Search Results - "Yang, Guo‐Yuan"

The biphasic function of microglia in ischemic stroke by Ma, Yuanyuan, Wang, Jixian, Wang, Yongting, Yang, Guo-Yuan

“…Microglia are brain resident macrophages originated from primitive progenitor cells in the yolk sac. Microglia can be activated within hours and recruited to…”
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Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia by He, Tingting, Li, Wanlu, Song, Yaying, Li, Zongwei, Tang, Yaohui, Zhang, Zhijun, Yang, Guo-Yuan

“…Abstract Background Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia are activated and polarized to either the pro-inflammatory M1…”
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Stroke subtype-dependent synapse elimination by reactive gliosis in mice by Shi, Xiaojing, Luo, Longlong, Wang, Jixian, Shen, Hui, Li, Yongfang, Mamtilahun, Muyassar, Liu, Chang, Shi, Rubing, Lee, Joon-Hyuk, Tian, Hengli, Zhang, Zhijun, Wang, Yongting, Chung, Won-Suk, Tang, Yaohui, Yang, Guo-Yuan

“…The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we…”
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Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion by Zhang, Lin-Yuan, Pan, Jiaji, Mamtilahun, Muyassar, Zhu, Yuan, Wang, Liping, Venkatesh, Ashwin, Shi, Rubing, Tu, Xuanqiang, Jin, Kunlin, Wang, Yongting, Zhang, Zhijun, Yang, Guo-Yuan

“…Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether…”
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Aquaporin-4: A Potential Therapeutic Target for Cerebral Edema by Tang, Guanghui, Yang, Guo-Yuan

“…Aquaporin-4 (AQP4) is a family member of water-channel proteins and is dominantly expressed in the foot process of glial cells surrounding capillaries. The…”
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Crosstalk of Astrocytes and Other Cells during Ischemic Stroke by He, Tingting, Yang, Guo-Yuan, Zhang, Zhijun

“…Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally compose tripartite synapses, blood–brain barrier, and the…”
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Therapeutic application of exosomes in ischaemic stroke by Li, Yongfang, Tang, Yaohui, Yang, Guo-Yuan

“…Ischaemic stroke is a leading cause of long-term disability in the world, with limited effective treatments. Increasing evidence demonstrates that exosomes are…”
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MicroRNA-126-3p/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion by Pan, Jiaji, Qu, Meijie, Li, Yongfang, Wang, Liping, Zhang, Linyuan, Wang, Yongting, Tang, Yaohui, Tian, Heng-Li, Zhang, Zhijun, Yang, Guo-Yuan

“…Background and Purpose- Blood-brain barrier (BBB) disruption is a critical pathological feature after stroke. MicroRNA-126 (miR-126) maintains BBB integrity by…”
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Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post‐ischaemic neuroregeneration and recovery of neurological functions in rats by Zhang, Gaoxiao, Zhang, Tao, Li, Ning, Wu, Liangmiao, Gu, Jianbo, Li, Cuimei, Zhao, Chen, Liu, Wei, Shan, Luchen, Yu, Pei, Yang, Xifei, Tang, Yaohui, Yang, Guo‐Yuan, Wang, Yuqiang, Sun, Yewei, Zhang, Zaijun

“…Background and Purpose Neuronal regeneration from endogenous precursors is an attractive strategy for the treatment of ischaemic stroke. However, most…”
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Brain Microenvironment Responsive and Pro‐Angiogenic Extracellular Vesicle‐Hydrogel for Promoting Neurobehavioral Recovery in Type 2 Diabetic Mice After Stroke by Jiang, Yixu, Wang, Ruiqi, Wang, Cheng, Guo, Yiyan, Xu, Tongtong, Zhang, Zhijun, Yang, Guo‐Yuan, Xu, He, Tang, Yaohui

“…Stroke patients with diabetes have worse neurological outcomes than non‐diabetic stroke patients, and treatments beneficial for non‐diabetic stroke patients…”
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Engineering Neurovascular Unit and Blood–Brain Barrier for Ischemic Stroke Modeling by Liu, Ze, Tang, Yaohui, Zhang, Zhijun, Liu, Qianqian, Wang, Mian, Li, Wanlu, Yang, Guo‐Yuan

“…Ischemic stroke is a primary vascular disease of the central nervous system characterized by high morbidity, mortality, and healthcare costs. As conventional…”
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Mesenchymal Stem Cells Attenuated Blood-Brain Barrier Disruption via Downregulation of Aquaporin-4 Expression in EAE Mice by Liu, Yanqun, Ma, Yuanyuan, Du, Bingying, Wang, Yongting, Yang, Guo-Yuan, Bi, Xiaoying

“…Blood-brain barrier disruption is one of the hallmarks of multiple sclerosis. Mesenchymal stem cells showed great potential for the multiple sclerosis therapy…”
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Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis by Guo, Yuan-Yang, Li, Zhen-Hua, Xia, Tian-Yu, Du, Yi-Ling, Mao, Xu-Ming, Li, Yong-Quan

“…Azoxy bond is an important chemical bond and plays a crucial role in high energy density materials. However, the biosynthetic mechanism of azoxy bond remains…”
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Endothelial progenitor cell transplantation improves long-term stroke outcome in mice by Fan, Yongfeng, Shen, Fanxia, Frenzel, Tim, Zhu, Wei, Ye, Jianqin, Liu, Jianrong, Chen, Yongmei, Su, Hua, Young, William L., Yang, Guo-Yuan

“…Objective Endothelial progenitor cells (EPCs) play an important role in tissue repairing and regeneration in ischemic organs, including the brain. However, the…”
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M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice by Li, Zongwei, Song, Yaying, He, Tingting, Wen, Ruoxue, Li, Yongfang, Chen, Tingting, Huang, Shuxian, Wang, Yongting, Tang, Yaohui, Shen, FanXia, Tian, Heng-Li, Yang, Guo-Yuan, Zhang, Zhijun

“…Glial scars present a major obstacle for neuronal regeneration after stroke. Thus, approaches to promote their degradation and inhibit their formation are…”
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Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice by Cheng, Zhuo, Wang, Liping, Qu, Meijie, Liang, Huaibin, Li, Wanlu, Li, Yongfang, Deng, Lidong, Zhang, Zhijun, Yang, Guo-Yuan

“…Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that…”
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CXCR4 Antagonist AMD3100 Protects Blood―Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice by JUN HUANG, YANING LI, YAOHUI TANG, GUANGHUI TANG, YANG, Guo-Yuan, YONGTING WANG

“…Inflammatory response plays a critical role in propagating tissue damage after focal cerebral ischemia. CXCL12 is a key chemokine for leukocyte recruitment…”
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Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke by Cai, Hongxia, Ma, Yuanyuan, Jiang, Lu, Mu, Zhihao, Jiang, Zhen, Chen, Xiaoyan, Wang, Yongting, Yang, Guo-Yuan, Zhang, Zhijun

“…Matrix metalloproteinase 9 (MMP-9) plays a beneficial role in the delayed phase of middle cerebral artery occlusion (MCAO). However, the mechanism is obscure…”
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A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation by Yang, Yong, Ren, Jie, Sun, Yuhao, Xue, Yuan, Zhang, Zhijian, Gong, Aihua, Wang, Baofeng, Zhong, Zhihong, Cui, Zhenwen, Xi, Zhiyu, Yang, Guo-yuan, Sun, Qingfang, Bian, Liuguan

“…Reactive astrogliosis is a common response to insults to the central nervous system, but the mechanism remains unknown. In this study, we found the temporal…”
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Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion by Liu, Yanqun, Tang, Guanghui, Li, Yaning, Wang, Yang, Chen, Xiaoyan, Gu, Xiang, Zhang, Zhijun, Wang, Yongting, Yang, Guo-Yuan

“…Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of metformin…”
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