Search Results - "Yang, Xianfa"

Gain-of-function mutations in Trim71 linked to congenital hydrocephalus by Chen, Yingying, Yang, Xianfa, Jing, Naihe

“…The genetic basis of congenital hydrocephalus is only partially understood. A new study in PLOS Biology reports a potential gain-of-function pathological…”
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Dual Roles of Histone H3 Lysine 9 Acetylation in Human Embryonic Stem Cell Pluripotency and Neural Differentiation by Qiao, Yunbo, Wang, Ran, Yang, Xianfa, Tang, Ke, Jing, Naihe

“…Early neurodevelopment requires cell fate commitment from pluripotent stem cells to restricted neural lineages, which involves the epigenetic regulation of…”
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Mitochondrial replacement in macaque monkey offspring by first polar body transfer by Wang, Zhanyang, Li, Yuzhuo, Yang, Xianfa, Wang, Yan, Nie, Yanhong, Xu, Yuting, Zhang, Xiaotong, Lu, Yong, Zhang, Tikui, Liu, Qiming, Jing, Naihe, Liu, Zhen, Sun, Qiang

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Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation by Wang, Ran, Yang, Xianfa, Chen, Jiehui, Zhang, Lin, Griffiths, Jonathan A., Cui, Guizhong, Chen, Yingying, Qian, Yun, Peng, Guangdun, Li, Jinsong, Wang, Liantang, Marioni, John C., Tam, Patrick P. L., Jing, Naihe

“…Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of…”
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Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation by Qiao, Yunbo, Wang, Ran, Yang, Xianfa, Tang, Ke, Jing, Naihe

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Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation by Zhang, Ke, Yu, Fang, Zhu, Jian, Han, Sue, Chen, Jiehui, Wu, Xuanyuan, Chen, Yingying, Shen, Tingyu, Liao, Jiaoyang, Guo, Wenke, Yang, Xianfa, Wang, Ran, Qian, Yun, Yang, Jiaxin, Cheng, Leping, Zhao, Yun, Hui, Chi-Chung, Li, Jinsong, Peng, Guangdun, He, Shuijin, Jing, Naihe, Tang, Ke

“…Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism…”
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Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development by Yang, Guang, Zhou, Changyang, Wang, Ran, Huang, Shisheng, Wei, Yu, Yang, Xianfa, Liu, Yajing, Li, Jianan, Lu, Zongyang, Ying, Wenqin, Li, Xiajun, Jing, Naihe, Huang, Xingxu, Yang, Hui, Qiao, Yunbo

“…The coactivator-associated arginine methyltransferase CARM1 catalyzes the methylation of histone H3 arginine 17/26 (H3R17/26me) and non-histone proteins at…”
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The molecular and cellular choreography of early mammalian lung development by Yang, Xianfa, Chen, Yingying, Yang, Yun, Li, Shiting, Mi, Panpan, Jing, Naihe

“…Mammalian lung development starts from a specific cluster of endodermal cells situated within the ventral foregut region. With the orchestrating of delicate…”
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Wholemount in situ Hybridization for Spatial-temporal Visualization of Gene Expression in Early Post-implantation Mouse Embryos by Yang, Xianfa, Chen, Yingying, Song, Lu, Zhang, Ting, Jing, Naihe

“…Regionalized distribution of genes plays crucial roles in the formation of the spatial pattern in tissues and embryos during development. hybridization has…”
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Subtype-specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer’s disease by Tao, Ran, Yue, Chunmei, Guo, Zhijie, Guo, Wenke, Yao, Yao, Yang, Xianfa, Shao, Zhen, Gao, Chao, Ding, Jianqing, Shen, Lu, Chen, Shengdi, Jing, Naihe

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by massive neuronal loss in the brain. Both cortical glutamatergic neurons…”
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Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells by Xu, He Jax, Yao, Yao, Yao, Fenyong, Chen, Jiehui, Li, Meishi, Yang, Xianfa, Li, Sheng, Lu, Fangru, Hu, Ping, He, Shuijin, Peng, Guangdun, Jing, Naihe

“…Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and…”
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Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells by Liu, Chang, Wang, Ran, He, Zhisong, Osteil, Pierre, Wilkie, Emilie, Yang, Xianfa, Chen, Jun, Cui, Guizhong, Guo, Wenke, Chen, Yingying, Peng, Guangdun, Tam, Patrick P.L., Jing, Naihe

“…The molecular mechanism underpinning the specification of the ectoderm, a transient germ-layer tissue, during mouse gastrulation was examined here in a stem…”
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Gain-of-function mutations in Trim71 linked to congenital hydrocephalus by Yingying Chen, Xianfa Yang, Naihe Jing

“…The genetic basis of congenital hydrocephalus is only partially understood. A new study in PLOS Biology reports a potential gain-of-function pathological…”
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Epigenetic regulation of early neural fate commitment by Qiao, Yunbo, Yang, Xianfa, Jing, Naihe

“…Early neural fate commitment is a key process in neural development and establishment of the central nervous system, and this process is tightly controlled by…”
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Predictive ability of novel and traditional anthropometric measurement indices for kidney stone disease: a cross-sectional study by Lv, Guanglin, Li, Xiang, Zhou, Xin, Wang, Yang, Gu, Ye, Yang, Xianfa

“…Background The aim of our research was to examine the association of novel anthropometric indices (a body shape index (ABSI), waist-to-height ratio (WtHR),…”
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Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages by Yang, Xianfa, Hu, Boqiang, Hou, Yu, Qiao, Yunbo, Wang, Ran, Chen, Yingying, Qian, Yun, Feng, Su, Chen, Jun, Liu, Chang, Peng, Guangdun, Tang, Fuchou, Jing, Naihe

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Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development by Yang, Xianfa, Hu, Boqiang, Liao, Jiaoyang, Qiao, Yunbo, Chen, Yingying, Qian, Yun, Feng, Su, Yu, Fang, Dong, Ji, Hou, Yu, Xu, He, Wang, Ran, Peng, Guangdun, Li, Jinsong, Tang, Fuchou, Jing, Naihe

“…Primary germ layers have the potential to form all tissues in the mature organism, and their formation during gastrulation requires precise epigenetic…”
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TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs by Yang, Xianfa, Wang, Ran, Wang, Xiongjun, Cai, Guoqing, Qian, Yun, Feng, Su, Tan, Fangzhi, Chen, Kun, Tang, Ke, Huang, Xingxu, Jing, Naihe, Qiao, Yunbo

“…Abstract Clinical therapies of pluripotent stem cells (PSCs)-based transplantation have been hindered by frequent development of teratomas or tumors in animal…”
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SUN-050 The Evolutionarily Conserved Function of COUP-TF Genes in the Differentiation of Photoreceptor Cells in the Retina by Zhu, Jian, Feng, Su, Yang, Jiaxin, Wang, Ran, Yang, Xianfa, Yu, Fang, Shen, Tingyu, Cui, Guizhong, Qiao, Yunbo, Peng, Guangdun, Jing, Naihe, Tang, Ke

“…Central nervous system including brain and retina is composed of appropriate number and subtypes of neurons derived from neural progenitor cells. However, our…”
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AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation by Qiao, Yunbo, Wang, Xiongjun, Wang, Ran, Li, Yuanyuan, Yu, Fang, Yang, Xianfa, Song, Lu, Xu, Guoliang, Chin, Y Eugene, Jing, Naihe

“…AF9 mutations have been implicated in human neurodevelopmental diseases and murine Af9 mediates histone methylation during cortical neuron generation. However,…”
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