Search Results - "Yang, Tony T"
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Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone
Published in Scientific reports (14-09-2015)“…The transition zone (TZ) of primary cilia serves as a diffusion barrier to regulate ciliogenesis and receptor localization for key signaling events such as…”
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Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions
Published in Cell reports (Cambridge) (01-11-2013)“…Endoplasmic reticulum (ER)-plasma membrane (PM) junctions are highly conserved subcellular structures. Despite their importance in Ca2+ signaling and lipid…”
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Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components
Published in Nature communications (22-05-2018)“…Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during…”
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Resting-State Functional Connectivity of Subgenual Anterior Cingulate Cortex in Depressed Adolescents
Published in Biological psychiatry (1969) (15-12-2013)“…Background Very few studies have been performed to understand the underlying neural substrates of adolescent major depressive disorder (MDD). Studies in…”
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Single-molecule localization microscopy reveals the ultrastructural constitution of distal appendages in expanded mammalian centrioles
Published in Nature communications (27-03-2023)“…Distal appendages (DAPs) are vital in cilia formation, mediating vesicular and ciliary docking to the plasma membrane during early ciliogenesis. Although…”
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White Matter Correlates of Adolescent Depression: Structural Evidence for Frontolimbic Disconnectivity
Published in Journal of the American Academy of Child and Adolescent Psychiatry (01-08-2014)“…Objective Despite the significant prevalence of adolescent depression, little is known about the neuroanatomical basis of this disorder. Functional…”
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Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression
Published in Journal of affective disorders (01-01-2017)“…Abstract Background The incidence of major depressive disorder (MDD) rises during adolescence, yet the neural mechanisms of MDD during this key developmental…”
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Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages
Published in eLife (03-04-2020)“…Subdistal appendages (sDAPs) are centriolar elements that are observed proximal to the distal appendages (DAPs) in vertebrates. Despite the obvious presence of…”
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Localized Brain Volume and White Matter Integrity Alterations in Adolescent Anorexia Nervosa
Published in Journal of the American Academy of Child and Adolescent Psychiatry (01-10-2013)“…Objective The neurobiological underpinnings of anorexia nervosa (AN) are poorly understood. In this study, we tested whether brain gray matter (GM) and white…”
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Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation
Published in The Journal of cell biology (07-10-2019)“…Primary cilia are microtubule-based organelles that play important roles in development and tissue homeostasis. Tau-tubulin kinase-2 (TTBK2) is genetically…”
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A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma
Published in Frontiers in human neuroscience (06-12-2022)“…Childhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of…”
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SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication
Published in Developmental cell (28-07-2014)“…Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how…”
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Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa
Published in Neuropsychopharmacology (New York, N.Y.) (01-01-2016)“…Anorexia nervosa is a severe psychiatric disorder associated with reduced drive to eat. Altered taste-reward circuit white matter fiber organization in…”
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Single-particle tracking localization microscopy reveals nonaxonemal dynamics of intraflagellar transport proteins at the base of mammalian primary cilia
Published in Molecular biology of the cell (21-03-2019)“…Primary cilia play a vital role in cellular sensing and signaling. An essential component of ciliogenesis is intraflagellar transport (IFT), which is involved…”
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Resting state brain subnetwork relates to prosociality and compassion in adolescents
Published in Frontiers in psychology (20-10-2022)“…Adolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent…”
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An exploratory examination of reappraisal success in depressed adolescents: Preliminary evidence of functional differences in cognitive control brain regions
Published in Journal of affective disorders (01-11-2018)“…•Ineffective emotion regulation is a hallmark of depression.•Cognitive reappraisal of emotion is central to many depression therapies.•Use of cognitive…”
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Sucrose activates human taste pathways differently from artificial sweetener
Published in NeuroImage (Orlando, Fla.) (15-02-2008)“…Animal models suggest that sucrose activates taste afferents differently than non-caloric sweeteners. Little information exists how artificial sweeteners…”
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Female-Specific Intergenerational Transmission Patterns of the Human Corticolimbic Circuitry
Published in The Journal of neuroscience (27-01-2016)“…Parents have large genetic and environmental influences on offspring's cognition, behavior, and brain. These intergenerational effects are observed in mood…”
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Neural Correlates of Smartphone Dependence in Adolescents
Published in Frontiers in human neuroscience (07-10-2020)“…Increases in depressive and suicide-related symptoms among U.S. adolescents have been recently linked to increased use of smartphones. Understanding of the…”
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Examining putamen resting-state connectivity markers of suicide attempt history in depressed adolescents
Published in Frontiers in psychiatry (06-06-2024)“…Suicide is a current leading cause of death in adolescents and young adults. The neurobiological underpinnings of suicide risk in youth, however, remain…”
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