…Liver transplantation (LT) is a cure for many liver diseases. Blood chimerism of donor origin can develop after LT, which raises the possibility of the…”
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Inhibition of mTOR enhances chemosensitivity in hepatocellular carcinoma by Tam, Ka Ho, Yang, Zhen Fan, Lau, Chi Keung, Lam, Chi Tat, Pang, Roberta W.C, Poon, Ronnie T.P

“…Abstract The present study investigated the effect of mammalian target of rapamycin (mTOR) inhibition on HCC cells in vitro and in vivo , either alone or in…”
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Intracerebral hemorrhage after liver transplantation by Wang, Wei‐Lin, Yang, Zhen‐Fan, Lo, Chung‐Mau, Liu, Chi‐Leung, Fan, Sheung‐Tat

“…We report 5 patients with intracerebral hemorrhage after orthotopic liver transplantation (OLT) and identify the possible risk factors. Between November 1991…”
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