Search Results - "Yang, Xinqun"

Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma by Stewart, A. Keith, Rajkumar, S. Vincent, Dimopoulos, Meletios A, Masszi, Tamás, Špička, Ivan, Oriol, Albert, Hájek, Roman, Rosiñol, Laura, Siegel, David S, Mihaylov, Georgi G, Goranova-Marinova, Vesselina, Rajnics, Péter, Suvorov, Aleksandr, Niesvizky, Ruben, Jakubowiak, Andrzej J, San-Miguel, Jesus F, Ludwig, Heinz, Wang, Michael, Maisnar, Vladimír, Minarik, Jiri, Bensinger, William I, Mateos, Maria-Victoria, Ben-Yehuda, Dina, Kukreti, Vishal, Zojwalla, Naseem, Tonda, Margaret E, Yang, Xinqun, Xing, Biao, Moreau, Philippe, Palumbo, Antonio

“…In this study, the addition of carfilzomib to lenalidomide and dexamethasone improved response rates and overall survival among patients with relapsed multiple…”
Get full text

Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung Cancer by Soria, Jean-Charles, Smit, Egbert, Khayat, David, Besse, Benjamin, Yang, Xinqun, Hsu, Cheng-Pang, Reese, David, Wiezorek, Jeffrey, Blackhall, Fiona

“…To determine the safety, pharmacokinetics (PK), and maximum-tolerated dose (MTD) up to a prespecified target dose of dulanermin in combination with paclitaxel,…”
Get full text

A phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma by Schöffski, Patrick, Garcia, Jorge A., Stadler, Walter M., Gil, Thierry, Jonasch, Eric, Tagawa, Scott T., Smitt, Melanie, Yang, Xinqun, Oliner, Kelly S., Anderson, Abraham, Zhu, Min, Kabbinavar, Fairooz

“…Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does the study add? It is now recognized that all patients with…”
Get full text

Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A by Ozelo, Margareth C, Mahlangu, Johnny, Pasi, K. John, Giermasz, Adam, Leavitt, Andrew D, Laffan, Michael, Symington, Emily, Quon, Doris V, Wang, Jiaan-Der, Peerlinck, Kathelijne, Pipe, Steven W, Madan, Bella, Key, Nigel S, Pierce, Glenn F, O’Mahony, Brian, Kaczmarek, Radoslaw, Henshaw, Joshua, Lawal, Adebayo, Jayaram, Kala, Huang, Mei, Yang, Xinqun, Wong, Wing Y, Kim, Benjamin

“…Patients with severe hemophilia A were treated with an adenoviral construct containing coagulation factor VIII cDNA and followed for 1 to 3 years. Median…”
Get full text

Invasiveness and MMP Expression in Pancreatic Carcinoma by Yang, Xinqun, Staren, Edgar D., Howard, John M., Iwamura, Takeshi, Bartsch, John E., Appert, Hubert E.

“…Background. Previous investigations have suggested that expression of matrix metalloproteinases (MMPs) may be related to increased invasiveness of various…”
Get full text

Persistence of haemostatic response following gene therapy with valoctocogene roxaparvovec in severe haemophilia A by Pasi, K John, Laffan, Michael, Rangarajan, Savita, Robinson, Tara M, Mitchell, Nina, Lester, Will, Symington, Emily, Madan, Bella, Yang, Xinqun, Kim, Benjamin, Pierce, Glenn F, Wong, Wing Yen

“…Introduction Valoctocogene roxaparvovec is an investigational AAV5‐based factor VIII (FVIII) gene therapy that has demonstrated sustained clinical benefit in…”
Get full text

Health-Related Quality-of-Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With Relapsed Multiple Myeloma by Stewart, A Keith, Dimopoulos, Meletios A, Masszi, Tamás, Špička, Ivan, Oriol, Albert, Hájek, Roman, Rosiñol, Laura, Siegel, David S, Niesvizky, Ruben, Jakubowiak, Andrzej J, San-Miguel, Jesus F, Ludwig, Heinz, Buchanan, Jacqui, Cocks, Kim, Yang, Xinqun, Xing, Biao, Zojwalla, Naseem, Tonda, Margaret, Moreau, Philippe, Palumbo, Antonio

“…Purpose To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of…”
Get full text

Comparative Effectiveness of Valoctocogene Roxaparvovec and Prophylactic Factor VIII Replacement in Severe Hemophilia A by Oldenburg, Johannes, Chambost, Herve, Liu, Hai, Hawes, Charles, You, Xiaojun, Yang, Xinqun, Newman, Vanessa, Robinson, Tara M., Hatswell, Anthony J., Hinds, David, Santos, Sandra, Ozelo, Margareth

“…Introduction A prospective, non-interventional study (270-902) followed 294 adults with severe hemophilia A (SHA) receiving prophylactic factor VIII (FVIII)…”
Get full text

Phase Ib study of AMG 386 in combination with paclitaxel (P) and carboplatin (C) in high-risk stage I and stages II-IV epithelial ovarian, primary peritoneal, or fallopian tube cancers by Casado, Antonio, Oaknin, Ana, Baurain, Jean-Francois, Wong, Shirley S., Yang, Xinqun, Wu, Benjamin, Zhong, Zhandong Don, Puhlmann, Markus, Vergote, Ignace B.

“…Abstract only 5038 Background: AMG 386 is a first-in-class investigational peptibody that inhibits angiopoietin-1/-2 binding to Tie2. We report on an ongoing,…”
Get full text

An Open-Label Clinical Trial Evaluating Safety and Pharmacokinetics of Two Dosing Schedules of Panitumumab in Patients with Solid Tumors by Stephenson, Joe J, Gregory, Charles, Burris, Howard, Larson, Tim, Verma, Udit, Cohn, Allen, Crawford, Jeffrey, Cohen, Roger B, Martin, Julie, Lum, Peggy, Yang, Xinqun, Amado, Rafael G

“…Abstract Purpose This study evaluated safety, pharmacokinetics, and efficacy of 2 dose schedules and 2 infusion times of panitumumab in patients with advanced…”
Get full text

The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker by Yang, Xinqun, Huang, Jian, Logue, Mark W, Vieland, Veronica J

“…The posterior probability of linkage (PPL) statistic has been developed as a method for the rigorous accumulation of evidence for or against linkage allowing…”
Get more information

The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker by Yang, Xinqun

“…In previous work, we have developed a Bayesian approach to linkage analysis based on the posterior probability of linkage (PPL). To date, however, the method…”
Get full text

The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker by Yang, Xinqun

“…In previous work, we have developed a Bayesian approach to linkage analysis based on the posterior probability of linkage (PPL). To date, however, the method…”
Get full text

Invasiveness and regulation of MMP-2 and MMP-9 expression in pancreatic tumor cell line SUIT-2 and its sublines by Yang, Xinqun

“…Previous investigations have suggested that expression of matrix metalloproteinases (MMPs) may be related to increased invasiveness of various tumors. This…”
Get full text

Genome-wide linkage analysis of blood pressure under locus heterogeneity by Yang, Xinqun, Wang, Kai, Huang, Jian, Vieland, Veronica J

“…We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed…”
Get full text