Search Results - "Yang, Xiangliang"
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Photoactivatable Protherapeutic Nanomedicine for Cancer
Published in Advanced materials (Weinheim) (01-08-2020)“…Therapeutic systems with site‐specific pharmaceutical activation hold great promise to enhance therapeutic efficacy while reducing systemic toxicity in cancer…”
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2
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts
Published in Nature communications (19-05-2022)“…Insufficient tumor accumulation and distribution of photosensitizers as well as low antitumor immunity severely restrict the therapeutic efficacy of…”
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3
Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
Published in Nature communications (19-01-2021)“…The main challenges for programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T cell infiltration, tumor…”
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4
GSH‐Depleted PtCu3 Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy
Published in Advanced functional materials (01-01-2020)“…The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)‐based therapy, improving the outcome of chemodynamic…”
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Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors
Published in Theranostics (2021)“…Development of efficient therapeutic strategy to incorporate ultrasound (US)-triggered sonodynamic therapy (SDT) and ferroptosis is highly promising in cancer…”
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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
Published in Nature communications (23-08-2019)“…Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a…”
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Nanonization strategies for poorly water-soluble drugs
Published in Drug discovery today (01-04-2011)“…Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to…”
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Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy
Published in Nature communications (25-10-2019)“…One of the main challenges for immune checkpoint blockade antibodies lies in malignancies with limited T-cell responses or immunologically “cold” tumors…”
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9
Size-Dependent Ag2S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy
Published in ACS nano (28-02-2017)“…Ag2S nanoparticles are increasingly important in biomedicine, such as in cancer imaging. However, there has been only limited success in the exploration of…”
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10
Nanocomposite-Based Photodynamic Therapy Strategies for Deep Tumor Treatment
Published in Small (Weinheim an der Bergstrasse, Germany) (25-11-2015)“…Photodynamic therapy (PDT), as an emerging clinically approved modality, has been used for treatment of various cancer diseases. Conventional PDT strategies…”
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11
Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma
Published in Nature communications (11-11-2022)“…Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an…”
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Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles
Published in Cell research (01-06-2016)“…Developing novel approaches to reverse the drug resistance of tumor-repopulating cells (TRCs) or stem cell-like cancer cells is an urgent clinical need to…”
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13
Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment
Published in Nature communications (05-08-2022)“…Combining immune checkpoint blockade (ICB) therapy with photodynamic therapy (PDT) holds great potential in treating immunologically “cold” tumors, but…”
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14
Long-term exposure to titanium dioxide nanoparticles promotes diet-induced obesity through exacerbating intestinal mucus layer damage and microbiota dysbiosis
Published in Nano research (01-05-2021)“…Titanium dioxide nanoparticles (TiO 2 -NPs) are commonly used as food additives, including some high-fat foods that are risk factors for obesity. However,…”
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Highly Efficient FRET System Capable of Deep Photodynamic Therapy Established on X‑ray Excited Mesoporous LaF3:Tb Scintillating Nanoparticles
Published in ACS applied materials & interfaces (10-06-2015)“…Photodynamic therapy (PDT) for deep-seated tumor is largely impeded by the limited penetration depth of excitation light in tissue. X-ray is considered as an…”
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Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy
Published in ACS nano (24-10-2017)“…Elemental tellurium (Te) nanoparticles are increasingly important in a variety of applications such as thermoelectricity, photoconductivity, and…”
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Improved synergistic anticancer action of quercetin and tamoxifen citrate supported by an electrospun complex nanostructure
Published in Materials & design (01-02-2024)“…[Display omitted] •Tri-chamber nanofibers in the form of core–shell microstructure embedded on one side of the Janus main structure were designed.•Hydrophilic…”
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Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging
Published in Nature communications (03-01-2020)“…Live-cell Raman imaging based on bioorthogonal Raman probes with distinct signals in the cellular Raman-silent region (1800–2800 cm −1 ) has attracted great…”
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Protein-Nanoreactor-Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics
Published in Advanced materials (Weinheim) (01-07-2016)“…Transition metal sulfide nanocrystals are developed as a theranostic platform through the protein‐nanoreactor approach with facile functionalization for…”
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Recent advances in exhaled breath sample preparation technologies for drug of abuse detection
Published in TrAC, Trends in analytical chemistry (Regular ed.) (01-12-2022)“…This current review focuses on contributions to exhaled breath (EB) preparation in drug of abuse (DOA) detection. DOA has caused health hazards, accidents,…”
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