Search Results - "Yang, Julin"

Validation of visualized transgenic zebrafish as a high throughput model to assay bradycardia related cardio toxicity risk candidates by Wen, Dingsheng, Liu, Aiming, Chen, Feng, Yang, Julin, Dai, Renke

“…ABSTRACT Drug‐induced QT prolongation usually leads to torsade de pointes (TdP), thus for drugs in the early phase of development this risk should be…”
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Induction of P450 3A1/2 and 2C6 by gemfibrozil in Sprague-Dawley rats by Liu, Aiming, Yang, Julin, Zhao, Xin, Jiao, Xiaolan, Zhao, Weihong, Ma, Qing, Tang, Zhiyuan, Dai, Renke

“…Fibrates are a group of peroxisome proliferator-activated receptor α agonists used in the treatment of dyslipidemia; however, they have been reported to cause…”
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PPARα suppresses low-intensity-noise-induced body weight gain in mice: the activated HPA axis plays an critical role by Yan, Zheng, Luo, Jia, Wang, Ying, Yang, Jie, Su, Mingli, Jiang, Lei, Yang, Julin, Dai, Manyun, Liu, Aiming

“…Background As the second most risky environmental pollution, noise imposes threats to human health. Exposure to high-intensity noise causes hearing impairment,…”
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Down-regulation of hepatic CLOCK by PPARα is involved in inhibition of NAFLD by Luo, Jia, Yan, Zheng, Dai, Manyun, Xu, Liping, Zhang, Haoyue, Xi, Yang, Yang, Julin, Liu, Aiming

“…This work aimed to investigate the role of nuclear factor peroxisome proliferator-activated receptor α (PPARα) in modification of circadian clock and their…”
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Exposure to low-intensity noise exacerbates nonalcoholic fatty liver disease by activating hypothalamus pituitary adrenal axis by Luo, Jia, Yan, Zheng, Shen, Yao, Liu, Denong, Su, Mingli, Yang, Jie, Xie, Jiarong, Gao, Hui, Yang, Julin, Liu, Aiming

“…Noise exposure induces metabolic disorders, in a latent, chronic and complex way. However, there is no direct evidence elucidating the relationship between…”
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Hepatocytic AP-1 and STAT3 contribute to chemotaxis in alphanaphthylisothiocyanate-induced cholestatic liver injury by Luo, Yishuang, Kang, Jinyu, Luo, Jia, Yan, Zheng, Li, Shengtao, Lu, Zhuoheng, Song, Yufei, Zhang, Xie, Yang, Julin, Liu, Aiming

“…The development of cholestatic liver injury (CLI) involves inflammation, but the dominant pathway mediating the chemotaxis is not yet established. This work…”
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Inhibition of JNK signalling mediates PPARα‐dependent protection against intrahepatic cholestasis by fenofibrate by Dai, Manyun, Yang, Julin, Xie, Minzhu, Lin, Jiao, Luo, Min, Hua, Huiying, Xu, Gangming, Lin, Hante, Song, Danjun, Cheng, Yuqing, Guo, Bin, Zhao, Jinshun, Gonzalez, Frank J, Liu, Aiming

“…Background and Purpose Fenofibrate, a PPARα agonist, is the most widely prescribed drug for treating hyperlipidaemia. Although fibrate drugs are reported to be…”
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Inhibition of inflammation by SP600125 in cholestatic liver injury is dependent on the administration‑based exposure profile by Zheng, Xiuting, Dai, Manyun, Xu, Gangming, Chang, Liming, Yang, Julin, Liu, Aiming

“…SP600125 is a classic inhibitor of c-Jun-N-terminal kinase (JNK) that is widely used in numerous medicinal studies, but its administration regimen has yet to…”
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Oral administration of nano-titanium dioxide particle disrupts hepatic metabolic functions in a mouse model by Yang, Julin, Luo, Min, Tan, Zhen, Dai, Manyun, Xie, Minzhu, Lin, Jiao, Hua, Huiying, Ma, Qing, Zhao, Jinshun, Liu, Aiming

“…Highlights • Orally administered TiO2 NP deposits in cytoplasm of hepatocytes and disrupts liver metabolism function. • Metabolism assay is a sensitive…”
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Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α‑Naphthylisothiocyanate by Dai, Manyun, Hua, Huiying, Lin, Hante, Xu, Gangming, Hu, Xiaowei, Li, Fei, Gonzalez, Frank J, Liu, Aiming, Yang, Julin

“…α-Naphthylisothiocyanate (ANIT) is an experimental agent used to induce intrahepatic cholestasis. The Ppara-null mouse line is widely employed to explore the…”
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Cholestatic models induced by lithocholic acid and α‑naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling by Xu, Gangming, Dai, Manyun, Zheng, Xiuting, Lin, Hante, Liu, Aiming, Yang, Julin

“…α‑naphthylisothiocyanate (ANIT) is used to induce intrahepatic cholestasis and it is frequently used for investigations into the disease mechanism. The…”
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PPARα mediates night neon light-induced weight gain: role of lipid homeostasis by Luo, Yishuang, Yang, Julin, Kang, Jinyu, Chen, Kuihao, Jin, Xiaofeng, Gonzalez, Frank J, Liu, Aiming

“…Light pollution leads to high risk of obesity but the underlying mechanism is not known except for the influence of altered circadian rhythm. Peroxisome…”
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Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling by Liu, Aiming, Tanaka, Naoki, Sun, Lu, Guo, Bin, Kim, Jung-Hwan, Krausz, Kristopher W., Fang, Zhongze, Jiang, Changtao, Yang, Julin, Gonzalez, Frank J.

“…•Mice treated with saikosaponin d were protected against APAP-induced hepatotoxicity.•Saikosaponin d reversed APAP-induced expression of pro-inflammatory…”
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Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation by Tan, Zhen, Luo, Min, Yang, Julin, Cheng, Yuqing, Huang, Jing, Lu, Caide, Song, Danjun, Ye, Meiling, Dai, Manyun, Gonzalez, Frank J., Liu, Aiming, Guo, Bin

“…Objectives Chlorogenic acid (CGA) is one of the most widely consumed polyphenols in diets and is recognized to be a natural hepatoprotective agent. Here, we…”
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Basal PPARα inhibits bile acid metabolism adaptation in chronic cholestatic model induced by α-naphthylisothiocyanate by Hua, Huiying, Dai, Manyun, Luo, Yishuang, Lin, Hante, Xu, Gangming, Hu, Xiaowei, Xu, Liping, Zhang, Haoyue, Tang, Zhiyuan, Chang, Liming, Liu, Aiming, Yang, Julin

“…•In chronic cholestsis, bile acid metabolism adaptation is inhibited in wild-type mice but not in Ppara-null mice.•FXR pathway is activated in Ppara-null mice,…”
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Cholestatic models induced by lithocholic acid and [alpha]-naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling by Xu, Gangming, Dai, Manyun, Zheng, Xiuting, Lin, Hante, Liu, Aiming, Yang, Julin

“…[alpha]-naphthylisothiocyanate (ANIT) is used to induce intrahepatic cholestasis and it is frequently used for investigations into the disease mechanism. The…”
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Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity by Luo, Min, Tan, Zhen, Dai, Manyun, Song, Danjun, Lin, Jiao, Xie, Minzhu, Yang, Julin, Sun, Lu, Wei, Dengming, Zhao, Jinshun, Gonzalez, Frank J., Liu, Aiming

“…Perfluorodecanoic acid (PFDA) is widely used in production of many daily necessities based on their surface properties and stability. It was assigned as a…”
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In vivo induction of CYP in mice by carbamazepine is independent on PXR by Liu, Aiming, Wang, Chuang, Hehir, Michael, Zhou, Tianbao, Yang, Julin

“…The antiepileptic drug carbamazepine (CBZ) is a typical inducer of cytochrome P450 (CYP) 3A and 2C in the clinic. It is considered a strong constitutive…”
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PPARα‐independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling by Hua, Huiying, Yang, Julin, Lin, Hante, Xi, Yang, Dai, Manyun, Xu, Gangming, Wang, Fuyan, Liu, Lihong, Zhao, Tingqi, Huang, Jing, Gonzalez, Frank J., Liu, Aiming

“…Objectives Metabolic syndrome (MS) is the concurrence of at least three of five medical conditions: obesity, high blood pressure, insulin resistance, high…”
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Schisandrin B and Schisandrol B induce mouse CYP2b10 associated with CAR not PXR by Xie, Minzhu, Lin, Jiao, Kang, Jinyu, Zheng, Xiuting, Fang, Kailu, Luo, Yishuang, Liu, Aiming, Yang, Julin

“…[Display omitted] •Schisandrin B and Schisandrol B strongly induce mouse CYP2B.•The above inductive action is mediated by nuclear receptor CAR.•Reversible and…”
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