Search Results - "Yang, Jerry Z."

Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate by Xing, Li, Devadas, Balekudru, Devraj, Rajesh V., Selness, Shaun R., Shieh, Huey, Walker, John K., Mao, Michael, Messing, Dean, Samas, Brian, Yang, Jerry Z., Anderson, Gary D., Webb, Elizabeth G., Monahan, Joseph B.

“…PH‐797804 ((aS)‐3‐{3‐bromo‐4‐[(2,4‐difluorobenzyl)oxy]‐6‐methyl‐2‐oxopyridin‐1(2H)‐yl}‐N,4‐dimethylbenzamde) is a diarylpyridinone inhibitor of p38…”
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Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers by Tang, Fuxing, Ouyang, Hui, Yang, Jerry Z, Borchardt, Ronald T

“…The bidirectional permeation characteristics of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein (P-gp), across…”
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In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs by Yang, Jerry Z, Chen, Weiqing, Borchardt, Ronald T

“…In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs…”
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Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model by Chen, Weiqing, Yang, Jerry Z, Andersen, Rikke, Nielsen, Lisbeth H, Borchardt, Ronald T

“…The permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs [acyloxyalkoxy-based cyclic prodrug of…”
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On the Cauchy–Born approximation at finite temperature by Yang, Jerry Z., Mao, Chao, Li, Xiantao, Liu, Chun

“…•We derive a closed form expression for the first Piola–Kirchhoff stress using asymptotic expansion.•A derivation is presented for systems under periodic…”
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A multiscale coupling method for the modeling of dynamics of solids with application to brittle cracks by Li, Xiantao, Yang, Jerry Z., E, Weinan

“…We present a multiscale model for numerical simulations of dynamics of crystalline solids. The method combines the continuum nonlinear elasto-dynamics model,…”
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Fluticasone and budesonide nanosuspensions for pulmonary delivery: preparation, characterization, and pharmacokinetic studies by Yang, Jerry Z, Young, Anthony L, Chiang, Po-Chang, Thurston, Archie, Pretzer, Denise K

“…This manuscript describes the preparation, characterization, and pharmacokinetic studies for fluticasone and budesonide nanosuspensions in pulmonary delivery…”
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Substituted N-aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors by Devadas, Balekudru, Selness, Shaun R, Xing, Li, Madsen, Heather M, Marrufo, Laura D, Shieh, Huey, Messing, Dean M, Yang, Jerry Z, Morgan, Heidi M, Anderson, Gary D, Webb, Elizabeth G, Zhang, Jian, Devraj, Rajesh V, Monahan, Joseph B

“…A novel series of highly potent and selective p38 MAP kinase inhibitors was developed originating from a substituted N-aryl-6-pyrimidinone scaffold. SAR…”
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Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38α Map Kinase and Map Kinase–Activated Protein Kinase-2 (MK2) Inhibitors in the Dog by Morris, Dale L., O’Neil, Shawn P., Devraj, Rajesh V., Portanova, Joseph P., Gilles, Richard W., Gross, Cindy J., Curtiss, Sandra W., Komocsar, Wendy J., Garner, Debra S., Happa, Fernando A., Kraus, Lori J., Nikula, Kristen J., Monahan, Joseph B., Selness, Shaun R., Galluppi, Gerald R., Shevlin, Kimberly M., Kramer, Jeffrey A., Walker, John K., Messing, Dean M., Anderson, David R., Mourey, Robert J., Whiteley, Laurence O., Daniels, John S., Yang, Jerry Z., Rowlands, Philip C., Alden, Carl L., Davis, John W., Sagartz, John E.

“…Exposure to moderately selective p38α mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild…”
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Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection by Yang, Jerry Z, Bastian, K.Chad, Moore, Randy D, Stobaugh, John F, Borchardt, Ronald T

“…Two analytical methods were developed for quantitative determination of DADLE (H 2N–Tyr– d-Ala–Gly–Phe– d-Leu–COOH) and its two cyclic prodrugs in rat plasma…”
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Uniform accuracy of the quasicontinuum method by E, Weinan, Lu, Jianfeng, Yang, Jerry Z.

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Comparative study of boundary conditions for molecular dynamics simulations of solids at low temperature by Yang, Jerry Z., Li, Xiantao

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Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS) by Carron, Chris P, Trujillo, John I, Olson, Kirk L, Huang, Wei, Hamper, Bruce C, Dice, Tom, Neal, Bradley E, Pelc, Matthew J, Day, Jacqueline E, Rohrer, Douglas C, Kiefer, James R, Moon, Joseph B, Schweitzer, Barbara A, Blake, Tanisha D, Turner, Steve R, Woerndle, Rhonda, Case, Brenda L, Bono, Christine P, Dilworth, Vickie M, Funckes-Shippy, Christie L, Hood, Becky L, Jerome, Gina M, Kornmeier, Christine M, Radabaugh, Melissa R, Williams, Melanie L, Davies, Michael S, Wegner, Craig D, Welsch, Dean J, Abraham, William M, Warren, Chad J, Dowty, Martin E, Hua, Fengmei, Zutshi, Anup, Yang, Jerry Z, Thorarensen, Atli

“…Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a…”
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Generalized Cauchy-Born rules for elastic deformation of sheets, plates, and rods: Derivation of continuum models from atomistic models by Yang, Jerry Z., E, Weinan

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Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38a Map Kinase and Map Kinase-Activated Protein Kinase-2 (MK2) Inhibitors in the Dog by Morris, Dale L, O'Neil, Shawn P, Devraj, Rajesh V, Portanova, Joseph P, Gilles, Richard W, Gross, Cindy J, Curtiss, Sandra W, Komocsar, Wendy J, Garner, Debra S, Happa, Fernando A, Kraus, Lori J, Nikula, Kristen J, Monahan, Joseph B, Selness, Shaun R, Galluppi, Gerald R, Shevlin, Kimberly M, Kramer, Jeffrey A, Walker, John K, Messing, Dean M, Anderson, David R, Mourey, Robert J, Whiteley, Laurence O, Daniels, John S, Yang, Jerry Z, Rowlands, Philip C, Alden, Carl L, Davis, John W, Sagartz, John E

“…Exposure to moderately selective p38a mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild…”
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Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog by Morris, Dale L, O'Neil, Shawn P, Devraj, Rajesh V, Portanova, Joseph P, Gilles, Richard W, Gross, Cindy J, Curtiss, Sandra W, Komocsar, Wendy J, Garner, Debra S, Happa, Fernando A, Kraus, Lori J, Nikula, Kristen J, Monahan, Joseph B, Selness, Shaun R, Galluppi, Gerald R, Shevlin, Kimberly M, Kramer, Jeffrey A, Walker, John K, Messing, Dean M, Anderson, David R, Mourey, Robert J, Whiteley, Laurence O, Daniels, John S, Yang, Jerry Z, Rowlands, Philip C, Alden, Carl L, Davis, 2nd, John W, Sagartz, John E

“…Exposure to moderately selective p38alpha mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild…”
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On the Cauchy-Born Approximation at Finite Temperature by Yang, Jerry Z, Mao, Chao, Li, Xiantao, Liu, Chun

“…We address several issues regarding the derivation and implementation of the Cauchy-Born approximation of the stress at finite temperature. In particular, an…”
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