Search Results - "Yang, Run‐Ze"
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Involvement of oxidative stress‐induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis
Published in Journal of cellular physiology (01-04-2021)“…Ferroptosis is a necrotic form of regulated cell death that was associated with lipid peroxidation and free iron‐mediated Fenton reactions. It has been…”
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Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction
Published in Journal of the American Chemical Society (24-10-2018)“…Enantioselective intramolecular dearomative Heck reactions have been developed by Pd-catalyzed cross-coupling of aryl halides or aryl triflates with the…”
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Exosomes derived from vascular endothelial cells antagonize glucocorticoid‐induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts
Published in Journal of cellular physiology (01-09-2021)“…High dose and long‐term steroid treatment can alter antioxidative ability and decrease the viability and function of osteoblasts, leading to osteoporosis and…”
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Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy
Published in Experimental & molecular medicine (18-11-2019)“…The main pathological mechanism of intervertebral disc degeneration (IVDD) is the programmed apoptosis of nucleus pulposus (NP) cells. Oxidative stress is a…”
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Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination
Published in Cell death & disease (15-05-2021)“…Bone health requires adequate bone mass, which is maintained by a critical balance between bone resorption and formation. In our study, we identified beraprost…”
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Identification and Management of Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury
Published in Frontiers in neurology (25-02-2020)“…Paroxysmal sympathetic hyperactivity (PSH) has predominantly been described after traumatic brain injury (TBI), which is associated with hyperthermia,…”
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HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway
Published in Frontiers in endocrinology (Lausanne) (28-01-2020)“…Long-term and high dose glucocorticoid treatment can cause decreased viability and function of osteoblasts, which leads to osteoporosis and osteonecrosis. In…”
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NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production
Published in Frontiers in cell and developmental biology (20-11-2020)“…Osteosarcoma (OS) accounts for a large proportion of the types of bone tumors that are newly diagnosed, and is a relatively common bone tumor. However, there…”
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PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy
Published in International journal of biological macromolecules (01-09-2019)“…Apoptosis of annulus fibrosus (AF) is observed widely in intervertebral disc degeneration (IVDD) which causes weaken of tension in the annulus of…”
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Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis
Published in Aging (Albany, NY.) (15-02-2021)“…Exosomes are major mediators of cell-to-cell communication, and are involved in many physiological and pathological processes. Recently, the roles of exosomes…”
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Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration
Published in International journal of biological sciences (2023)“…Mitochondrial unfold protein response (UPR ) can induce mitophagy to protect cell from unfold protein. However, how UPR induces mitophagy to protect cell is…”
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The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy
Published in Cell biology and toxicology (13-03-2024)“…Intervertebral disc degeneration (IVDD) is an aging disease that results in a low quality of life and heavy socioeconomic burden. The mitochondrial unfolded…”
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Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma
Published in Aging (Albany, NY.) (20-09-2020)“…Many studies have revealed the function of long noncoding RNA (LncRNA) in regulating tumorigenesis of osteosarcoma (OS). As a subgroup of LncRNA, small…”
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脐静脉内皮细胞外泌体对炎症因子刺激下前软骨细胞凋亡的影响
Published in 上海交通大学学报(医学版) (28-02-2021)“…R684.3; 目的·探讨脐静脉内皮细胞外泌体对炎症刺激下小鼠前软骨细胞ATDC5凋亡的影响.方法·采用试剂盒分离人脐静脉内皮细胞(human umbilical vein endothelial cell,HUVEC)外泌体,采用Western blotting检测外泌体标志蛋白肿瘤易感基因101(tumor…”
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京郊强降雨条件下不同水土保持治理措施配置模式效益评价
Published in 水土保持学报 (2022)“…S157.2; 以石匣小流域水土保持科技示范园10个不同水土保持措施配置模式的径流小区为研究对象,分析当地2004-2019年降雨格局变化,并以发生在2010-2018年的19次代表性强降雨作为样本降雨事件,探究不同配置模式对土壤侵蚀与面源污染特征的影响.结果…”
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