Search Results - "Yang, RSH"

Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment by Raymond S. H. Yang, Chang, Louis W., Jui-Pin Wu, Ming-Hsien Tsai, Hsiu-Jen Wang, Yu-Chun Kuo, Teng-Kuang Yeh, Chung Shi Yang, Pinpin Lin

“…Background: Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about…”
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Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data by Lyons, Michael A., Yang, Raymond S. H., Mayeno, Arthur N., Reisfeld, Brad

“…Background: One problem of interpreting population-based biomonitoring data is the reconstruction of corresponding external exposure in cases where no such…”
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Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk by Lehmann, Geniece M., Verner, Marc-André, Luukinen, Bryan, Henning, Cara, Assimon, Sue Anne, LaKind, Judy S., McLanahan, Eva D., Phillips, Linda J., Davis, Matthew H., Powers, Christina M., Hines, Erin P., Haddad, Sami, Longnecker, Matthew P., Poulsen, Michael T., Farrer, David G., Marchitti, Satori A., Tan, Yu-Mei, Swartout, Jeffrey C., Sagiv, Sharon K., Welsh, Clement, Campbell, Jerry L., Foster, Warren G., Yang, Raymond S. H., Fenton, Suzanne E., Tornero-Velez, Rogelio, Francis, Bettina M., Barnett, John B., El-Masri, Hisham A., Simmons, Jane Ellen

“…Abstract Lipophilic persistent environmental chemicals (LPECs) have the potential to accumulate within a woman's body lipids over the course of many years…”
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Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results by Redding, Laurel E., Sohn, Michael D., McKone, Thomas E., Chen, Jein-Wen, Wang, Shu-Li, Hsieh, Dennis P. H., Yang, Raymond S. H.

“…Background: One of the most serious human health concerns related to environmental contamination with polychlorinated biphenyls (PCBs) is the presence of these…”
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Commentary: some critical issues and concerns related to research advances on the toxicology of chemical mixtures

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Chemical Mixtures Research: Significance and Future Perspectives by Suk, William A., Olden, Kenneth, Raymond S. H. Yang

“…The study of chemical mixtures is an important area of research because of its potential impact on how risk is assessed in populations exposed to multiple…”
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Initial analyses of the relationship between “Thresholds” of toxicity for individual chemicals and “Interaction Thresholds” for chemical mixtures by Yang, Raymond S.H., Dennison, James E.

“…The inter-relationship of “Thresholds” between chemical mixtures and their respective component single chemicals was studied using three sets of data and two…”
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Biochemical Reaction Network Modeling:  Predicting Metabolism of Organic Chemical Mixtures by Mayeno, Arthur N, Yang, Raymond S. H, Reisfeld, Brad

“…All organisms are exposed to multiple xenobiotics, through food, environmental contamination, and drugs. These xenobiotics often undergo biotransformation, a…”
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Toxicological Interactions among Arsenic, Cadmium, Chromium, and Lead in Human Keratinocytes by Bae, Dong-Soon, Gennings, Chris, Carter, Walter H., Yang, Raymond S. H., Campain, Julie A.

“…To evaluate health effects of chemical mixtures, such as multiple heavy metals in drinking water, we have been developing efficient and accurate hazard…”
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Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling by Belfiore, Carol J, Yang, Raymond S.H, Chubb, Laura S, Lohitnavy, Manupat, Lohitnavy, Ornrat S, Andersen, Melvin E

“…Abstract Chlordecone (CD) and mirex (M) differ by a single carbonyl group in CD in place of two chlorines in M. Although both compounds are lipophilic, their…”
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In Silico Toxicology: Simulating Interaction Thresholds for Human Exposure to Mixtures of Trichloroethylene, Tetrachloroethylene, and 1,1,1-Trichloroethane by Dobrev, Ivan D., Andersen, Melvin E., Raymond S. H. Yang

“…In this study, we integrated our understanding of biochemistry, physiology, and metabolism of three commonly used organic solvents with computer simulation to…”
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Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane by Lu, Yasong, Rieth, Susan, Lohitnavy, Manupat, Dennison, James, El-Masri, Hisham, Barton, Hugh A., Bruckner, James, Yang, Raymond S.H.

“…PBPK modeling has been increasingly applied in chemical risk assessment for dose, route, and species extrapolation. The use of PBPK modeling was explored in…”
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Characterization of the Pharmacokinetics of Gasoline Using PBPK Modeling with a Complex Mixtures Chemical Lumping Approach by Dennison, James E., Andersen, Melvin E., Yang, Raymond S. H.

“…Gasoline consists of a few toxicologically significant components and a large number of other hydrocarbons in a complex mixture. By using an integrated,…”
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Characterization of Gene Expression Changes Associated with MNNG, Arsenic, or Metal Mixture Treatment in Human Keratinocytes: Application of cDNA Microarray Technology by Bae, Dong-Soon, Hanneman, William H., Raymond S. H. Yang, Campain, Julie A.

“…The identification of molecular markers related to critical biological processes during carcinogenesis may aid in the evaluation of carcinogenic potentials of…”
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Development of a Physiologically Based Pharmacokinetic Model for Volatile Fractions of Gasoline Using Chemical Lumping Analysis by Dennison, James E, Andersen, Melvin E, Clewell, Harvey J, Yang, Raymond S. H

“…Physiologically based pharmacokinetic (PBPK) models have often been used to describe the absorption, distribution, metabolism, and excretion of chemicals in…”
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An Updated Physiologically Based Pharmacokinetic Model for Hexachlorobenzene: Incorporation of Pathophysiological States following Partial Hepatectomy and Hexachlorobenzene Treatment by Lu, Yasong, Lohitnavy, Manupat, Reddy, Micaela B., Lohitnavy, Ornrat, Ashley, Amanda, Yang, Raymond S. H.

“…Physiologically based pharmacokinetic (PBPK) modeling is generally used for describing xenobiotic disposition in animals and humans with normal physiological…”
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Effect of PCBs on the lactational transfer of methyl mercury in mice: PBPK modeling by Lee, Sun Ku, Hamer, Dwayne, Bedwell, Cathy L, Lohitnavy, Manupat, Yang, Raymond S.H

“…Abstract MeHg and PCB exposure to lactating mice were analyzed and a physiologically based pharmacokinetic (PBPK) model was developed to describe the…”
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Pharmacokinetics, metabolism, and carcinogenicity of arsenic by Pott, W A, Benjamin, S A, Yang, R S

“…The carcinogenicity of arsenic in humans has been unambiguously demonstrated in a variety of epidemiological studies encompassing geographically diverse study…”
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A reaction network model for CYP2E1-mediated metabolism of toxicant mixtures by Reisfeld, Brad, Yang, Raymond S.H.

“…In this paper, we describe a modeling approach to predict the interlinked pathways and kinetics resulting from CYP2E1-mediated metabolism of both pure species…”
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Some critical issues and concerns related to research advances on toxicology of chemical mixtures by Yang, R S

“…This paper addresses some of the issues and concerns on research advances on the toxicology of chemical mixtures. Emphases will be selectively given to the…”
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