Search Results - "Yang, Tian J"

Dose optimization of TBI-223 for enhanced therapeutic benefit compared to linezolid in antituberculosis regimen by Strydom, Natasha, Ernest, Jacqueline P., Imperial, Marjorie, Solans, Belén P., Wang, Qianwen, Tasneen, Rokeya, Tyagi, Sandeep, Soni, Heena, Garcia, Andrew, Bigelow, Kristina, Gengenbacher, Martin, Zimmerman, Matthew, Xie, Min, Sarathy, Jansy P., Yang, Tian J., Dartois, Véronique, Nuermberger, Eric L., Savic, Radojka M.

“…TBI-223, a novel oxazolidinone for tuberculosis, is designed to provide improved efficacy and safety compared to linezolid in combination with bedaquiline and…”
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The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America by GRIMM, Scott W, EINOLF, Heidi J, TONN, George R, VAN HORN, Robert, WANG, Regina W, WONG, Y. Nancy, YANG, Tian J, OBACH, R. Scott, HALL, Steven D, KAN HE, LIM, Heng-Keang, LING, Kah-Hiing John, CHUANG LU, NOMEIR, Amin A, SEIBERT, Eleanore, SKORDOS, Konstantine W

“…Time-dependent inhibition (TDI) of cytochrome P450 (P450) enzymes caused by new molecular entities (NMEs) is of concern because such compounds can be…”
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Toxicity and toxicokinetic assessment of an anti-tubercular drug pretomanid in cynomolgus monkeys by Bruning-Barry, Rebecca, Ambroso, Jeffrey L., Dillberger, John, Yang, Tian J.

“…Pretomanid is a nitroimidazooxazine antimycobacterial drug that was approved in more than 10 countries as part of a three-drug, all oral regimen, consisting of…”
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Role of Biotransformation Studies in Minimizing Metabolism-Related Liabilities in Drug Discovery by Shu, Yue-Zhong, Johnson, Benjamin M., Yang, Tian J.

“…Metabolism-related liabilities continue to be a major cause of attrition for drug candidates in clinical development. Such problems may arise from the…”
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Single Ascending-Dose Study To Evaluate the Safety, Tolerability, and Pharmacokinetics of Sutezolid in Healthy Adult Subjects by Bruinenberg, Paul, Nedelman, Jerry, Yang, Tian J, Pappas, Fran, Everitt, Dan

“…The primary objective of the study was to evaluate the safety and tolerability of single oral doses of sutezolid tablets administered under fasting conditions…”
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Effective Dosing Regimen of 1-Aminobenzotriazole for Inhibition of Antipyrine Clearance in Rats, Dogs, and Monkeys by BALANI, Suresh K, TONG ZHU, YANG, Tian J, ZHI LIU, BING HE, LEE, Frank W

“…1-Aminobenzotriazole (ABT) has been extensively used as a nonspecific inhibitor of cytochromes P450 (P450s) in animals for mechanistic studies, and antipyrine…”
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Advancing the Therapeutic Potential of Indoleamides for Tuberculosis by Lun, Shichun, Tasneen, Rokeya, Chaira, Tridib, Stec, Jozef, Onajole, Oluseye K, Yang, Tian J, Cooper, Christopher B, Mdluli, Khisi, Converse, Paul J, Nuermberger, Eric L, Raj, V Samuel, Kozikowski, Alan, Bishai, William R

“…Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of In the present study, we characterized…”
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CONCURRENT INDUCTION AND MECHANISM-BASED INACTIVATION OF CYP3A4 BY AN l-VALINAMIDE DERIVATIVE by Luo, Gang, Lin, Jianrong, Fiske, William D, Dai, Renke, Yang, Tian J, Kim, Sean, Sinz, Michael, LeCluyse, Edward, Solon, Eric, Brennan, James M, Benedek, Irma H, Jolley, Summer, Gilbert, Darryl, Wang, Lifei, Lee, Frank W, Gan, Liang-Shang

“…DPC 681 ( N -[(3-fluorophenyl)methyl]glycyl- N -{3-[((3-aminophenyl) sulfonyl)-2-(aminophenyl)amino]-(1 S ,2 S )-2-hydroxy-1-(phenyl-methyl)propyl}-3-methyl- l…”
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Phase 1 Study of the Effects of the Tuberculosis Treatment Pretomanid, Alone and in Combination With Moxifloxacin, on the QTc Interval in Healthy Volunteers by Li, Mengchun, Saviolakis, George A., El‐Amin, Wael, Makhene, Mamodikoe K., Osborn, Blaire, Nedelman, Jerry, Yang, Tian J., Everitt, Daniel

“…Tuberculosis (TB) continues to be a serious threat to public health throughout the world. Newer treatments are needed that could offer simplified regimens with…”
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Monoclonal Antibodies Specific and Inhibitory to Human Cytochromes P450 2C8, 2C9, and 2C19 by KRAUSZ, Kristopher W, GOLDFARB, Inna, BUTERS, Jeroen T. M, YANG, Tian J, GONZALEZ, Frank J, GELBOIN, Harry V

“…Hybridomas were isolated that produce 13 monoclonal antibodies (mAbs) that are specific and highly inhibitory to members of the human P450 2C subfamily, 2C8,…”
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Role of cDNA-Expressed Human Cytochromes P450 in the Metabolism of Diazepam by Yang, Tian J, Shou, Magang, Korzekwa, Kenneth R, Gonzalez, Frank J, Gelboin, Harry V, Yang, Shen K

“…The metabolic conversion of diazepam (DZ) to temazepam (TMZ, a C3-hydroxylation product of DZ) and N-desmethyldiazepam (NDZ, an N1-demethylation product of DZ)…”
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Interaction of Ritonavir on Tissue Distribution of a [14C]L-Valinamide, a Potent Human Immunodeficiency Virus-1 Protease Inhibitor, in Rats Using Quantitative Whole-Body Autoradiography by SOLON, Eric G, BALANI, Suresh K, LEE, Frank W, GANG LUO, YANG, Tian J, HAINES, Paula J, LIFEI WANG, DEMOND, Tonya, DIAMOND, Sharon, CHRIST, David D, GAN, Liang-Shang

“…N -[(3-fluorophenyl)methyl]glycyl- N -{3-[((3-aminophenyl)sulfonyl)- 2-(aminophenyl)amino]-(1 S ,2 S )-2-hydroxy-1-(phenylmethyl)propyl}- 3-methyl- l…”
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Effect of Phenobarbital on Hepatic CYP1A1 and CYP1A2 in the Ahr-Null Mouse by Zaher, Hani, Yang, Tian J, Gelboin, Harry V, Fernandez-Salguero, Pedro, Gonzalez, Frank J

“…Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily by both transcriptional and post-transcriptional mechanisms. Using the…”
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Further characterization of the expression in liver and catalytic activity of CYP2B6 by Ekins, S, Vandenbranden, M, Ring, B J, Gillespie, J S, Yang, T J, Gelboin, H V, Wrighton, S A

“…Previous studies in this laboratory have determined the lack of specificity of several antibody and substrate probes of CYP2B6. The goals of the current study…”
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Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery by Gelboin, Harry V, Krausz, Kristopher W, Gonzalez, Frank J, Yang, Tian J

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Eight Inhibitory Monoclonal Antibodies Define the Role of Individual P-450s in Human Liver Microsomal Diazepam, 7-Ethoxycoumarin, and Imipramine Metabolism by YANG, T. J, KRAUSZ, K. W, YANG SAI, GONZALEZ, F. J, GELBOIN, H. V

“…Eight inhibitory monoclonal antibodies (MAbs) individually specific to human cytochrome P-450 (P-450) 1A1, 1A2, 2A6, 2B6, 2C subfamily (2C8, 2C9, 2C18 and…”
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Inhibitory Monoclonal Antibody to Human Cytochrome P450 2B6 by Yang, Tian J, Krausz, Kristopher W, Shou, Magang, Yang, Shen K, Buters, Jeroen T.M, Gonzalez, Frank J, Gelboin, Harry V

“…The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene. A recombinant…”
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Targeted Disruption of the Microsomal Epoxide Hydrolase Gene by Miyata, Masaaki, Kudo, Gen, Lee, Ying-Hue, Fernandez-Salguero, Pedro, Kimura, Shioko, Gonzalez, Frank J., Yang, Tian J., Gelboin, Harry V.

“…Microsomal epoxide hydrolase (mEH) is a conserved enzyme that is known to hydrolyze many drugs and carcinogens, and a few endogenous steroids and bile acids…”
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Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene by Miyata, M, Kudo, G, Lee, Y H, Yang, T J, Gelboin, H V, Fernandez-Salguero, P, Kimura, S, Gonzalez, F J

“…Microsomal epoxide hydrolase (mEH) is a conserved enzyme that is known to hydrolyze many drugs and carcinogens, and a few endogenous steroids and bile acids…”
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Application of 2D-ultrasonography in prenatal assessment of fetal thymus development by YANG Tian, JI Xiang, NIU Jianmei, KONG Xiaoxiao, LV Mingli

“…Objective: To investigate the value of prenatal ultrasound measurement of thymus size and to determine whether maternal administration of euthyrox affects…”
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