Search Results - "Yang, Victor C."

Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy by Lin, Tingting, Zhao, Pengfei, Jiang, Yifan, Tang, Yisi, Jin, Hongyue, Pan, Zhenzhen, He, Huining, Yang, Victor C, Huang, Yongzhuo

“…Nutrient transporters have been explored for biomimetic delivery targeting the brain. The albumin-binding proteins (e.g., SPARC and gp60) are overexpressed in…”
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Cancer theranostics: the rise of targeted magnetic nanoparticles by Cole, Adam J, Yang, Victor C, David, Allan E

“…Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has increased considerably over the past two decades. This excitement has been…”
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Brain tumor targeting of magnetic nanoparticles for potential drug delivery: Effect of administration route and magnetic field topography by Chertok, Beata, David, Allan E., Yang, Victor C.

“…Our previous studies demonstrated feasibility of magnetically-mediated retention of iron oxide nanoparticles in brain tumors after intravascular…”
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Low molecular weight protamine (LMWP): A nontoxic protamine substitute and an effective cell-penetrating peptide by He, Huining, Ye, Junxiao, Liu, Ergang, Liang, Qiuling, Liu, Quan, Yang, Victor C.

“…Low molecular weight protamine (LMWP) is a peptide fragment produced in our laboratory from enzymatic digestion of native protamine. More than 30 papers…”
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The artificial peroxidase activity of magnetic iron oxide nanoparticles and its application to glucose detection by Yu, Faquan, Huang, Yongzhuo, Cole, Adam J, Yang, Victor C

“…Abstract Aside from their superparamagnetic properties exploited in clinical magnetic resonance imaging (MRI), it was recently discovered that magnetic, iron…”
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Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting by Cole, Adam J, David, Allan E, Wang, Jianxin, Galbán, Craig J, Hill, Hannah L, Yang, Victor C

“…Abstract While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of…”
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Magnetic brain tumor targeting and biodistribution of long-circulating PEG-modified, cross-linked starch-coated iron oxide nanoparticles by Cole, Adam J, David, Allan E, Wang, Jianxin, Galbán, Craig J, Yang, Victor C

“…Abstract Magnetic iron oxide nanoparticles (MNPs) have been studied to circumvent the limitations of status-quo brain tumor therapy and can be targeted by…”
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15 years of ATTEMPTS: A macromolecular drug delivery system based on the CPP-mediated intracellular drug delivery and antibody targeting by Ye, Junxiao, Shin, Meong Cheol, Liang, Qiuling, He, Huining, Yang, Victor C.

“…Traditionally, any drug intended for combating the tumor would distribute profoundly to other organs and tissues as lack of targeting specificity, thus…”
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CPP-Assisted Intracellular Drug Delivery, What Is Next? by Ye, Junxiao, Liu, Ergang, Yu, Zhili, Pei, Xing, Chen, Sunhui, Zhang, Pengwei, Shin, Meong-Cheol, Gong, Junbo, He, Huining, Yang, Victor C

“…For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally…”
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Cell-penetrating peptides: Achievements and challenges in application for cancer treatment by Shin, Meong Cheol, Zhang, Jian, Min, Kyoung Ah, Lee, Kyuri, Byun, Youngro, David, Allan E., He, Huining, Yang, Victor C.

“…One of the major hurdles to cure cancer lies in the low potency of currently available drugs, which could eventually be solved by using more potent therapeutic…”
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The use of low molecular weight protamine chemical chimera to enhance monomeric insulin intestinal absorption by He, Huining, Sheng, Jianyong, David, Allan E, Kwon, Young Min, Zhang, Jian, Huang, Yongzhuo, Wang, Jianxin, Yang, Victor C

“…Abstract Although oral delivery of insulin offers a number of unmatched advantages, it nevertheless is beset by the poor permeability of insulin molecules…”
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Physiologically based pharmacokinetic model for T84.66: a monoclonal anti-CEA antibody by Urva, Shweta R, Yang, Victor C, Balthasar, Joseph P

“…Antibodies directed against tumor associated antigens are being increasingly used for detection and treatment of cancers; however, there is an incomplete…”
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Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-Called Theranostic System by He, Huining, David, Allan, Chertok, Beata, Cole, Adam, Lee, Kyuri, Zhang, Jian, Wang, Jianxin, Huang, Yongzhuo, Yang, Victor C.

“…ABSTRACT In this review, we discussed the establishment of a so-called “theranostic” system by instituting the basic principles including the use of: [1]…”
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Preparation and characterization of lysine-immobilized poly(glycidyl methacrylate) nanoparticle-coated capillary for the separation of amino acids by open tubular capillary electrochromatography by Xu, Liang, Cui, Pengfei, Wang, Dongmei, Tang, Cheng, Dong, Linyi, Zhang, Can, Duan, Hongquan, Yang, Victor C.

“…•Chemically immobilization of PGMA nanoparticles onto capillary inner wall.•PGMA nanoparticle-coated capillary functionalized by lysine for OTCEC.•Baseline…”
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Magnetic nanoparticles for MRI of brain tumors by Wang, Jianxin, Huang, Yongzhuo, David, Allan E, Chertok, Beata, Zhang, Lei, Yu, Faquan, Yang, Victor C

“…Despite advances in surgery and drug discovery, brain tumors remain fatal diseases. Early detection and diagnosis of brain tumors is of great importance for…”
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The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine by Choi, Young-Suk, Lee, Jue Yeon, Suh, Jin Sook, Kwon, Young-Min, Lee, Seung-Jin, Chung, Jun-Key, Lee, Dong-Soo, Yang, Victor C, Chung, Chong-Pyoung, Park, Yoon-Jeong

“…Abstract Small interfering RNAs (siRNAs), used for specific down-regulation of targeted genes, have garnered considerable interest as an attractive new class…”
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Tat-functionalized Ag-Fe3O4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery by Liu, Ergang, Zhang, Meng, Cui, Hui, Gong, Junbo, Huang, Yongzhuo, Wang, Jianxin, Cui, Yanna, Dong, Weibing, Sun, Lu, He, Huining, Yang, Victor C.

“…In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and…”
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Protease-Activatable Hybrid Nanoprobe for Tumor Imaging by Wang, Yaping, Jiang, Yifan, Zhang, Meng, Tan, Jiao, Liang, Jianming, Wang, Huixin, Li, Yaping, He, Huining, Yang, Victor C., Huang, Yongzhuo

“…Tumor‐associated proteases (TAPs), such as legumain, are actively involved in cancer progression; they have been used as biomarkers for diagnosis, prognosis,…”
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Synthetic Skin-Permeable Proteins Enabling Needleless Immunization by Huang, Yongzhuo, Park, Yoon Shin, Moon, Cheol, David, Allan E, Chung, Hee Sun, Yang, Victor C

“…More than skin‐deep: Synthetic skin‐permeable antigens are constructed by conjugation of the cell‐penetrating low‐molecular‐weight protamine (LMWP) peptide to…”
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ATTEMPTS system: a macromolecular prodrug strategy for cancer drug delivery by Huang, Yongzhuo, Park, Yoon Shin, Wang, Jianxin, Moon, Cheol, Kwon, Young Min, Chung, Hee Sun, Park, Yoon Jeong, Yang, Victor C

“…In order to reduce systemic toxicity and effectively deliver macromolecular drug into tumor cells, a system termed "ATTEMPTS" (antibody targeted, [protamine]…”
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