Search Results - "Yang, Lei Xiang"

Neurodegenerative Charcot–Marie–Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases by Wei, Na, Zhang, Qian, Yang, Xiang-Lei

“…Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that catalyze the first reaction in protein biosynthesis, namely the charging of transfer RNAs (tRNAs)…”
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Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration by Ishimura, Ryuta, Nagy, Gabor, Dotu, Ivan, Zhou, Huihao, Yang, Xiang-Lei, Schimmel, Paul, Senju, Satoru, Nishimura, Yasuharu, Chuang, Jeffrey H., Ackerman, Susan L.

“…In higher eukaryotes, transfer RNAs (tRNAs) with the same anticodon are encoded by multiple nuclear genes, and little is known about how mutations in these…”
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PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications by Shi, Junchao, Zhang, Yunfang, Tan, Dongmei, Zhang, Xudong, Yan, Menghong, Zhang, Ying, Franklin, Reuben, Shahbazi, Marta, Mackinlay, Kirsty, Liu, Shichao, Kuhle, Bernhard, James, Emma R., Zhang, Liwen, Qu, Yongcun, Zhai, Qiwei, Zhao, Wenxin, Zhao, Linlin, Zhou, Changcheng, Gu, Weifeng, Murn, Jernej, Guo, Jingtao, Carrell, Douglas T., Wang, Yinsheng, Chen, Xuemei, Cairns, Bradley R., Yang, Xiang-lei, Schimmel, Paul, Zernicka-Goetz, Magdalena, Cheloufi, Sihem, Zhang, Ying, Zhou, Tong, Chen, Qi

“…Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA…”
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New functions of aminoacyl-tRNA synthetases beyond translation by Schimmel, Paul, Guo, Min, Yang, Xiang-Lei

“…Aminoacyl tRNA synthetases (aaRSs) have progressively added domains and motifs that have no connection to aminoacylation. These additions equip aaRSs with new…”
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Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis by Shi, Yi, Liu, Ze, Zhang, Qian, Vallee, Ingrid, Mo, Zhongying, Kishi, Shuji, Yang, Xiang-Lei

“…Hypoxia-induced angiogenesis maintains tissue oxygen supply and protects against ischemia but also enhances tumor progression and malignancy. This is mediated…”
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Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy by Mo, Zhongying, Zhao, Xiaobei, Liu, Huaqing, Hu, Qinghua, Chen, Xu-Qiao, Pham, Jessica, Wei, Na, Liu, Ze, Zhou, Jiadong, Burgess, Robert W., Pfaff, Samuel L., Caskey, C. Thomas, Wu, Chengbiao, Bai, Ge, Yang, Xiang-Lei

“…Dominant mutations in glycyl-tRNA synthetase (GlyRS) cause a subtype of Charcot-Marie-Tooth neuropathy (CMT2D). Although previous studies have shown that GlyRS…”
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ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase by Zhou, Huihao, Sun, Litao, Yang, Xiang-Lei, Schimmel, Paul

“…The crystal structure of prolyl tRNA synthetase simultaneously bound to its substrate ATP and its inhibitor halofuginone, a derivative of a compound used to…”
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Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase by Chen, Bingyi, Luo, Siting, Zhang, Songxuan, Ju, Yingchen, Gu, Qiong, Xu, Jun, Yang, Xiang-Lei, Zhou, Huihao

“…The polyketide natural product reveromycin A (RM-A) exhibits antifungal, anticancer, anti-bone metastasis, anti-periodontitis and anti-osteoporosis activities…”
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CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase by He, Weiwei, Bai, Ge, Zhou, Huihao, Wei, Na, White, Nicholas M., Lauer, Janelle, Liu, Huaqing, Shi, Yi, Dumitru, Calin Dan, Lettieri, Karen, Shubayev, Veronica, Jordanova, Albena, Guergueltcheva, Velina, Griffin, Patrick R., Burgess, Robert W., Pfaff, Samuel L., Yang, Xiang-Lei

“…Charcot–Marie–Tooth diseases are hereditary peripheral neuropathies for which there are currently no effective therapies; here the type 2D subtype of these…”
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Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy by Bervoets, Sven, Wei, Na, Erfurth, Maria-Luise, Yusein-Myashkova, Shazie, Ermanoska, Biljana, Mateiu, Ligia, Asselbergh, Bob, Blocquel, David, Kakad, Priyanka, Penserga, Tyrone, Thomas, Florian P, Guergueltcheva, Velina, Tournev, Ivailo, Godenschwege, Tanja, Jordanova, Albena, Yang, Xiang-Lei

“…Charcot-Marie-Tooth disease (CMT) is a length-dependent peripheral neuropathy. The aminoacyl-tRNA synthetases constitute the largest protein family implicated…”
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Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability by Gioelli, Noemi, Neilson, Lisa J., Wei, Na, Villari, Giulia, Chen, Wenqian, Kuhle, Bernhard, Ehling, Manuel, Maione, Federica, Willox, Sander, Brundu, Serena, Avanzato, Daniele, Koulouras, Grigorios, Mazzone, Massimiliano, Giraudo, Enrico, Yang, Xiang-Lei, Valdembri, Donatella, Zanivan, Sara, Serini, Guido

“…The formation of a functional blood vessel network relies on the ability of endothelial cells (ECs) to dynamically rearrange their adhesive contacts in…”
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Functional expansion of human tRNA synthetases achieved by structural inventions by Guo, Min, Schimmel, Paul, Yang, Xiang-Lei

“…Known as an essential component of the translational apparatus, the aminoacyl-tRNA synthetase family catalyzes the first step reaction in protein synthesis,…”
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Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response” by Jones, Julia A., Wei, Na, Cui, Haissi, Shi, Yi, Fu, Guangsen, Rauniyar, Navin, Shapiro, Ryan, Morodomi, Yosuke, Berenst, Nadine, Dumitru, Calin Dan, Kanaji, Sachiko, Yates, John R., Kanaji, Taisuke, Yang, Xiang-Lei

“…Various stress conditions are signaled through phosphorylation of translation initiation factor eukaryotic initiation factor 2α (eIF2α) to inhibit global…”
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Human tRNA synthetase catalytic nulls with diverse functions by Lo, Wing-Sze, Gardiner, Elisabeth, Xu, Zhiwen, Lau, Ching-Fun, Wang, Feng, Zhou, Jie J., Mendlein, John D., Nangle, Leslie A., Chiang, Kyle P., Yang, Xiang-Lei, Au, Kin-Fai, Wong, Wing Hung, Guo, Min, Zhang, Mingjie, Schimmel, Paul

“…Genetic efficiency in higher organisms depends on mechanisms to create multiple functions from single genes. To investigate this question for an enzyme family,…”
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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy by Atkinson, Derek, Nikodinovic Glumac, Jelena, Asselbergh, Bob, Ermanoska, Biljana, Blocquel, David, Steiner, Regula, Estrada-Cuzcano, Alejandro, Peeters, Kristien, Ooms, Tinne, De Vriendt, Els, Yang, Xiang-Lei, Hornemann, Thorsten, Milic Rasic, Vedrana, Jordanova, Albena

“…To identify the unknown genetic cause in a nuclear family with an axonal form of peripheral neuropathy and atypical disease course. Detailed neurologic,…”
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Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy by Rhymes, Elena R., Simkin, Rebecca L., Qu, Ji, Villarroel-Campos, David, Surana, Sunaina, Tong, Yao, Shapiro, Ryan, Burgess, Robert W., Yang, Xiang-Lei, Schiavo, Giampietro, Sleigh, James N.

“…Charcot-Marie-Tooth disease (CMT) is a genetic peripheral neuropathy caused by mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase…”
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Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases by Niehues, Sven, Bussmann, Julia, Steffes, Georg, Erdmann, Ines, Köhrer, Caroline, Sun, Litao, Wagner, Marina, Schäfer, Kerstin, Wang, Guangxia, Koerdt, Sophia N., Stum, Morgane, Jaiswal, Sumit, RajBhandary, Uttam L., Thomas, Ulrich, Aberle, Hermann, Burgess, Robert W., Yang, Xiang-Lei, Dieterich, Daniela, Storkebaum, Erik

“…Dominant mutations in five tRNA synthetases cause Charcot–Marie–Tooth (CMT) neuropathy, suggesting that altered aminoacylation function underlies the disease…”
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Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia by Kanaji, Taisuke, Vo, My-Nuong, Kanaji, Sachiko, Zarpellon, Alessandro, Shapiro, Ryan, Morodomi, Yosuke, Yuzuriha, Akinori, Eto, Koji, Belani, Rajesh, Do, Minh-Ha, Yang, Xiang-Lei, Ruggeri, Zaverio M., Schimmel, Paul

“…New mechanisms behind blood cell formation continue to be uncovered, with therapeutic approaches for hematological diseases being of great interest. Here we…”
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Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis by Park, Min Chul, Kang, Taehee, Jin, Da, Han, Jung Min, Kim, Sang Bum, Park, Yun Jung, Cho, Kiwon, Park, Young Woo, Guo, Min, He, Weiwei, Yang, Xiang-Lei, Schimmel, Paul, Kim, Sunghoon

“…Although adaptive systems of immunity against tumor initiation and destruction are well investigated, less understood is the role, if any, of endogenous…”
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Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect by Nangle, Leslie A, Zhang, Wei, Xie, Wei, Yang, Xiang-Lei, Schimmel, Paul

“…Charcot-Marie-Tooth (CMT) diseases are the most common heritable peripheral neuropathy. At least 10 different mutant alleles of GARS (the gene for glycyl-tRNA…”
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