Search Results - "Yang, Likui"

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells by Bae, Jong-Sup, Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.

“…Recent studies have indicated that activated protein C (APC) may exert its cytoprotective and anti-inflammatory activities through the endothelial protein C…”
Get full text

Nonlinear vibration of a buckled/damaged BNC nanobeam transversally impacted by a high-speed C60 by Shi, Jiao, Yang, Likui, Shen, Jianhu, Cai, Kun

“…Nanotube can be used as a mass sensor. To design a mass sensor for evaluating a high-speed nanoparticle, in this study, we investigated the impact vibration of…”
Get full text

Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells by Bae, Jong-Sup, Yang, Likui, Rezaie, Alireza R

“…Ever-increasing evidence in the literature suggests that the antiinflammatory and cytoprotective properties of activated protein C (APC) are mediated through…”
Get full text

Engineering a Disulfide Bond to Stabilize the Calcium-binding Loop of Activated Protein C Eliminates Its Anticoagulant but Not Its Protective Signaling Properties by Bae, Jong-Sup, Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.

“…In addition to an anticoagulant activity, activated protein C (APC) also exhibits anti-inflammatory and cytoprotective properties. These properties may…”
Get full text

Residues of the 39-Loop Restrict the Plasma Inhibitor Specificity of Factor IXa by Yang, Likui, Rezaie, Alireza R.

“…The two plasma inhibitors, protein Z-dependent protease inhibitor (ZPI) and tissue factor pathway inhibitor (TFPI), effectively inhibit the activity of…”
Get full text

Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population by Ding, Qiulan, Yang, Likui, Hassanian, Seyed Mahdi, Rezaie, A R

“…Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting…”
Get more information

Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombin by Rana, Soumendra, Yang, Likui, Hassanian, Seyed Mahdi, Rezaie, Alireza R.

“…Factor Xa (FXa) elicits intracellular signaling responses through the activation of protease‐activated receptor 2 (PAR2) and possibly also through PAR1 in…”
Get full text

Engineering D-helix of antithrombin in alpha-1-proteinase inhibitor confers antiinflammatory properties on the chimeric serpin by Yang, L, Dinarvand, P, Qureshi, S H, Rezaie, A R

“…Antithrombin (AT) is a heparin-binding serpin in plasma which regulates the proteolytic activity of procoagulant proteases of the clotting cascade. In addition…”
Get more information

Identification of a Specific Exosite on Activated Protein C for Interaction with Protease-activated Receptor 1 by Yang, Likui, Bae, Jong-Sup, Manithody, Chandrashekhara, Rezaie, Alireza R.

“…Activated protein C (APC) is a vitamin K-dependent plasma serine protease which down-regulates the clotting cascade by inactivating procoagulant factors Va and…”
Get full text

Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase by Qureshi, Shabir H, Yang, Likui, Rezaie, Alireza R

“…Factor IXa (FIXa) is a vitamin K-dependent coagulation serine protease which binds to factor VIIIa (FVIIIa) on negatively charged phospholipid vesicles (PCPS)…”
Get more information

Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z by Qureshi, Shabir H., Lu, Qiuya, Manithody, Chandrashekhara, Yang, Likui, Rezaie, Alireza R.

“…Protein Z (PZ) has been reported to promote the inactivation of factor Xa (FXa) by PZ-dependent protease inhibitor (ZPI) by about three orders of magnitude…”
Get full text

Characterization of the Heparin-Binding Site of the Protein Z‑Dependent Protease Inhibitor by Yang, Likui, Ding, Qiulan, Huang, Xin, Olson, Steven T., Rezaie, Alireza R.

“…High-molecular weight heparins promote the protein Z-dependent protease inhibitor (ZPI) inhibition of factors Xa (FXa) and XIa (FXIa) by a template mechanism…”
Get full text

Characterization of Protein Z‑Dependent Protease Inhibitor/Antithrombin Chimeras Provides Insight into the Serpin Specificity of Coagulation Proteases by Yang, Likui, Rezaie, Alireza R

“…Protein Z (PZ)-dependent protease inhibitor (ZPI) and antithrombin (AT) are two physiological serpin inhibitors involved in the regulation of proteolytic…”
Get full text

Calcium-binding sites of the thrombin-thrombomodulin-protein C complex: possible implications for the effect of platelet factor 4 on the activation of vitamin K-dependent coagulation factors by Yang, Likui, Rezaie, Alireza R

“…The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at…”
Get more information

Protein Z-dependent Protease Inhibitor Binds to the C-terminal Domain of Protein Z by Rezaie, Alireza R., Bae, Jong-Sup, Manithody, Chandrashekhara, Qureshi, Shabir H., Yang, Likui

“…Protein Z (PZ) is a multidomain vitamin K-dependent plasma protein that functions as a cofactor to promote the inactivation of factor Xa (fXa) by PZ-dependent…”
Get full text

Activation of Protein C by the Thrombin-Thrombomodulin Complex: Cooperative Roles of Arg-35 of Thrombin and Arg-67 of Protein C by Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.

“…The binding of Ca²⁺ to the 70-80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is…”
Get full text

Contribution of exosite occupancy by heparin to the regulation of coagulation proteases by antithrombin by Yang, L, Manithody, C, Qureshi, S H, Rezaie, A R

“…Heparin promotes the antithrombin (AT) inactivation of factors IXa (fIXa) and Xa (fXa) through a conformational activation of the serpin and also by a template…”
Get more information

Localization of the Heparin Binding Exosite of Factor IXa by Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.

“…Factor IXa (FIXa) is known to have a binding site for heparin that has not been mapped by a mutagenesis study. By homology modeling based on structural data,…”
Get full text

Thrombomodulin Allosterically Modulates the Activity of the Anticoagulant Thrombin by Rezaie, Alireza R., Yang, Likui

“…Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that…”
Get full text

Piecewise model and experiment of power chuck’s gripping force loss during high speed turning by Zhou, Cheng, Yang, HuaYong, Yang, LiKui, Qing, Rong

“…High speed power chucks are important function units in high speed turning. The gripping force loss is the primary factor limiting the rotational speed of…”
Get full text