Tooth loss is associated with brain white matter change and silent infarction among adults without dementia and stroke

Tooth loss is associated with brain white matter change and silent infarction among adults without dementia and stroke

Periodontal disease is a predictor of stroke and cognitive impairment. The association between the number of lost teeth (an indicator of periodontal disease) and silent infarcts and cerebral white matter changes on brain CT was investigated in community-dwelling adults without dementia or stroke. De...

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Bibliographic Details
Published in:Journal of Korean medical science Vol. 28; no. 6; pp. 929 - 933
Main Authors: Minn, Yang-Ki, Suk, Seung-Han, Park, Hyunyoung, Cheong, Jin-Sung, Yang, Hyunduk, Lee, Sungik, Do, Seung-Yeon, Kang, Ji-Sook
Format: Journal Article
Language:English
Published: Korea (South) The Korean Academy of Medical Sciences 01-06-2013
대한의학회
Subjects:
Age Factors
Aged
Alzheimer Disease - diagnosis
Brain - diagnostic imaging
Cross-Sectional Studies
Dementia - pathology
Dementia - prevention & control
Diabetes Complications - diagnosis
Female
Humans
Hyperlipidemias - complications
Hypertension - complications
Interviews as Topic
Male
Middle Aged
Odds Ratio
Original
Periodontal Diseases - complications
Periodontal Diseases - diagnosis
Predictive Value of Tests
Risk Factors
Stroke - pathology
Stroke - prevention & control
Tomography, X-Ray Computed
Tooth Loss
의학일반
Tooth Loss
Health Promotion
Dental Caries
Periodontitis
Risk Factors
Tomography, X-ray Computed
Preventive Health Service
Alzheimer Disease
Leukoencephalopathy
Dementia
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Summary:Periodontal disease is a predictor of stroke and cognitive impairment. The association between the number of lost teeth (an indicator of periodontal disease) and silent infarcts and cerebral white matter changes on brain CT was investigated in community-dwelling adults without dementia or stroke. Dental examination and CT were performed in 438 stroke- and dementia-free subjects older than 50 yr (mean age, 63 ± 7.9 yr), who were recruited for an early health check-up program as part of the Prevention of Stroke and Dementia (PRESENT) project between 2009 and 2010. In unadjusted analyses, the odds ratio (OR) for silent cerebral infarcts and cerebral white matter changes for subjects with 6-10 and > 10 lost teeth was 2.3 (95% CI, 1.38-4.39; P = 0.006) and 4.2 (95% CI, 1.57-5.64; P < 0.001), respectively, as compared to subjects with 0-5 lost teeth. After adjustment for age, education, hypertension, diabetes mellitus, hyperlipidemia, and smoking, the ORs were 1.7 (95% CI, 1.08-3.69; P = 0.12) and 3.9 (95% CI, 1.27-5.02; P < 0.001), respectively. These findings suggest that severe tooth loss may be a predictor of silent cerebral infarcts and cerebral white matter changes in community-dwelling, stroke- and dementia-free adults.
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G704-000345.2013.28.6.029
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2013.28.6.929