Search Results - "Yang, Jianzhang"

Adaptability of AlTiN-based coated tools with green cutting technologies in sustainable machining of 316L stainless steel by Lai, Zhiwei, Wang, Chengyong, Zheng, Lijuan, Huang, Wen, Yang, Jianzhang, Guo, Guangyu, Xiong, Weiqiang

“…This study aimed to explore the adaptability of coated tools with green cutting technologies. The cutting performance of five AlTiN-based coated tools,…”
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Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13 by Yang, Jianzhang, Chang, Yu, Tien, Jean Ching-Yi, Wang, Zhen, Zhou, Yang, Zhang, Pujuan, Huang, Weixue, Vo, Josh, Apel, Ingrid J., Wang, Cynthia, Zeng, Victoria Zhixuan, Cheng, Yunhui, Li, Shuqin, Wang, George Xiaoju, Chinnaiyan, Arul M., Ding, Ke

“…Selective degradation of the cyclin-dependent kinases 12 and 13 (CDK12/13) presents a novel therapeutic opportunity for triple-negative breast cancer (TNBC),…”
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Effect of cryogenic oils-on-water compared with cryogenic minimum quantity lubrication in finishing turning of 17-4PH stainless steel by Lai, Zhiwei, Wang, Chengyong, Zheng, Lijuan, Lin, Haisheng, Yuan, Yaohui, Yang, Jianzhang, Xiong, Weiqiang

“…17-4PH stainless steel is widely used for applications of critical importance owing to its favorable property profile. However, the great mechanical…”
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Targeted inhibition of ZAK ameliorates renal interstitial fibrosis by Shu, Shuangshuang, Liu, Han, Yang, Jianzhang, Tang, Haie, Li, Hao, Liu, Zhuoliang, Zhou, Miaomiao, Zhu, Fengxin, Hu, Zheng, Ding, Ke, Lu, Xiaoyun, Nie, Jing

“…ZAK (sterile alpha motif and leucine zipper-containing kinase) is a newly discovered member of the subfamily of mitogen-activated protein kinase kinase kinases…”
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Design, Synthesis, and Structure–Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile‑α Motif Kinase (ZAK) Inhibitors by Yang, Jianzhang, Shibu, Marthandam Asokan, Kong, Lulu, Luo, Jinfeng, BadrealamKhan, Farheen, Huang, Yanhui, Tu, Zheng-Chao, Yun, Cai-Hong, Huang, Chih-Yang, Ding, Ke, Lu, Xiaoyun

“…ZAK is a new promising target for discovery of drugs with activity against antihypertrophic cardiomyopathy (HCM). A series of 1,2,3-triazole…”
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Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader by Zhou, Licheng, Zhou, Kaijie, Chang, Yu, Yang, Jianzhang, Fan, Bohai, Su, Yuhan, Li, Zilu, Mannan, Rahul, Mahapatra, Somnath, Ding, Ming, Zhou, Fengtao, Huang, Weixue, Ren, Xiaomei, Xu, Jian, Wang, George Xiaoju, Zhang, Jinwei, Wang, Zhen, Chinnaiyan, Arul M., Ding, Ke

“…Selective degradation of cyclin-dependent kinases 12 and 13 (CDK12/13) emerges as a new potential therapeutic approach for triple-negative breast cancer (TNBC)…”
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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition by Chang, Yu, Wang, Xiaoju, Yang, Jianzhang, Tien, Jean Ching-Yi, Mannan, Rahul, Cruz, Gabriel, Zhang, Yuping, Vo, Josh N., Magnuson, Brian, Mahapatra, Somnath, Cho, Hanbyul, Dhanasekaran, Saravana Mohan, Wang, Cynthia, Wang, Zhen, Zhou, Licheng, Zhou, Kaijie, Zhou, Yang, Zhang, Pujuan, Huang, Weixue, Xiao, Lanbo, Liu, Weihuang Raymond, Hamadeh, Rudana, Su, Fengyun, Wang, Rui, Miner, Stephanie J., Cao, Xuhong, Cheng, Yunhui, Mehra, Rohit, Ding, Ke, Chinnaiyan, Arul M.

“…Cyclin-dependent kinases 12/13 play pivotal roles in orchestrating transcription elongation, DNA damage response, and maintenance of genomic stability…”
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Polythienylene–Vinylene Structure–Function Correlations Revealed from Resonance Raman Spectroscopy and Photocurrent Imaging by Gao, Jian, Thomas, Alan K, Yang, Jianzhang, Aldaz, Cody, Yang, Guoshun, Qin, Yang, Grey, John K

“…New structure–function correlations are revealed in poly­(3-alkyl-thienylenevinylene) (P3ATV) derivatives using resonance Raman spectroscopy techniques. P3ATVs…”
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Abstract 3428: Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13 by Chang, Yu, Yang, Jianzhang, Tien, Jean Ching-Yi, Wang, Zhen, Zhou, Yang, Zhang, Pujuan, Huang, Weixue, Vo, Josh, Apel, Ingrid J., Wang, Cynthia, Zeng, Victoria Zhixuan, Cheng, Yunhui, Li, Shuqin, Wang, George Xiaoju, Ding, Ke, Chinnaiyan, Arul M.

“…Abstract Selective degradation of the cyclin-dependent kinases 12 and 13 (CDK12/13) presents a novel therapeutic opportunity for triple-negative breast cancer…”
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Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide by Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Akama, Tsutomu, Zhou, Yasheen, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Cao, Jianxin, Ge, Zhixin, Yang, Jianzhang

“…Novel isoxazoline amide benzoxaboroles were designed and synthesized to optimize the ectoparasiticide activity of this chemistry series against ticks and…”
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CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13 by Tien, Jean Ching-Yi, Luo, Jie, Chang, Yu, Zhang, Yuping, Cheng, Yunhui, Wang, Xiaoju, Yang, Jianzhang, Mannan, Rahul, Mahapatra, Somnath, Shah, Palak, Wang, Xiao-Ming, Todd, Abigail J., Eyunni, Sanjana, Cheng, Caleb, Rebernick, Ryan J., Xiao, Lanbo, Bao, Yi, Neiswender, James, Brough, Rachel, Pettitt, Stephen J., Cao, Xuhong, Miner, Stephanie J., Zhou, Licheng, Wu, Yi-Mi, Labanca, Estefania, Wang, Yuzhuo, Parolia, Abhijit, Cieslik, Marcin, Robinson, Dan R., Wang, Zhen, Feng, Felix Y., Chou, Jonathan, Lord, Christopher J., Ding, Ke, Chinnaiyan, Arul M.

“…Biallelic loss of cyclin-dependent kinase 12 (CDK12) defines a metastatic castration-resistant prostate cancer (mCRPC) subtype. It remains unclear, however,…”
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Design of a Sheet Electron Beam Focusing System for a Sub-terahertz Traveling Wave Tube by Zhang, Lin, Shu, Guoxiang, Yang, Jianzhang, Ouyang, Zhihui, He, Wenlong

“…An offset-pole periodic cusped magnet (PCM) focusing system for an H-band (220-325 GHz) traveling wave tube was designed and optimized using CST-PS. It is…”
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