Search Results - "Yang, Xuexian O"

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib by Wu, Dandan, Yang, Xuexian O.

“…COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in…”
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Dysregulation of Pulmonary Responses in Severe COVID-19 by Wu, Dandan, Yang, Xuexian O.

“…Patients with coronavirus disease 2019 (COVID-19) predominantly have a respiratory tract infection with various symptoms and high mortality is associated with…”
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Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling by Chung, Yeonseok, Chang, Seon Hee, Martinez, Gustavo J., Yang, Xuexian O., Nurieva, Roza, Kang, Hong Soon, Ma, Li, Watowich, Stephanie S., Jetten, Anton M., Tian, Qiang, Dong, Chen

“…T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is critically…”
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Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease by Zheng, Handong, Zhang, Xing, Castillo, Eliseo F, Luo, Yan, Liu, Meilian, Yang, Xuexian O

“…Allergic asthma and obesity are the leading health problems in the world. Many studies have shown that obesity is a risk factor of development of asthma…”
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STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells by Yang, Xuexian O., Panopoulos, Athanasia D., Nurieva, Roza, Chang, Seon Hee, Wang, Demin, Watowich, Stephanie S., Dong, Chen

“…Interleukin-17 (IL-17)-producing helper T (TH) cells, named as THIL-17, TH17, or inflammatory TH (THi), have been recently identified as a novel effector…”
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Regulation of inflammatory responses by IL-17F by Yang, Xuexian O, Chang, Seon Hee, Park, Heon, Nurieva, Roza, Shah, Bhavin, Acero, Luis, Wang, Yi-Hong, Schluns, Kimberly S, Broaddus, Russell R, Zhu, Zhou, Dong, Chen

“…Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which has an expression pattern regulated similarly to IL-17, is…”
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Chromatin Remodeling of Interleukin-17 (IL-17)-IL-17F Cytokine Gene Locus during Inflammatory Helper T Cell Differentiation by Akimzhanov, Askar M., Yang, Xuexian O, Dong, Chen

“…During differentiation of naive CD4+ helper T (TH) cells into effector cells, specific cytokine gene loci undergo extensive changes in chromatin modification…”
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Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells by Merkley, Seth D, Chock, Cameron J, Yang, Xuexian O, Harris, James, Castillo, Eliseo F

“…Autophagy is a homeostatic and inducible process affecting multiple aspects of the immune system. This intrinsic cellular process is involved in MHC-antigen…”
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Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway by Zheng, Handong, Wu, Dandan, Wu, Xiang, Zhang, Xing, Zhou, Qin, Luo, Yan, Yang, Xin, Chock, Cameron J., Liu, Meilian, Yang, Xuexian O.

“…Allergic asthma and obesity are major public health problems in the world. Recent Meta-analysis studies implicated a positive relationship between serum…”
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Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway by Zhang, Xing, Luo, Yan, Wang, Chunqing, Ding, Xiaofeng, Yang, Xin, Wu, Dandan, Silva, Floyd, Yang, Zijiang, Zhou, Qin, Wang, Lu, Wang, Xiaoqing, Zhou, Jianlin, Boyd, Nathan, Spafford, Michael, Burge, Mark, Yang, Xuexian O., Liu, Meilian

“…Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity…”
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Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation by Su, Yang, Huang, Jinling, Zhao, Xiaohong, Lu, Huiping, Wang, Wang, Yang, Xuexian O, Shi, Yuling, Wang, Xiaohu, Lai, Yuping, Dong, Chen

“…T helper 17 (T 17) cells and interleukin-17A (IL-17A) produced by them are critical in autoinflammatory diseases, such as psoriasis. IL-17A has been shown to…”
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Regulation and Function of Proinflammatory TH17 Cells by Martinez, Gustavo J., Nurieva, Roza I., Yang, Xuexian O., Dong, Chen

“…Naïve CD4+ helper T (TH) cells, upon activation by antigen‐presenting cells (APC), differentiate into different types of effector cells that are characterized…”
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A protective role by interleukin-17F in colon tumorigenesis by Tong, Zan, Yang, Xuexian O, Yan, Huichao, Liu, Weihuang, Niu, Xiaoyin, Shi, Yun, Fang, Wenfeng, Xiong, Bing, Wan, Yu, Dong, Chen

“…Interleukin-17F (IL-17F), produced by Th17 cells and other immune cells, is a member of IL-17 cytokine family with highest homology to IL-17A. IL-17F has been…”
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Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2 by Wang, Xiaohu, Zhang, Yibing, Yang, Xuexian O., Nurieva, Roza I., Chang, Seon Hee, Ojeda, Sandra S., Kang, Hong S., Schluns, Kimberly S., Gui, Jianfang, Jetten, Anton M., Dong, Chen

“…T helper 17 (Th17) cells specifically transcribe the Il17 and Il17f genes, which are localized in the same chromosome region, but the underlying mechanism is…”
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RORα is critical for mTORC1 activity in T cell-mediated colitis by Chi, Xinxin, Jin, Wei, Bai, Xue, Zhao, Xiaohong, Shao, Jing, Li, Jiaqi, Sun, Qinli, Su, Bing, Wang, Xiaohu, Yang, Xuexian O., Dong, Chen

“…Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells, among which a large portion of patients are…”
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IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation by Peng, Juan, Yang, Xuexian O, Chang, Seon Hee, Yang, Jiong, Dong, Chen

“…IL-23/IL-17 axis is an important regulator in various inflammatory diseases. However, the role of IL-23 in allergic airway inflammation is not well understood…”
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Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients by Coleman, Mia, Zimmerly, Kourtney, Yang, Xuexian

“…Coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes infectious disease, and manifests in a wide range of…”
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Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment by Yang, Xuexian O, Angkasekwinai, Pornpimon, Zhu, Jinfang, Peng, Juan, Liu, Zhiduo, Nurieva, Roza, Liu, Xikui, Chung, Yeonseok, Chang, Seon Hee, Sun, Bing, Dong, Chen

“…The molecular mediators responsible for directing T helper type 2 (T H 2) differentiation remain incompletely defined. Dong and co-workers find that the…”
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COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity by Wang, Chunqing, Zhang, Xing, Luo, Liping, Luo, Yan, Wu, Dandan, Spilca, Dianna, Le, Que, Yang, Xin, Alvarez, Katelyn, Hines, William Curtis, Yang, Xuexian O, Liu, Meilian

“…Cyclooxygenase-2 (COX-2) plays a critical role in regulating innate immunity and metabolism by producing prostaglandins (PGs) and other lipid mediators…”
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Longitudinal Assessment of Cytokine Expression and Plasminogen Activation in Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction in End-Stage Disease by Simons, Peter, Guo, Yan, Bondu, Virginie, Tigert, Susan L, Harkins, Michelle, Goodfellow, Samuel, Tompkins, Cana, Chabot-Richards, Devon, Yang, Xuexian O, Bosc, Laura Gonzalez, Bradfute, Steven, Lawrence, Daniel A, Buranda, Tione

“…Pathogenic New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS), a severe immunopathogenic disease in humans manifested by pulmonary…”
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