Search Results - "Yang, Qiuhua"
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PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension
Published in Proceedings of the National Academy of Sciences - PNAS (02-07-2019)“…Increased glycolysis in the lung vasculature has been connected to the development of pulmonary hypertension (PH). We therefore investigated whether glycolytic…”
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Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia
Published in Pharmacological research (01-08-2019)“…[Display omitted] Acute lung injury (ALI) is one of the leading causes of death in sepsis. Endothelial inflammation and dysfunction play a prominent role in…”
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PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
Published in Nature communications (07-11-2018)“…Increased aerobic glycolysis in endothelial cells of atheroprone areas of blood vessels has been hypothesized to drive increased inflammation and lesion burden…”
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Quantum dot-based immunochromatography test strip for rapid, quantitative and sensitive detection of alpha fetoprotein
Published in Biosensors & bioelectronics (15-12-2011)“…Rapid, quantitative detection of tumor markers with high sensitivity and specificity is critical to clinical diagnosis and treatment of cancer. We describe…”
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Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity
Published in Hepatology (Baltimore, Md.) (01-07-2018)“…Adenosine 2A receptor (A2AR) exerts protective roles in endotoxin‐ and/or ischemia‐induced tissue damage. However, the role for A2AR in nonalcoholic fatty…”
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Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
Published in Nature communications (16-10-2017)“…The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial…”
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Comprehensive Similarity Algorithm and Molecular Dynamics Simulation-Assisted Terahertz Spectroscopy for Intelligent Matching Identification of Quorum Signal Molecules (N-Acyl-Homoserine Lactones)
Published in International journal of molecular sciences (01-02-2024)“…To investigate the mechanism of aquatic pathogens in quorum sensing (QS) and decode the signal transmission of aquatic Gram-negative pathogens, this paper…”
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Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis
Published in Nature communications (19-09-2017)“…Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including ischemic retinopathies. Here, we…”
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Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Published in Frontiers in immunology (16-11-2023)“…Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the…”
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Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia‐induced brain injury
Published in British journal of pharmacology (01-07-2019)“…Background and Purpose Inactivation of the gene for adenosine A2A receptors (ADORA2A for humans and Adora2a for rodents) protects against brain injury in…”
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Lactic acid bacteria, Enterococcus faecalis Y17 and Pediococcus pentosaceus G11, improved growth performance, and immunity of mud crab (Scylla paramamosain)
Published in Fish & shellfish immunology (01-10-2019)“…Mud crabs (Scylla paramamosain), a commercially important cultured species in the southeastern region of China, is usually infected by Vibriosis or parasites,…”
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Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition
Published in Pharmacological research (01-05-2024)“…Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and morbidity and mortality rates continue to rise. Atherosclerosis constitutes the…”
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Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis
Published in EMBO molecular medicine (01-09-2017)“…The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function of the adenosine‐metabolizing enzyme…”
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Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic rats
Published in Diabetology and metabolic syndrome (30-10-2023)“…Abstract Background Physical exercise is the first-line intervention for prediabetes, and metformin is the most widely used oral insulin-sensitizing agent…”
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PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis
Published in Cells (Basel, Switzerland) (01-08-2023)“…Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis…”
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UDP-Glucosyltransferases Induced by Nosema bombycis Provide Resistance to Microsporidia in Silkworm (Bombyx mori)
Published in Insects (Basel, Switzerland) (07-09-2021)“…As a silkworm pathogen, the microsporidian N. bombycis can be transovarially transmitted from parent to offspring and seriously impedes sericulture industry…”
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Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy
Published in JCI insight (08-12-2022)“…Pathological angiogenesis is a major cause of irreversible blindness in individuals of all age groups with proliferative retinopathy (PR). Mononuclear…”
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Transcriptome analysis of sea cucumber (Apostichopus japonicus) in southern China under heat stress
Published in Aquaculture reports (01-06-2024)“…Sea cucumber (Apostichopus japonicus) is a significant aquatic economic species globally. However, the advancement of the sea cucumber aquaculture industry is…”
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Transcriptome and Metabolome Analyses of Sea Cucumbers Apostichopus japonicus in Southern China During the Summer Aestivation Period
Published in Journal of Ocean University of China (01-02-2021)“…Aestivation is a common strategy of sea cucumbers ( Apostichopus japonicus ) in response to high-temperature conditions. Previous studies have individually…”
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