Search Results - "Yang, Vincent"

Krüppel-like factor 4 (KLF4): What we currently know by Ghaleb, Amr M., Yang, Vincent W.

“…Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell…”
Get full text

Mammalian Krüppel-like factors in health and diseases by McConnell, Beth B, Yang, Vincent W

“…The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological processes that include proliferation, differentiation, growth,…”
Get full text

Krüppel-like factors in mammalian stem cells and development by Bialkowska, Agnieszka B, Yang, Vincent W, Mallipattu, Sandeep K

“…Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in many species. Recent studies have shown that KLFs play a…”
Get full text

Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice by He, Ping, Yang, Jong Won, Yang, Vincent W., Bialkowska, Agnieszka B.

“…Activating mutations in KRAS are detected in most pancreatic ductal adenocarcinomas (PDACs). Expression of an activated form of KRAS (KrasG12D) in pancreata of…”
Get full text

SP and KLF Transcription Factors in Digestive Physiology and Diseases by Kim, Chang-Kyung, He, Ping, Bialkowska, Agnieszka B, Yang, Vincent W

“…Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in…”
Get full text

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy by Kyriazis, Ioannis D., Hoffman, Matthew, Gaignebet, Lea, Lucchese, Anna Maria, Markopoulou, Eftychia, Palioura, Dimitra, Wang, Chao, Bannister, Thomas D., Christofidou-Solomidou, Melpo, Oka, Shin-ichi, Sadoshima, Junichi, Koch, Walter J., Goldberg, Ira J., Yang, Vincent W., Bialkowska, Agnieszka B., Kararigas, Georgios, Drosatos, Konstantinos

“…Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes, accompanied by altered cardiac energetics, impaired mitochondrial function, and…”
Get full text

State of machine and deep learning in histopathological applications in digestive diseases by Kobayashi, Soma, Saltz, Joel H, Yang, Vincent W

“…Machine learning (ML)- and deep learning (DL)-based imaging modalities have exhibited the capacity to handle extremely high dimensional data for a number of…”
Get full text

Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol by Chen, Yu-Fan, Tseng, Chien-Yu, Wang, Hsei-Wei, Kuo, Hung-Chih, Yang, Vincent W., Lee, Oscar K.

“…Liver transplantation is the only definitive treatment for end‐stage cirrhosis and fulminant liver failure, but the lack of available donor livers is a major…”
Get full text

Deep learning-based approach to the characterization and quantification of histopathology in mouse models of colitis by Kobayashi, Soma, Shieh, Jason, Ruiz de Sabando, Ainara, Kim, Julie, Liu, Yang, Zee, Sui Y, Prasanna, Prateek, Bialkowska, Agnieszka B, Saltz, Joel H, Yang, Vincent W

“…Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the gastrointestinal tract. While therapies exist, response can be limited within the…”
Get full text

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses by Bialkowska, Agnieszka B, Ghaleb, Amr M, Nandan, Mandayam O, Yang, Vincent W

“…Understanding the role of factors that regulate intestinal epithelial homeostasis and response to injury and regeneration is important. The current literature…”
Get full text

Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering by Jiang, Wei-Cheng, Cheng, Yu-Hao, Yen, Meng-Hua, Chang, Yin, Yang, Vincent W, Lee, Oscar K

“…Abstract Liver transplantation is the ultimate treatment for severe hepatic failure to date. However, the limited supply of donor organs has severely hampered…”
Get full text

Computational immunohistochemical mapping adds immune context to histological phenotypes in mouse models of colitis by Kobayashi, Soma, Sullivan, Christopher, Bialkowska, Agnieszka B., Saltz, Joel H., Yang, Vincent W.

“…Inflammatory bowel disease (IBD) is characterized by chronic, dysregulated inflammation in the gastrointestinal tract. The heterogeneity of IBD is reflected…”
Get full text

Murine Model for Colitis-Associated Cancer of the Colon by Snider, Ashley J, Bialkowska, Agnieszka B, Ghaleb, Amr M, Yang, Vincent W, Obeid, Lina M, Hannun, Yusuf A

“…Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal…”
Get more information

Near IR Heptamethine Cyanine Dye-Mediated Cancer Imaging by XIAOJIAN YANG, CHUNMENG SHI, HENARY, Maged, STREKOWSKI, Lucjan, CHUNK, Leland W. K, RONG TONG, WEIPING QIAN, ZHAU, Haiyen E, RUOXIANG WANG, GUODONG ZHU, JIANJUN CHENG, YANG, Vincent W, TIANMIN CHENG

“…Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two…”
Get full text

Mushtaq A. Khan, DVM, PhD: Unwavering Supporter for Digestive Diseases Research by Yang, Vincent W

Get full text

Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon by Liu, Yang, Chidgey, Martyn, Yang, Vincent W, Bialkowska, Agnieszka B

“…Krüppel-like factor 5 (KLF5) is a member of the zinc finger family of transcription factors that regulates homeostasis of the intestinal epithelium. Previous…”
Get more information

Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet by Luo, Yongde, Yang, Yaying, Liu, Muyun, Wang, Dan, Wang, Feng, Bi, Yawei, Ji, Juntao, Li, Suyun, Liu, Yan, Chen, Rong, Huang, Haojie, Wang, Xiaojie, Swidnicka-Siergiejko, Agnieszka K., Janowitz, Tobias, Beyaz, Semir, Wang, Guoqiang, Xu, Sulan, Bialkowska, Agnieszka B., Luo, Catherine K., Pin, Christoph L., Liang, Guang, Lu, Xiongbin, Wu, Maoxin, Shroyer, Kenneth R., Wolff, Robert A., Plunkett, William, Ji, Baoan, Li, Zhaoshen, Li, Ellen, Li, Xiaokun, Yang, Vincent W., Logsdon, Craig D., Abbruzzese, James L., Lu, Weiqin

“…Obesity is a risk factor for pancreatic cancer. In mice, a high-fat diet (HFD) and expression of oncogenic KRAS lead to development of invasive pancreatic…”
Get full text

Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy by Hoffman, Matthew, Palioura, Dimitra, Kyriazis, Ioannis D., Cimini, Maria, Badolia, Rachit, Rajan, Sudarsan, Gao, Erhe, Nikolaidis, Nikolas, Schulze, P. Christian, Goldberg, Ira J., Kishore, Raj, Yang, Vincent W., Bannister, Thomas D., Bialkowska, Agnieszka B., Selzman, Craig H., Drakos, Stavros G., Drosatos, Konstantinos

“…We previously showed that cardiomyocyte Krϋppel-like factor (KLF) 5 regulates cardiac fatty acid oxidation. As heart failure has been associated with altered…”
Get full text

Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury by Orzechowska, Emilia J., Katano, Takahito, Bialkowska, Agnieszka B., Yang, Vincent W.

“…Gamma radiation is a commonly used adjuvant treatment for abdominally localized cancer. Since its therapeutic potential is limited due to gastrointestinal (GI)…”
Get full text

IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment by Lin, Xun, Gaudino, Stephen J., Jang, Kyung Ku, Bahadur, Tej, Singh, Ankita, Banerjee, Anirban, Beaupre, Michael, Chu, Timothy, Wong, Hoi Tong, Kim, Chang-Kyung, Kempen, Cody, Axelrad, Jordan, Huang, Huakang, Khalid, Saba, Shah, Vyom, Eskiocak, Onur, Parks, Olivia B., Berisha, Artan, McAleer, Jeremy P., Good, Misty, Hoshino, Miko, Blumberg, Richard, Bialkowska, Agnieszka B., Gaffen, Sarah L., Kolls, Jay K., Yang, Vincent W., Beyaz, Semir, Cadwell, Ken, Kumar, Pawan

“…The Th17 cell-lineage-defining cytokine IL-17A contributes to host defense and inflammatory disease by coordinating multicellular immune responses. The IL-17…”
Get full text