Search Results - "Yang, Yemen"

Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein by Ashraf, Naila S., Sutton, Joanna R., Yang, Yemen, Ranxhi, Bedri, Libohova, Kozeta, Shaw, Emily D., Barget, Anna J., Todi, Sokol V., Paulson, Henry L., Costa, Maria do Carmo

“…Spinocerebellar Ataxia type 3 (SCA3, also known as Machado-Joseph disease) is a neurodegenerative disorder caused by a CAG repeat expansion encoding an…”
Get full text

Metabolic Crosstalk: Molecular Links Between Glycogen and Lipid Metabolism in Obesity by BINBIN LU, BRIDGES, Dave, LIDDLE, Christopher, EVANS, Ronald M, SALTIEL, Alan R, YEMEN YANG, FISHER, Kaleigh, CHENG, Alan, CHANG, Louise, MENG, Zhuo-Xian, LIN, Jiandie D, DOWNES, Michael, YU, Ruth T

“…Glycogen and lipids are major storage forms of energy that are tightly regulated by hormones and metabolic signals. We demonstrate that feeding mice a high-fat…”
Get full text

Toward RNAi Therapy for the Polyglutamine Disease Machado–Joseph Disease by do Carmo Costa, Maria, Luna-Cancalon, Katiuska, Fischer, Svetlana, Ashraf, Naila S, Ouyang, Michelle, Dharia, Rahil M, Martin-Fishman, Lucas, Yang, Yemen, Shakkottai, Vikram G, Davidson, Beverly L, Rodríguez-Lebrón, Edgardo, Paulson, Henry L

“…Machado–Joseph disease (MJD) is a dominantly inherited ataxia caused by a polyglutamine-coding expansion in the ATXN3 gene. Suppressing expression of the toxic…”
Get full text

Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3 by Costa, Maria do Carmo, Ashraf, Naila S, Fischer, Svetlana, Yang, Yemen, Schapka, Emily, Joshi, Gnanada, McQuade, Thomas J, Dharia, Rahil M, Dulchavsky, Mark, Ouyang, Michelle, Cook, David, Sun, Duxin, Larsen, Martha J, Gestwicki, Jason E, Todi, Sokol V, Ivanova, Magdalena I, Paulson, Henry L

“…No disease-modifying treatment exists for the fatal neurodegenerative polyglutamine disease known both as Machado-Joseph disease and spinocerebellar ataxia…”
Get full text