Search Results - "Yang, Sung Don"

A High-Resolution (20 m) Simulation of Nighttime Low Temperature Inducing Agricultural Crop Damage with the WRF–LES Modeling System by Noh, Ilseok, Lee, Seung-Jae, Lee, Seoyeon, Kim, Sun-Jae, Yang, Sung-Don

“…In Korea, sudden cold weather in spring occurs repeatedly every year and causes severe damage to field crops and fruit trees. Detailed forecasting of the daily…”
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Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents by Ahn, Jin Hee, Kim, Hye-Min, Jung, Sun Ho, Kang, Seung Kyu, Kim, Kwang Rok, Rhee, Sang Dal, Yang, Sung-Don, Cheon, Hyae Gyeong, Kim, Sung Soo

“…A new series of cyano-pyrazoline derivatives with a secondary amine at P-2 site was synthesized through achiral and chiral synthetic methods and evaluated for…”
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Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein by Lee, Kang-Woo, Lee, Si Hyoung, Kim, Hyuck, Song, Jin-Sook, Yang, Sung-Don, Paik, Sang Gi, Han, Pyung-Lim

“…Numerous transgenic mouse models for Alzheimer's disease (AD) have been generated to recapitulate the histological pathogenesis and behavioral phenotypes of AD…”
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Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein by Lee, Kang-Woo, Im, Joo-Young, Song, Jin-Sook, Lee, Si Hyoung, Lee, Ho-Jeong, Ha, Hye-Yeong, Koh, Jae-Young, Gwag, Byoung Joo, Yang, Sung-Don, Paik, Sang-Gi, Han, Pyung-Lim

“…The β-secretase cleaved Aβ-bearing carboxy-terminal fragments (βCTFs) of amyloid precursor protein (APP) in neural cells have been suggested to be cytotoxic…”
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Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent by Cheon, Hyae Gyeong, Kim, Sun-Mee, Yang, Sung-Don, Ha, Jae Du, Choi, Joong-Kwon

“…Protein tyrosine phosphatase-1B (PTP-1B), a negative regulator of insulin signaling, may be an attractive therapeutic target for type 2 diabetes mellitus. High…”
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Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents by Ahn, Jin Hee, Cho, Sung Yun, Ha, Jae Du, Chu, So Young, Jung, Sun Ho, Jung, Yoon Sung, Baek, Ji Yoen, Choi, In Kyung, Shin, Eun Young, Kang, Seung Kyu, Kim, Sung Soo, Cheon, Hyae Gyeong, Yang, Sung-Don, Choi, Joong-Kwon

“…A new series of 1,2-naphthoquinone derivatives was synthesized by various synthetic methods and evaluated for their ability to inhibit protein tyrosine…”
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Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors by Ahn, Jin Hee, Kim, Jin Ah, Kim, Hye-Min, Kwon, Hyuk-Man, Huh, Sun-Chul, Rhee, Sang Dal, Kim, Kwang Rok, Yang, Sung-Don, Park, Sung-Dae, Lee, Jae Mok, Kim, Sung Soo, Cheon, Hyae Gyeong

“…[Display omitted] A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound…”
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KR‐31378 ameliorates atherosclerosis by blocking monocyte recruitment in hypercholestrolemic mice by Kim, Jiyun, Nam, Ki‐Hoan, Kim, Sun‐Ok, Choi, Jae‐Hoon, Kim, Hyoung‐Chin, Yang, Sung‐Don, Kang, Joo‐Hyoung, Ryu, Young‐Han, Taeg Oh, Goo, Yoo, Sung‐Eun

“…The recruitment of monocytes into the artery wall is a crucial early step in atherogenesis. A novel compound, KR‐31378, has been shown to be a neuroprotective…”
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Repression of phospho-JNK and infarct volume in ischemic brain of JIP1-deficient mice by Im, Joo-Young, Lee, Ko-Woon, Kim, Man Ho, Lee, Si Hyoung, Ha, Hye-Yeong, Cho, Ik-Hyeun, Kim, Doyeun, Yu, Myung Sik, Kim, Jung-Bin, Lee, Ja-Kyeong, Kim, Young Joo, Youn, Byung-Woo, Yang, Sung-Don, Shin, Hee-Sup, Han, Pyung-Lim

“…Mice lacking JIP1, a scaffold protein that organizes JNK pathway components, were constructed independently by two groups. The proposed in vivo function,…”
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Indenone Derivatives:  A Novel Template for Peroxisome Proliferator-Activated Receptor γ (PPARγ) Agonists by Ahn, Jin Hee, Shin, Mi Sik, Jung, Sun Ho, Kang, Seung Kyu, Kim, Kwang Rok, Rhee, Sang Dal, Jung, Won Hoon, Yang, Sung Don, Kim, Seung Jun, Woo, Joo Rang, Lee, Jeong Hyung, Cheon, Hyae Gyeong, Kim, Sung Soo

“…Agonists of peroxisome proliferator-activated receptor γ (PPAR γ) are of interest as a treatment for diabetes, which prompted the identification of a new class…”
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KR-62980: A novel peroxisome proliferator-activated receptor γ agonist with weak adipogenic effects by Kim, Kwang Rok, Lee, Jeong Hyung, Kim, Seung Jun, Rhee, Sang Dal, Jung, Won Hoon, Yang, Sung-Don, Kim, Sung Soo, Ahn, Jin Hee, Cheon, Hyae Gyeong

“…The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the target for the anti-diabetic drugs including thiazolidinediones. We report…”
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Impaired D2 Dopamine Receptor Function in Mice Lacking Type 5 Adenylyl Cyclase by Lee, Ko-Woon, Hong, Jang-Hee, Choi, In Young, Che, Yongzhe, Lee, Ja-Kyeong, Yang, Sung-Don, Song, Chang-Woo, Kang, Ho Sung, Lee, Jae-Heun, Noh, Jai Sung, Shin, Hee-Sup, Han, Pyung-Lim

“…Dopamine receptor subtypes D1 and D2, and many other seven-transmembrane receptors including adenosine receptor A2A, are colocalized in striatum of brain…”
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Fine Localization of Nefl and Nef3 and its Exclusion as Candidate Gene for Lens Rupture 2(lr2) by RHEE, Sang Dal, KIM, Eunmin, YOON, Sungjoo Kim, YANG, Sung-Don, OKUMOTO, Masaaki, HAN, Sang-Seop, SONG, Chang-Woo

“…Cataract causing lr2 gene is found in the CXSD mouse, which is a recombinant inbred strain of BALB/c and STS mice. For the process of positional cloning of…”
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The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1 by Ha, Hye-Yeong, Cho, Ik-Hyun, Lee, Kang-Woo, Lee, Ko-Woon, Song, Ji-Young, Kim, Kyoung-Shim, Yu, Young-Mi, Lee, Ja-Kyeong, Song, Jin-Sook, Yang, Sung-Don, Shin, Hee-Sup, Han, Pyung-Lim

“…The JNK interacting protein, JSAP1, has been identified as a scaffold protein for mitogen-activated protein kinase (MAPK) signaling pathways and as a linker…”
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Glucose intolerance in young TallyHo mice is induced by leptin-mediated inhibition of insulin secretion by Sung, Yoon-Young, Lee, Young-Sil, Jung, Won Hoon, Kim, Hee-Youn, Cheon, Hyae Gyeong, Yang, Sung-Don, Rhee, Sang Dal

“…The pathophysiology of TallyHo mouse, a recently established animal model for type 2 diabetes mellitus, was analyzed at prediabetic state to examine the…”
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Protective effects of pyrrolidine dithiocarbamate against airway inflammation in the ovalbumin-induced mouse model by Kwak, Hyun Jeong, Song, Jin Sook, Heo, Jun Yeong, Yang, Sung Don, Nam, Ji Yeon, Cho, Young Sik, Cheon, Hyae Gyeong

“…Pyrrolidine dithiocarbamate (PDTC) is known to exert anti-tumor and anti-inflammatory effects. However, the effects of PDTC against airway inflammation and its…”
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KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity by Kim, Kwang-Rok, Rhee, Sang-Dal, Hee Youn Kim, Won Hoon Jung, Yang, Sung-Don, Sung Soo Kim, Jin Hee Ahn, Hyae Gyeong Cheon

“…Dipeptidyl peptidase-IV (DPP-IV) is involved in the inactivation of glucagon-like peptide-1 (GLP-1), a potent insulinotropic peptide. Thus, DPP-IV inhibition…”
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PTP-1B inhibitors: Cyclopenta[ d][1,2]-oxazine derivatives by Cho, Sung Yun, Baek, Ji Yoen, Han, Sang Sub, Kang, Seung Kyu, Ha, Jae Du, Ahn, Jin Hee, Lee, Jae Don, Kim, Kwang Rok, Cheon, Hyae Gyeong, Rhee, Sang Dal, Yang, Sung Don, Yon, Gyu Hwan, Pak, Chwang Siek, Choi, Joong-Kwon

“…A series of novel cyclopenta[ d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B…”
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Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold by Cheon, Hyae Gyeong, Kim, Sung-Soo, Kim, Kwang-Rok, Rhee, Sang-Dal, Yang, Sung-Don, Ahn, Jin Hee, Park, Sung-Dae, Lee, Jae Mok, Jung, Won Hoon, Lee, Hye Sook, Kim, Hee Youn

“…Inhibition of dipeptidyl peptidase IV (DPP-IV) activity has been reported to improve nutrient-stimulated insulin secretion through the stabilization of…”
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Lead treatment in vitro at early developmental stage of bone marrow-derived macrophages enhances NO production through IL-1β and IL-6 but not TNF-α by Song, Jin-Sook, Sim, Su-Yeon, Hong, Doo-Pyo, Dal Rhee, Sang, Song, Chang-Woo, Han, Sang-Seop, Yang, Sung-Don

“…Lead (Pb 2+) is known to decrease or block nitric oxide (NO) production by mature macrophages (mφ). Bone marrow cells were treated with various doses of lead…”
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